1-Nitro-4-(1-propyn-1-yl)benzene

Fernandez, Cristian Saul Campos; Pineda, Leslie W.; Pizarro, J. Cabezas

doi:10.1107/s2414314619015852

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2020

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“…We elucidated the crystal structure for 1-nitro-4-(propyn-1yl)benzene (16). 45 Particularly relevant was the synthesis of the biologically active N-[3-(propyn-1-yl)phenyl]benzenesulfonamide (18) in 97% yield from iodide 17 (Table 2, entry 4). In addition to elucidating its crystal structure, 46 we tested the antibacterial activity of sulfonamide 18 against Staphylococcus aureus and Escherichia coli, and obtained minimum inhibitory concentrations (MIC) of 12.5 g/mL and 25.0 g/mL, respectively.…”

Section: Paper Syn Thesismentioning

confidence: 99%

Regiospecific Palladium-Catalyzed Cross-Coupling Reactions Using the Operational Equivalent of 1,3-Dilithiopropyne

Cabezas

Ferllini²

2020

Synthesis

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A regiospecific palladium-catalyzed cross-coupling reaction using the operational equivalent of the dianion 1,3-dilithiopropyne, with aromatic iodides is reported. This reaction gives high yields of 1-propyn-1-yl-benzenes and 2-(propyn-1-yl)thiophenes in the presence of catalytic amounts of palladium(0) or (II) and stoichiometric amounts of copper iodide. No terminal alkyne or allene isomers were detected. Reaction conditions were very mild and several functional groups were tolerated.

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Section: Paper Syn Thesismentioning

confidence: 99%