10 Lageanomalien des Herzens und Anomalien des Situs

Kleideiter, Ulrich; Pozza, Robert Dalla; Haas, Nikolaus A.

doi:10.1055/b-0039-170952

Cited by 1 publication

(2 citation statements)

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“…Aortic VTI z‐scores and LV EF (Simpson) showed no significant correlation with TAPSE z‐scores after stepwise regression, which could mean that TAPSE values are not dependent on the left ventricular function. But as there were only five patients in our study who showed abnormal LV EF ≤55%, this result may not represent the entire population of pediatric heart transplant recipients 31 . There are studies showing the correlation between left ventricular EF and TAPSE in adults with severe systolic left ventricular dysfunction, end‐stage renal disease, severe aortic stenosis or heart failure, but there is as of yet no data on the interdependence of TAPSE and left ventricular parameters in children after HTx 32–35 …”

Section: Discussionmentioning

confidence: 77%

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Tricuspid Annular Plane Systolic Excursion (TAPSE) correlates with mean pulmonary artery pressure especially 10 years after pediatric heart transplantation

Michalski

Haas

Pozza

et al. 2022

Clinical Transplantation

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Tricuspid annular plane systolic excursion (TAPSE) is important in the noninvasive echocardiographic assessment of right heart function. This retrospective observational study shows correlations of TAPSE with invasive right heart catheterization parameters after pediatric heart transplantation (HTx). The study included patients after pediatric HTx with cardiac catheterizations in 2018/2019 and measurement of TAPSE (n = 52 patients with 57 examinations; 50.9% adults, 52.6% female, median age: 18.54 years). TAPSE was compared with normal values. Stepwise, linear and multiple regression were used to show influencing variables on TAPSE. Mean TAPSE z-score was −3.48 (SD: 2.25) and 68.4% of HTx-recipients showed abnormally reduced TAPSE (z-score ←2) compared to normal values. Multiple regression (p-value <0.001; corrected R 2 = 0.338) showed significant correlations of time since HTx (p-value <0.001) and mPAP (p-value: 0.008) with TAPSE z-scores. Divided into subgroups (time since HTx <10 and ≥10 years), TAPSE and mPAP correlated only ≥10 years after HTx (p-value = 0.002). This study provides data of TAPSE even ≥10 years after pediatric HTx. Most patients showed a decreased TAPSE early after HTx, which improved over time. TAPSE z-scores correlated significantly with time since HTx and mPAP, especially ≥10 years post-HTx. Therefore, TAPSE must be used carefully in the early follow-up.

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Section: Discussionmentioning

confidence: 77%

“…But as there were only five patients in our study who showed abnormal LV EF ≤55%, this result may not represent the entire population of pediatric heart transplant recipients. 31 There are studies showing the correlation between left ventricular EF and TAPSE in adults with…”

Section: Left Ventricular Functionmentioning

confidence: 99%