10 km running race induces an elevation in the plasma myokine level of nonprofessional runners

Marcucci-Barbosa, Lucas Soares; Martins-Júnior, Francisco de Assis Dias; Lobo, Lázaro Fernandes; Morais, Mariana; Moreira, Janaína Matos; Vieira, Érica Leandro Marciano; Nunes-Silva, Albená

doi:10.1007/s11332-019-00608-3

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…In our study, acute exercise to fatigue was associated with an increase in circulating concentrations of several cytokines, including IL-6, TNF- α , sTNFR1, IL-10, CXCI10/IP-10, BDNF, leptin, adiponectin, and resistin. This elevation is similar to that found by other studies [ 28 – 30 , 61 – 63 ] and is consistent with the idea that acute exercise may function as an acute inflammatory stimulus [ 64 – 66 ]. Elevated cytokines included proinflammatory molecules (IL-6, TNF- α ), molecules with anti-inflammatory activity (IL-10, sTNFR1), adipokines (leptin, adiponectin, resistin), and neurotrophic factors (BDNF).…”

Section: Discussionsupporting

confidence: 92%

Aerobic Training Modulates the Increase in Plasma Concentrations of Cytokines in response to a Session of Exercise

Fonseca

Mendes

Ramos

et al. 2021

Journal of Environmental and Public Health

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Acute physical exercise can modulate immune function. For example, acute exercise is known to increase the circulating concentration of cytokines. Exercise is also known to modulate immune function chronically. It is not known whether exercise training can result in training of the immune system. Here, we investigated the effects of six weeks of aerobic training on cytokine responses induced by acute exercise until fatigue. Twelve healthy men performed a fatiguing exercise at the anaerobic threshold (AT) intensity. After the training period, the participants performed another bout of acute exercise at the same duration and intensity of the pretraining situation. The analysis was made at the beginning, end, and at 10, 30, and 60 minutes during the recovery period. Training at AT induced a gain of 11.2% of exercise capacity. Before training, a single bout of acute exercise induced a significant increase in plasma levels of cytokines, including IL-6, TNF-α, sTNFR1, IL-10, CXCL10, BDNF, leptin, resistin, and adiponectin. After six weeks of aerobic training, levels of IL-6, sTNFR1, BDNF, and leptin increased to a lesser extent after an acute bout exercise at the same absolute intensity as the pretraining period. Responses to the same relative exercise intensity were similar to those observed before exercise. These results show that aerobic training is associated with training of acute immune responses to acute exercise until fatigue.

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Section: Discussionsupporting

confidence: 92%

Aerobic Training Modulates the Increase in Plasma Concentrations of Cytokines in response to a Session of Exercise

Fonseca

Mendes

Ramos

et al. 2021

Journal of Environmental and Public Health

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“…For acute exercise, a total of 411 participants with mean ages and BMIs ranging from ~19 to 84 years and 20 to 35 kg/m 2 , respectively, were included. Of the 15 included studies, four studies consisted of females ( 31 , 51 , 56 , 57 ), six studies consisted of males ( 36 , 46 , 48 , 50 , 52 , 54 ), and the remaining studies consisted of both males and females ( 47 , 49 , 55 ). Two studies did not clearly report the biological sex of participants ( 35 , 53 ).…”

Section: Resultsmentioning

confidence: 99%

Interleukin-15 responses to acute and chronic exercise in adults: a systematic review and meta-analysis

Khalafi,

Maleki,

Symonds

et al. 2024

Front. Immunol.

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PurposeInterlukin-15 (IL-15) is an inflammatory cytokine that plays a vital role in immunology and obesity-associated metabolic syndrome. We performed this systematic review and meta-analysis to investigate whether exercise promotes circulating IL-15 concentrations in adults.MethodsWe searched PubMed, Web of Science, and Scopus from inception to May, 2023 and identified original studies that investigated the effectiveness of acute and/or chronic exercise on serum/plasma IL-15 levels in adults. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated using random effect models. Subgroup analyses were performed based on type of exercise, and training status, health status and body mass indexes (BMI) of participants.ResultsFifteen studies involving 411 participants and 12 studies involving 899 participants were included in the acute and chronic exercise analyses, respectively. Our findings showed that acute exercise increased circulating IL-15 concentrations immediately after exercise compared with baseline [SMD=0.90 (95% CI: 0.47 to 1.32), p=0.001], regardless of exercise type and participants’ training status. Similarly, acute exercise was also associated with increased IL-15 concentrations even one-hour after exercise [SMD=0.50 (95% CI: 0.00 to 0.99), p=0.04]. Nevertheless, chronic exercise did not have a significant effect on IL-15 concentrations [SMD=0.40 (95% CI: -0.08 to 0.88), p=0.10].ConclusionOur results confirm that acute exercise is effective in increasing the IL-15 concentrations immediately and one-hour after exercise intervention, and thereby playing a potential role in improving metabolism in adults.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=445634, identifier CRD42023445634.

