10 Years of Click Chemistry: Synthesis and Applications of Ferrocene‐Derived Triazoles

Abstract

Click chemistry has played a significant role as a rapid and versatile strategy for conjugating two molecular fragments under very mild reaction conditions. Introduction of ferrocene-derived triazole systems using click chemistry has attracted enormous interest in various fields due to its potential applications in electrochemical techniques for detection and sensing. The present discussion focuses on the synthesis of ferrocene-triazole and the importance of using a CuAAC reaction for such conjugation. Applications of ferrocene-based click reactions in conjugate chemistry, asymmetric catalysis, medicinal chemistry, host-guest interactions, and materials chemistry have been highlighted.

Electrochemistry and liquid crystal properties of mono-substituted 1,2,3-triazolylferrocene derivatives

“…Recently, we have reported a series of 1,2,3-(NH)-triazolyl ferrocenomesogens with good redox activity [21]. To the best of our knowledge, this is the first example of mesogen-based 1,2,3-triazolylferrocene derivatives though ferrocene-triazole conjugates have been applied in various fields [22,23]. Further efforts to obtain new mesogenic materials gave rise to a series of mono-substituted ferrocene-triazole compounds which are described in the present article.…”

Pyrrole, imidazole, and triazole derivatives as ion-pair recognition receptors

“…In fact, the wettability can be modulated reversibly in the presence/absence of 1-butyl-3-methylimidazolium chloride. 28 Taking into account that ferrocene-triazole derivatives are one of the systems that have potential applications in the field of electrochemical detection and sensing and host-guest chemistry 29 we have recently reported a number of ion-pair recognition receptors bearing a central unsymmetrically 1,1 0 -disubstituted ferrocene. These receptors are available from 1,1 0 -bis(diazido)ferrocene by sequential functionalization through click-type chemistry and the Staudinger reaction.…”

Dielectric breakdown strength of epoxy bimodal-polymer-brush-grafted core functionalized silica nanocomposites

“…Ferrocene is known to be very reactive in "click" reactions [25] and it is possible that in a one-pot synthesis it will react much faster than longer PGMA and occupy most of the available positions. The presence of the electroactive molecule was verified by UV-vis spectroscopy.…”