10 years followup in children affected by various eye diseases: sensibility and specificity of VA, fundus and 30 Hz and mixed response electroretinogram done during anaesthesia as predictors of visual outcome

Abstract

Purpose This study aimed to define the relationship between 30 herz and mixed maximal response electroretinogram, recorded under anaesthesia, and the visual outcome in subjects affected by various retinal and/or optic disk affections. Methods We present a review of 87 among 260 children examined under anaesthesia. All subjects(mean age 3,12)underwent ERG without adaptation, in a mid luminance, at 30 hertz and mixed maximal response. Results were matched with fundus findings and the visual acuities. Multiple statistical analysis comprehending student’s t test for independent samples was used for comparisons between groups. A P value of less than 0.05 was assumed to indicate statistical significance. Results Diagnosis linking fundus findings and ERG were: 7 Leber dystrophy, 12 ROP, 20 retinal dystrophy, 6 ny, 5 CVI, 2 Joubert syndrome, 1 Retinoblastoma, 5 ON coloboma, 1 Morning glory syndrome, 12 pale papilla, 2 congenital cataract associated with retinal anomalies, 14 not defined. Mean VA was 1,94 in right eye, 2,04 in the left. Significant correlations and “p” values were found between 30 hz amplitude, a and b amplitudes, b latency and visual acuities. ROC curves were statistically significant in latency and ampitudes in a and b waves. Conclusion Our work indicate a correlation between fundus findings, ERG and visual outcome. When we are unable to perform a correct diagnosis by visit and instrumental methods in awake conditions, a brief anaesthesia allow to obtain results otherwise arduous.