10-Hz Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex Reduces Heroin Cue Craving in Long-Term Addicts

Shen, Ying; Cao, Xinyu; Tan, Tao; Shan, Chunlei; Wang, Yingjie; Pan, Jibin; He, Hao; Yuan, Ti‐Fei

doi:10.1016/j.biopsych.2016.02.006

Cited by 123 publications

(113 citation statements)

References 13 publications

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“…However, animal tracing [Paus, ] and human smoking craving [Kober et al, ] studies reveal the interactions between the striatum and prefrontal regions are afferent (i.e., the prefrontal region provides input to the striatum), which suggest the feasibility of top‐down modulation of the DLPFC on striatal reward processing in response to smoking craving. Further studies using rTMS or tDCS in smokers might help to infer directionality [Shen et al, ]. Although the OFC has extensive anatomical connections with the striatum and limbic region, we did not observe any OFC derived target regions in PPI analysis.…”

Section: Discussioncontrasting

confidence: 55%

The left dorsolateral prefrontal cortex and caudate pathway: New evidence for cue-induced craving of smokers

Yuan

et al. 2017

Hum. Brain Mapp.

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Although the activation of the prefrontal cortex (PFC) and the striatum had been found in smoking cue induced craving task, whether and how the functional interactions and white matter integrity between these brain regions contribute to craving processing during smoking cue exposure remains unknown. Twenty-five young male smokers and 26 age- and gender-matched nonsmokers participated in the smoking cue-reactivity task. Craving related brain activation was extracted and psychophysiological interactions (PPI) analysis was used to specify the PFC-efferent pathways contributed to smoking cue-induced craving. Diffusion tensor imaging (DTI) and probabilistic tractography was used to explore whether the fiber connectivity strength facilitated functional coupling of the circuit with the smoking cue-induced craving. The PPI analysis revealed the negative functional coupling of the left dorsolateral prefrontal cortex (DLPFC) and the caudate during smoking cue induced craving task, which positively correlated with the craving score. Neither significant activation nor functional connectivity in smoking cue exposure task was detected in nonsmokers. DTI analyses revealed that fiber tract integrity negatively correlated with functional coupling in the DLPFC-caudate pathway and activation of the caudate induced by smoking cue in smokers. Moreover, the relationship between the fiber connectivity integrity of the left DLPFC-caudate and smoking cue induced caudate activation can be fully mediated by functional coupling strength of this circuit in smokers. The present study highlighted the left DLPFC-caudate pathway in smoking cue-induced craving in smokers, which may reflect top-down prefrontal modulation of striatal reward processing in smoking cue induced craving processing. Hum Brain Mapp 38:4644-4656, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussioncontrasting

confidence: 55%

The left dorsolateral prefrontal cortex and caudate pathway: New evidence for cue-induced craving of smokers

Yuan

et al. 2017

Hum. Brain Mapp.

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“…Alternatively, rPAS abnormality may reflect a use-dependent plasticity [29–32], implying that myopathic patients perform greater efforts for various activities of daily living, thus explaining the easy fatigability of such individuals. Furthermore, muscular dystrophy may itself change sensory feedback from muscle spindles, which could modify sensorimotor plasticity [12,33].…”

Section: Discussionmentioning

confidence: 99%

Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

et al. 2017

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Myotonic dystrophy type 1 (DM1) is the most prevalent adult muscular dystrophy, often accompanied by impairments in attention, memory, visuospatial and executive functions. Given that DM1 is a multi-system disorder, it requires a multi-disciplinary approach, including effective rehabilitation programs, focusing on the central nervous system neuroplasticity, in order to develop patient-tailored rehabilitative procedures for motor function recovery. Herein, we performed a transcranial magnetic stimulation (TMS) study aimed at investigating central motor conduction time, sensory-motor plasticity, and cortical excitability in 7 genetically defined DM1 patients. As compared to healthy individuals, DM1 patients showed a delayed central motor conduction time and an abnormal sensory-motor plasticity, with no alteration of cortical excitability. These findings may be useful to define patient-tailored motor rehabilitative programs.

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“…In a rat model of compulsive drug seeking, prolonged cocaine self-administration decreased intrinsic excitability of deep-layer mPFC pyramidal neurons, which was especially pronounced in compulsive drug-seeking animals; compensating for this hypoactivity of these projection neurons with in vivo optogenetic mPFC stimulation prevented compulsive cocaine seeking, and the authors suggested this could represent “a promising therapy for treating compulsive drug use” (Figure 2F; Chen et al, 2013). Recent pilot clinical studies using TMS as the clinical interventional tool now indeed suggest that stimulation of the dorsolateral prefrontal cortex reduces cocaine use in human cocaine abusers (Terraneo et al, 2016; Ferenczi and Deisseroth, 2016) and curbs cue-induced craving in human heroin addicts (Shen et al, 2016). Potential causal brainwide mechanisms for this effect have been described (Ferenczi et al, 2016), discussed in more detail below.…”

Section: Introductionmentioning

confidence: 99%

“…Terraneo et al, 2016; Shen et al, 2016; Ferenczi and Deisseroth, 2016) will encourage further innovative uses of circuit knowledge. However, as with any other therapy, a circuit-targeting treatment may not be applicable to every patient suffering from a particular symptom domain or disorder.…”

Section: Introductionmentioning

confidence: 99%

Targeting Neural Circuits

Rajasethupathy

Ferenczi

Deisseroth

2016

Cell

151

111

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Current optogenetic methodology enables precise inhibition or excitation of neural circuits, spanning timescales as needed from the acute (milliseconds) to the chronic (many days or more), for experimental modulation of network activity and animal behavior. Such broad temporal versatility, unique to optogenetic control, is particularly powerful when combined with brain activity measurements that span both acute and chronic timescales as well. This enables, for instance, the study of adaptive circuit dynamics across the intact brain, and tuning interventions to match activity patterns naturally observed during behavior in the same individual. Although the impact of this approach has been greater on basic research than on clinical translation, it is natural to ask if specific neural circuit activity patterns discovered to be involved in controlling adaptive or maladaptive behaviors could become targets for treatment of neuropsychiatric diseases. Here we consider the landscape of such ideas related to therapeutic targeting of circuit dynamics, taking note of developments not only in optical but also in ultrasonic, magnetic, and thermal methods. We note the recent emergence of first-in-kind optogenetically-guided clinical outcomes, as well as opportunities related to the integration of interventions and readouts spanning diverse circuit-physiology, molecular, and behavioral modalities.

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10-Hz Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex Reduces Heroin Cue Craving in Long-Term Addicts

Cited by 123 publications

References 13 publications

The left dorsolateral prefrontal cortex and caudate pathway: New evidence for cue-induced craving of smokers

The left dorsolateral prefrontal cortex and caudate pathway: New evidence for cue-induced craving of smokers

Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

Targeting Neural Circuits

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