10-Hydroxy Decanoic Acid-Based Vesicles as a Novel Topical Delivery System: Would It Be a Better Platform Than Conventional Oleic Acid Ufasomes for Skin Cancer Treatment?

Abstract

10-hydroxy decanoic acid (HDA), a naturally derived fatty acid, was used for the preparation of novel fatty acid vesicles for comparison with oleic acid (OA) ufasomes. The vesicles were loaded with magnolol (Mag), a potential natural drug for skin cancer. Different formulations were prepared using the thin film hydration method and were statistically evaluated according to a Box–Behnken design in terms of particle size (PS), polydispersity index (PDI), zeta potential (ZP), and entrapment efficiency (EE). The ex vivo skin permeation and deposition were assessed for Mag skin delivery. In vivo, an assessment of the optimized formulae using 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin cancer in mice was also conducted. The PS and ZP of the optimized OA vesicles were 358.9 ± 3.2 nm and −82.50 ± 7.13 mV compared to 191.9 ± 6.28 nm and −59.60 ± 3.07 mV for HDA vesicles, respectively. The EE was high (>78%) for both types of vesicles. Ex vivo permeation studies revealed enhanced Mag permeation from all optimized formulations compared to a drug suspension. Skin deposition demonstrated that HDA-based vesicles provided the highest drug retention. In vivo, studies confirmed the superiority of HDA-based formulations in attenuating DMBA-induced skin cancer during treatment and prophylactic studies.

Oleic Acid sebagai Terapi Komplementer Kanker

“…Gambar 1. Struktur senyawa Oleic acid (Atef et al, 2023) Metode ekstraksi OA Senyawa anti kanker yang berasal dari bahan alami akan didapatkan setelah melalui metode ekstraksi dan analisis kandungan senyawa. Ekstraksi adalah tahap pertama untuk memisahkan produk alami yang diinginkan dari bahan baku.…”

Design and Evaluation of Tretinoin Fatty Acid Vesicles for the Topical Treatment of Psoriasis

“…Fatty acid vesicles (FAVs) are closed binary-layer aggregates formed by fatty acids and their ionic compound self-assembly. In addition, due to their high solubility, FAVs ensure excellent separation in various biological membranes [20,21]. Fatty acids are abundant in the skin, which help to strengthen the skin's barrier strength and can be employed as an effective skin-penetration enhancer [22,23].…”