10-MV X-ray dose calculation in water for MLC and wedge fields using a convolution method with X-ray spectra reconstructed as a function of off-axis distance

Abstract

Purposes: This paper highlights a 10-MV X-ray convolution dose calculation method in water using primary and scatter dose kernels formed for energy bins of X-ray spectra reconstructed as a function of the off-axis distance for a linear accelerator equipped with pairs of upper and lower jaws, a multileaf collimator (MLC) and a wedge filter. Methods: The reconstructed X-ray spectra set was composed of 11 energy bins. To estimate the in-air beam intensities at points on the isocenter plane for an MLC field, we employed an MLC leaf-field output subtraction method, using an extended radiation source on each of the X-ray target and the flattening filter as well as simplified twodimensional plates to simulate the three-dimensional jaws and MLC structures. A special correction factor was introduced for nonuniform incident beam intensities, particularly produced at MLC fields. The in-phantom dose calculation was performed by treating the phantom, the wedge filter, the wedge holder and the MLC as parts of a unified irradiated body, where we proposed to use a special factor for the density scaling theorem within the unified irradiated body. Conclusions: The phantom dose was generally separated into nine dosecomponents: the primary and scatter dose-components produced in the phantom; the primary and scatter dose-components emanating from the wedge, the wedge holder and the MLC; and the electron contamination dose-component. From the calculated and measured percentage depth dose (PDD) and off-center ratio (OCR) datasets, we may conclude that the convolution method can achieve accurate dose calculations even under MLC and/or wedge filtration.Keywords: convolution method; X-ray spectra; dose kernels; wedge; multileaf collimation; MLC leaf-field output subtraction Citation: Iwasaki A, Kimura S, Sutoh K, Kamimura K, Sasamori M, Seino M, Komai F, Takagi M, Terashima S, Hosokawa Y, Saitoh H, Miyazawa M. 10-MV X-ray dose calculation in water for MLC and wedge fields using a convolution method with X-ray spectra reconstructed as a function of off-axis distance. J

The anti-leukemia activity and mechanisms of shikonin: a mini review

“…ERS and activation of unfold protein response are the major factors contribute to chemoresistance in cancer cells (Xia et al, 2021). Induction of ERS is an important mechanism for SHKinduced apoptosis in prostate cancer cells, 5-fluorouracil-resistant colorectal cancer cells, and colon cancer cells (Gara et al, 2015;Han et al, 2019;Piao et al, 2022). In adult T cell leukemia/lymphoma cells, activation of ERS was related to SHK-induced cell apoptosis (Boonnate et al, 2023).…”