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“…BDNF is a member of the neurotrophin family, mainly expressed in the brain and involved in neuronal cell development (Schnyder and Handschin, 2015). However, it is also expressed in SKM, in response to physical exercise, where it is involved in metabolism regulation (Roh et al, 2017;Lucas Soares Marcucci-Barbosa et al, 2019). In vitro experiments have demonstrated the increase of BDNF in SKM cells where it enhances fatty acid oxidation via AMPK after electric stimulation (Matthews et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that both OSM expression in SKM tissue and serum levels increase immediately after one hour of swimming exercise in mice (Hojman et al, 2011). However, a 10 km run has not affected the plasma level in healthy men immediately after the competition (Lucas Soares Marcucci-Barbosa et al, 2019). Osteonectin is a glycoprotein identified as a structural component of bone, although it was also observed expressed in other tissues (Lane and Sage, 1994).…”

Section: Discussionmentioning

confidence: 99%

Acute changes in free and extracellular vesicle-associated circulating miRNAs and myokine profile in professional sky-runners during the Gran Sasso d’Italia vertical run

Faraldi

Sansoni²,

Perego³

et al. 2022

Front. Mol. Biosci.

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The modification of gene expression profile, a first step in adaptation to exercise, leads to changes in the level of molecules associated with skeletal muscle activity and energy metabolism—such as myokines—as well as those involved in their transcriptional regulation, like microRNA. This study aimed to investigate the influence of strenuous exercise on circulating microRNAs and their possible association with myokine response. Pre-competition and post-competition plasma samples were collected from 14 male athletes participating in a vertical run (+1,000 m gain, 3,600 m length). Circulating total (t-miRNA) and extracellular vesicle-associated (EV-miRNA) miRNAs were extracted from the pooled plasma. Nanoparticle tracking analysis was performed to investigate pre- and post-competition EV concentration and size distribution. A panel of 179 miRNAs was assayed by qPCR and analyzed by Exiqon GenEx v6 normalized on the global mean. t-miRNA and EV-miRNAs whose level was ≥5-fold up- or down-regulated were validated for each single subject. Target prediction on MirWalk v3.0, Gene-Ontology, and pathway enrichment analysis on Panther v17.0 were performed to define the potential biological role of the identified miRNAs. A panel of 14 myokines was assayed in each sample by a multiplex immunoassay. In whole plasma, five miRNAs were upregulated and two were downregulated; in the EV fraction, five miRNAs were upregulated and three were downregulated. Nanoparticle tracking analysis revealed a similar EV size distribution in pre- and post-competition samples and a decreased concentration in post-competition samples related to pre-competition samples. Gene-Ontology and pathway enrichment analysis revealed that the identified t-miRNAs and EV-miRNAs were potentially involved in metabolism regulation in response to exercise. Correlation between fold-change of the post-competition relative to pre-competition plasma level of both t-miRNAs and EV-miRNAs and myokines further confirmed these results. This study provides an example of a systemic response to acute endurance exercise, in which circulating miRNAs play a pivotal role.

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10 km running race induces an elevation in the plasma myokine level of nonprofessional runners

Cited by 5 publications

References 23 publications

Aerobic Training Modulates the Increase in Plasma Concentrations of Cytokines in response to a Session of Exercise

Aerobic Training Modulates the Increase in Plasma Concentrations of Cytokines in response to a Session of Exercise

Interleukin-15 responses to acute and chronic exercise in adults: a systematic review and meta-analysis

Acute changes in free and extracellular vesicle-associated circulating miRNAs and myokine profile in professional sky-runners during the Gran Sasso d’Italia vertical run

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