Abstract:Apolipoprotein E (apoE) belongs to a large heterogeneous family of lipid-binding proteins and is produced by a variety of tissues including the brain and liver where it subserves a diversity of functions. The primary metabolic role of apoE is as a key regulator of cholesterol and triglyceride transport between cells. It has three isoforms, E2, E3 and E4, and genetic variation in the distribution of these isoforms are associated with plasma lipid levels and atherosclerosis; the E4 isoform is also associated wit… Show more
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