Interventions for the management of taste disturbances

Nagraj, Sumanth Kumbargere; Shetty, Neeta; Kandula, Srinivas; George, P Renjith; Shrestha, Ashish; Levenson, David; Ferraiolo, Debra M

doi:10.1002/14651858.cd010470.pub2

Cited by 15 publications

(3 citation statements)

References 65 publications

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“…Failure to provide appropriate supportive care during treatment has been shown to impact patient adherence to the treatment plan and thus jeopardise the achievement of optimal outcomes (Cardoso et al, 2013). Early identification of unmet needs may thus limit the problems patients face (Nagraj et al, 2014; Ninot et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of radiotherapy, chemotherapy and access to supportive care in cancer in Brazil, China, France, Russia and the USA

Buiret

Delvigne

Dantec

et al. 2022

European J Cancer Care

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Objectives: The objective of this study is to assess the prevalence of treatment with radiotherapy and/or chemotherapy in the general adult population of five countries (Brazil, China, France, Russia and the USA) and to evaluate the use of different Supportive Care in Cancer (SCC) services.Methods: A total of 11,100 individuals representing the general population over 18 years of age were recruited from the five countries via a rigorous quota sampling method.Results: There are between 4.1% and 8.78% of respondents reported having undergone medical cancer treatment. Among these subpopulations, the use of at least one SCC was reported by 63% to 86% of respondents. The most commonly used SCC was psychological counselling in France, dietary counselling in Brazil and China, participating in a focus group in the USA and using alternative medicine in Russia.Alternative medicines were chosen by 50% to 61% of patients in every country. Conclusion:This study provides information on the prevalence of patients treated by chemotherapy and/or radiotherapy in representative populations from five countries. Among them, SCC was widely used. However, these uses varied both in proportion and choice, given the cultural differences in patients' and families' health beliefs and values, differences among organisations, in available resources and in ethics and policies among countries.

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Section: Introductionmentioning

confidence: 99%

Prevalence of radiotherapy, chemotherapy and access to supportive care in cancer in Brazil, China, France, Russia and the USA

Buiret

Delvigne

Dantec

et al. 2022

European J Cancer Care

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“…The sense of taste is fundamental to sustain health and quality of life and is crucial for an individual’s well-being and psychological health, yet it is generally taken for granted. Taste disorders can range from distortion of taste to reduced ability to taste to complete absence of taste 2. Taste impairment is common in cancer patients which may be due to the disease itself or because of the cancer treatments 3.…”

Section: Introductionmentioning

confidence: 99%

“…Zinc is an integral element in both the maintenance and repair of taste buds. Zinc is an important cofactor for alkaline phosphatase and is needed for its synthesis; the most important and abundant enzyme in taste bud membranes 2. Zinc influences the synthesis of gustin (carbonic anhydrase VI) required for the growth, development, maintenance and production of taste buds and regulation of taste function 9.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of zinc sulfate on concurrent chemoradiotherapy induced taste alterations in oral cancer patients: A double blind randomized controlled trial

2019

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Objectives: To observe the efficacy of zinc sulfate on taste alterations in oral cancer patients receiving concurrent chemotherapy with radiotherapy. Methods: Seventy patients were randomly assigned to both intervention and control group at Oncology Section of Atomic Energy Medical Centre Karachi from September 2017 to March 2018. One group received zinc sulfate capsules (50 mg TDS daily after meals) and the other group received placebo (thrice after meals). Patients were advised to start taking capsules on the first day of their chemoradiation. Both the groups continued the capsules a month after their CCRT ended. Results: Sweet taste was most effected by cancer and its treatment followed by bitter and salty taste. Sour taste was least effected. When both the groups were compared for four tastes for detection threshold, the differences in observation at 3 stages of median IQR were not significant. For recognition threshold between zinc sulfate and placebo, no significant difference was observed in median IQR for salty taste and bitter taste. However, sweet taste (baseline p-value 0.245, end p-value 0.010, follow-up p-value 0.038) was statistically significant at end of CCRT and follow-up stage and sour taste (baseline p-value 0.24, end p-value 0.006, follow-up p-value 0.898) at end of CCRT only. Conclusion: Zinc sulfate was not found to be beneficial in preventing chemoradiation induced taste alterations. Taste and smell alterations are common in patients with cancer and do not receive sufficient support to manage taste alterations. This area requires more research to develop a comprehensive understanding of the nature and its management. Abbreviations: CCRT = Concurrent chemoradiotherapy. DT = Detection threshold. RT = Recognition threshold. AEMC = Atomic Energy Medical Centre. doi: https://doi.org/10.12669/pjms.35.3.503 How to cite this:Khan AH, Safdar J, Siddiqui SU. Efficacy of zinc sulfate on concurrent chemoradiotherapy induced taste alterations in oral cancer patients: A double blind randomized controlled trial. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.503 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Interventions for managing taste disturbances

Nagraj

George

Shetty

et al. 2017

Cochrane Database of Systematic Reviews

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Interventions for the management of taste disturbances

Abstract: To assess the effects of interventions for the management of patients with taste disturbances.

Cited by 15 publications

References 65 publications

Prevalence of radiotherapy, chemotherapy and access to supportive care in cancer in Brazil, China, France, Russia and the USA

Prevalence of radiotherapy, chemotherapy and access to supportive care in cancer in Brazil, China, France, Russia and the USA

Efficacy of zinc sulfate on concurrent chemoradiotherapy induced taste alterations in oral cancer patients: A double blind randomized controlled trial

Interventions for managing taste disturbances

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