10 year course of IQ in first-episode psychosis: Relationship between duration of psychosis and long-term intellectual trajectories

Barder, Helene Eidsmo; Sundet, Kjetil; Rund, Bjørn Rishovd; Evensen, Julie; Haahr, Ulrik; Hegelstad, Wenche ten Velden; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes; Larsen, Tor Ketil; Melle, Ingrid; Opjordsmoen, Stein; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas H.; Friis, Svein

doi:10.1016/j.psychres.2014.11.054

Cited by 20 publications

(18 citation statements)

References 43 publications

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“…This "neurotoxicity hypothesis" was introduced by Wyatt (1991), who suggested that neuroleptics may interrupt the toxic process of psychosis and ensure a better long-term course of schizophrenia. In adult samples, some longitudinal studies find a relationship between shorter DUP and better overall cognitive function (Cuesta et al, 2012;Dominguez et al, 2013;Yamazawa et al, 2008), however, a majority of studies report no association between the two (Barder et al, 2015;Goldberg et al, 2009;Melle et al, 2008;Rund et al, 2007). In EOS, research on the interaction between DUP and cognition is rare.…”

Section: The Relationship Between Symptoms and Cognitionmentioning

confidence: 99%

Gestational length affects neurocognition in early-onset schizophrenia

Teigset

Mohn

Rund

2016

Psychiatry Research

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Obstetric complications (OC) have been linked to an increased risk for schizophrenia in offspring, especially in early-onset schizophrenia (EOS). Extensive cognitive deficits occur in EOS, although no study has yet to investigate the relationship between OC and cognition in EOS. This study aims to examine the frequency of OC in EOS compared to controls, and also investigates the relationship between OC and neurocognitive dysfunction in the two groups. Nineteen EOS patients and 53 healthy controls were tested with the MATRICS Consensus Cognitive Battery (MCCB), and the cognitive measures were combined with OC data from the Norwegian Birth Registry. The results indicated no group differences in OC in EOS and healthy controls, but a shorter gestational length in the EOS group led to significant decreases in the overall neurocognitive composite score, and in processing speed. This suggests that the poorer neuropsychological performances commonly found in EOS may be partly attributable to the length of gestation. The worsened neurocognitive functioning did not appear among controls, so gestational length had a different impact on the two groups. Our findings indicated that a shorter gestational length did not increase the risk for developing EOS, but did significantly affect the cognitive difficulties in this group.

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Section: The Relationship Between Symptoms and Cognitionmentioning

confidence: 99%

Gestational length affects neurocognition in early-onset schizophrenia

Teigset

Mohn

Rund

2016

Psychiatry Research

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“…However, the longitudinal course of cognitive functioning and its predictors in schizophrenia remain unclear ( Bora and Murray, 2014 , Bozikas and Andreou, 2011 , Irani et al, 2010 ). Longitudinally, in one study, 10-years follow-up duration of untreated psychosis (DUP) and change of IQ did not relate, but a subgroup with long duration of active psychosis after the start of treatment demonstrated a significant cognitive decline ( Barder et al, 2014 ). Low education, instead, has been associated with decline in selective attention over 4.5 years follow-up ( Ekerholm et al, 2012 ) and decline in other cognitive scores (e. g., immediate memory, language, delayed memory) ( Han et al, 2012 ); these results, combined with prior studies suggesting that scholastic performance may predict schizophrenia risk ( Jones et al, 1994 , MacCabe et al, 2008 ) and illness severity ( Lauronen et al, 2007 , Mäkinen et al, 2010 ), encouraged us to further investigate whether premorbid scholastic performance is associated with subsequent course of cognition in schizophrenia within the population based setting of the Northern Finland Birth Cohort 1966.…”

Section: Introductionmentioning

confidence: 97%

Poor premorbid school performance, but not severity of illness, predicts cognitive decline in schizophrenia in midlife

Rannikko

Murray

Juola

et al. 2015

Schizophrenia Research: Cognition

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Neurocognitive dysfunction is common in schizophrenia but its course and determinants remain uncertain. Our aim was to analyse if premorbid school performance and the severity of illness and functioning predict change in cognition in schizophrenia in a general population sample.The sample included cases with schizophrenia spectrum disorder from the Northern Finland Birth Cohort 1966. Data on school marks at the age of 16 years, educational level at the age of 34 years, severity of symptoms and occupational functioning around first episode and after years of illness were gained from national registers, hospital notes and interviews. Change of verbal and visual learning and memory and executive functioning were examined between ages 34 and 43 years. The number of cases varied in analyses from 29 to 41, depending on missing data in particular cognitive tests.Lower school marks at age 16 years and lower education at age 34 years predicted more decline of cognition. Measures of severity of illness or functioning were not associated statistically significantly with change of cognition.Premorbid school performance, but not later course of schizophrenia, related to change of cognition in midlife. Poor premorbid scholastic performance and post-onset cognitive decline may represent related processes as part of an endophenotype of schizophrenia.

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“…Current literature provides no data regarding average DUP length in Serbia, Western‐Balkan upper‐middle income country with population over 7 000 000; thus, our goals were to evaluate the DUP in the Serbian sample of patients with schizophrenia‐spectrum disorders and to further analyse the effects of different factors potentially influencing DUP length: (i) factors that have been previously suggested to influence treatment delay (sex, education, IQ, premorbid adjustment and age at the illness onset); (ii) factors that have been understudied to date in relation to DUP length (personality traits); and (iii) factors that have not been studied at all to date in relation to DUP (paternal age). The relation of DUP to paternal age was not based on a priori hypothesis.…”

Section: Introductionmentioning

confidence: 99%