10-Year outcomes after Roux-en-Y gastric bypass

Mehaffey, J. Hunter; LaPar, Damien J.; Clement, Kathleen C.; Seaman, Sierra J.; Turrentine, Florence E.; Miller, Michael S.; Hallowell, Peter T.; Schirmer, Bruce D.

doi:10.1016/j.jamcollsurg.2015.08.012

Cited by 16 publications

(15 citation statements)

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“…Typically, the excellent initial weight loss nadir is followed by 5.0-20.0% EW regain; however, RYGBP weight loss ≥ 50.0% is typically maintained over the long term. In studies 10-year follow-up, T2DM resolves in 50.0-80.0% of RYGBP patients, depending on the severity and duration of disease [96,97], an undeniable attribute of bariatric surgery that caused the American Diabetes Association (ADA) to recommend it in their treatment algorithm [93]. Importantly significantly by 40.0%, particularly deaths from heart disease, T2DM, and cancer [98].…”

Section: Indications/contraindications Weight Loss Diabetesmentioning

confidence: 99%

Standardization of Bariatric Metabolic Procedures: World Consensus Meeting Statement

Bhandari

Fobi

Buchwald³

2019

OBES SURG

108

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Background Standardization of the key measurements of a procedure's finished anatomic configuration strengthens surgical practice, research, and patient outcomes. A consensus meeting was organized to define standard versions of 25 bariatric metabolic procedures. Methods A panel of experts in bariatric metabolic surgery from multiple continents was invited to present technique descriptions and outcomes for 4 classic, or conventional, and 21 variant and emerging procedures. Expert panel and audience discussion was followed by electronic voting on proposed standard dimensions and volumes for each procedure's key anatomic alterations. Consensus was defined as ≥ 70% agreement. Results The Bariatric Metabolic Surgery Standardization World Consensus Meeting (BMSS-WOCOM) was convened March 22-24, 2018, in New Delhi, India. Discussion confirmed heterogeneity in procedure measurements in the literature. A set of anatomic measurements to serve as the standard version of each procedure was proposed. After two voting rounds, 22/25 (88.0%) configurations posed for consideration as procedure standards achieved voting consensus by the expert panel, 1 did not attain consensus, and 2 were not voted on. All configurations were voted on by ≥ 50% of 50 expert panelists. The Consensus Statement was developed from scientific evidence collated from presenters' slides and a separate literature review, meeting video, and transcripts. Review and input was provided by consensus panel members. Conclusions Standard versions of the finished anatomic configurations of 22 surgical procedures were established by expert consensus. The BMSS process was undertaken as a first step in developing evidence-based standard bariatric metabolic surgical procedures with the aim of improving consistency in surgery, data collection, comparison of procedures, and outcome reporting.

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Section: Indications/contraindications Weight Loss Diabetesmentioning

confidence: 99%

Standardization of Bariatric Metabolic Procedures: World Consensus Meeting Statement

Bhandari

Fobi

Buchwald³

2019

OBES SURG

108

View full text Add to dashboard Cite

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“…The procedure was originally designed to achieve and sustain weight loss, and it was subsequently noted to induce improvements in glucose regulation. In both short‐ and long‐term trials, clinical studies have shown that bariatric surgery results in substantial weight loss and either improvement or remission of type 2 diabetes mellitus. As clinical data were accumulated, some versions of these procedures were ultimately abandoned because of complications related to the surgery.…”

Section: Introductionmentioning

confidence: 99%

Role of gut microbiota, bile acids and their cross‐talk in the effects of bariatric surgery on obesity and type 2 diabetes

Liu

Zhang

et al. 2017

J of Diabetes Invest

108

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Type 2 diabetes mellitus is becoming increasingly prevalent worldwide, and has become one of the greatest threats to global health. Bariatric surgery was initially designed to achieve weight loss, and subsequently was noted to induce improvements or remission of type 2 diabetes. Currently, these bariatric operations, such as Roux‐en‐Y gastric bypass and sleeve gastrectomy, are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the specific mechanism mediating the beneficial effects of metabolic surgery has remained largely unknown. Those mechanical explanations, such as restriction and malabsorption, are challenged by accumulating evidence from human and animal models of these procedures, which points to the weight‐independent factors, such as hormones, bile acids, gut microbiota, nervous system and other potential underlying mechanisms. A growing body of evidence suggests that gut microbiota are associated with the development of several metabolic disorders, and bile acids and FXR signaling are important for the metabolic benefits of bariatric surgery. Given the close relationship between bacteria and bile acids, it is reasonable to propose that microbiota–bile acid interactions play a role in the mechanisms underlying the effects of metabolic surgery.

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“…Obesity continues to be of epidemic proportions, affecting as many as 12% of adults in the world and is a major cause of erosions in quality of life (1,2) . Bariatric surgery has been well established as an effective and durable intervention for severe obesity and co-morbid conditions (3) . While there are prospective long-term studies that suggest health-related quality of life (HR-QoL) improves after bariatric surgery (4) it has been noted that these improvements have generally been less well established compared to weight loss and comorbidity improvement/resolution due to the variations in reporting of QoL (5) .…”

Section: Introductionmentioning

confidence: 99%

A behavioral rating system predicts weight loss and quality of life after bariatric surgery

Hilgendorf

Butler

Timsina

et al. 2018

Surgery for Obesity and Related Diseases

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10-Year outcomes after Roux-en-Y gastric bypass

Cited by 16 publications

References 0 publications

Standardization of Bariatric Metabolic Procedures: World Consensus Meeting Statement

Standardization of Bariatric Metabolic Procedures: World Consensus Meeting Statement

Role of gut microbiota, bile acids and their cross‐talk in the effects of bariatric surgery on obesity and type 2 diabetes

A behavioral rating system predicts weight loss and quality of life after bariatric surgery

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