Habitus of Patients With Active Sickle Cell Anemia of Long Duration

Winsor, Travis; Burch, George E.

doi:10.1001/archinte.1945.00210310055007

Cited by 17 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of these changes were found to be less pronounced and inconsistent in children, and some investigators considered this appearance in SCD to be an exaggeration of the normal characteristics of Africans. 21 Affected children were reported to have poor nutrition and their weight was consistently below the median reference values.…”

Section: Growth Studiesmentioning

confidence: 99%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

View full text Add to dashboard Cite

Background: Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarises evidence of nutritional status in children with SCD in relation to anthropometric status, disease severity, body composition, energy metabolism, micronutrient deficiency and endocrine dysfunction. Methods: A literature search was conducted on the Medline/PUBMED, SCOPUS, SciELO and LILACS databases to July 2007 using the keywords sickle cell combined with nutrition, anthropometry, growth, height and weight, body mass index, and specific named micronutrients. Results: Forty-six studies (26 cross-sectional and 20 longitudinal) were included in the final anthropometric analysis. Fourteen of the longitudinal studies were conducted in North America, the Caribbean or Europe, representing 78.8% (2086/2645) of patients. Most studies were observational with wide variations in sample size and selection of reference growth data, which limited comparability. There was a paucity of studies from Africa and the Arabian Peninsula, highlighting a large knowledge gap for low-resource settings. There was a consistent pattern of growth failure among affected children from all geographic areas, with good evidence linking growth failure to endocrine dysfunction, metabolic derangement and specific nutrient deficiencies. Conclusions: The monitoring of growth and nutritional status in children with SCD is an essential requirement for comprehensive care, facilitating early diagnosis of growth failure and nutritional intervention. Randomised controlled trials are necessary to assess the potential benefits of nutritional interventions in relation to growth, nutritional status and the pathophysiology of the disease.

show abstract

Section: Growth Studiesmentioning

confidence: 99%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

View full text Add to dashboard Cite

show abstract

“…2 Menarche was delayed by a mean interval of 1.7 years in Washington DC,3and by 2.3–3.0 years in different studies in Jamaica 4-67genotype contributing little after these factors were taken into account.…”

mentioning

confidence: 94%

Sickle cell disease and age at menarche in Jamaican girls: observations from a cohort study

Serjeant

Singhal

Hambleton

2001

Archives of Disease in Childhood

View full text Add to dashboard Cite

Aims-(1) To investigate the distribution of age at menarche in a representative sample of 99 patients with homozygous sickle cell (SS) disease, 69 with sickle cell haemoglobin C (SC) disease, and 100 controls with a normal haemoglobin (AA) genotype followed in a cohort study from birth. (2) To explore the determinants of the age at menarche. Methods-Children ascertained in a newborn screening programme were followed prospectively from birth to age 18-26.5 years with regular assessments of height, weight, pubertal stage, and haematological indices at the Sickle Cell Clinic of the University Hospital of the West Indies. Results-All subjects have now reached menarche and the mean age in normal controls (13.0 years) was significantly earlier than in SC disease (13.5 years) or SS disease (15.4 years). Greater weight and earlier age at menarche was the only association significant across all genotypes although additional contributions occurred from fetal haemoglobin and red cell count in SS disease. Alpha thalassaemia, which ameliorates many of the eVects of SS disease, had no discernible eVect on menarche.

show abstract

“…Growth Menarche was delayed to 18 years in Washburn's (1911) case and Mason (1922) reported a slender build, absence of axillary and scant pubic hair in a 21‐year‐old man. Further papers commented on the tendency of sickle cell patients to be tall and slim (Diggs & Ching, 1934; Sharp & Vonder Heide, 1944) and early anthropometric studies recorded the long thin limbs, narrow pectoral and pelvic girdles, hoop shaped chest and low body weight (Winsor & Burch, 1944, 1945). The abnormal growth and some of its determinants have been documented from both the Cooperative Study in the USA (Platt et al , 1984) and the Jamaican Cohort Study (Stevens et al , 1986).…”

mentioning

confidence: 99%