Blocks, Stars and Combs: Complex Macromolecular Architecture Polymers via Click Chemistry

RAFT-synthesized copolymers and conjugates designed for therapeutic delivery of siRNA

“…45,59,72,73 Though beyond the scope of this review, the reader is referred to reports in this thematic issue as well as to recent reviews of post-polymerization modification methods including orthogonal ''click'' chemistries which have been or can potentially be utilized in delivery. [74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90]…”

Cyclodextrin-poly(ε-caprolactone) based nanoparticles able to complex phenolphthalein and adamantyl carboxylate

“…To obtain an amphiphilic behavior requires the presence of a hydrophilic compound, which also has to comply with the biocompatibility, biodegradability and nontoxicity requirements. Copper catalyzed click chemistry became a very important tool for the synthesis of new polymeric structures over the past years [ 9 ] and represents an attractive method for bonding a polyester chain with a hydrophilic compound [ 10 ].…”

Has Click Chemistry Lead to a Paradigm Shift in Polymer Material Design?

“…For in-depth reviews that present summaries of click chemistries the reader is referred to the excellent compilations of (among others) Evans [3] and Binder [4] as well as the forthcoming book on the use of click chemistry in biotechnology and materials science. [5] In addition, a set of criteria has to be established against which specific examples will be evaluated. Naturally, these criteria should reflect the initial definition provided by Sharpless on what constitutes a click reaction, [1] yet also entail the general philosophical approach behind the click concept.…”