1. Mitteilung über Valeriana. Die Isolierung von Hesperitinsäure, Behensäure und von Zwei Unbekannten Säuren aus Baldrian

Stoll, A.; Seebeck, E.

doi:10.1002/jlac.19576030117

Cited by 24 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with an earlier study (Hansel and Schulz, 1982), in which 7 was not detected in 50 samples of roots and rhizomes of K officinalis, the crude material for the preparation of valerian tinctures. However, 7 has been detected by others (Stoll and Seebeck, 1957;Hansel and Schulz, 1985;Closson et al, 1992). Schimmer and Roder (1 992) detected 6 and 8 by TLC in 19 out of 23 commercial plant drugs, and all three compounds (6-8) have been detected in several extracts by Hansel and Schulz (1985).…”

Section: Analysis Of Valerian-containing Phytomedicinesmentioning

confidence: 91%

See 1 more Smart Citation

Analytical Aspects of Phytotherapeutic Valerian Preparations

et al. 1996

View full text Add to dashboard Cite

A high performance liquid chromatographic method combined with diode array detection is described by which the valerian constituents valtrate, isovaltrate, acevaltrate, didrovaltrate, isovaleroxyhydroxydidrovaltrate, valerenic acid, hydroxyvalerenic acid and acetoxyvalerenic acid, as well as the valepotriate decomposition products baldrinal and homobaldrinal, can be separated and identified simultaneously. Using this procedure, roots of Valeriana officinalis, which are used for the production of phytomedicines, were analysed. The influence of different ethanol:water mixtures, used as extraction liquid, on the composition of extracts of V. officinalis is reported. The analytical procedure was also applied to a number of valerian‐containing phytomedicines available on the Dutch market. In order to study the stability of the valepotriates and the formation of their decomposition product(s), samples of freshly prepared valerian tinctures were analysed after being stored at 4, 20, and 36°C for up to one month.

show abstract

Section: Analysis Of Valerian-containing Phytomedicinesmentioning

confidence: 91%

“…Valerenic acid (6). hydroxyvalerenic acid (7) and acetoxyvalerenic acid (8) were isolated from V oficinalis according to Stoll and Seebeck (1957). Isovaleroxyhydroxydidrovaltrate (5) was obtained from LAT GmbH Dr. Tittel.…”

Section: ~~ ~ ~ ~~mentioning

confidence: 99%

Analytical Aspects of Phytotherapeutic Valerian Preparations

et al. 1996

View full text Add to dashboard Cite

show abstract

“…376 Valerenic acid acts as a subtype-selective g-aminobutyric acid type A (GABA A ) receptor (GABA A R) agonist. 377 Since GABA A R is an ionotropic receptor and ligand-gated ion channel, and its endogenous ligand is g-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, valerenic acid may thus be useful in the treatment of various dysfunctions of the central nervous system.…”

Section: Ir-catalyzed Hydrogenation In Stereoselective Synthesesmentioning

confidence: 99%

Stereoselective Hydrogenation ofCCBonds: Application to Drug and Natural Product Synthesis

Andrushko

2013

Stereoselective Synthesis of Drugs and Natural Products

View full text Add to dashboard Cite

Asymmetric homogeneous hydrogenation is perhaps one of the most researched areas in homogeneous catalysis; thus, it is now used in numerous innovative applications in stereoselective syntheses of many chiral pharmaceutical and natural products. Metal complexes, derived from transition metals, like Rh, Ru, Ir, and so on, and chiral ligands (usually mono‐ or diphosphine ligands), are widely used as catalysts in asymmetric alkene hydrogenation as a result of their efficiency in the preparation of enantiopure compounds with excellent atom economy. This chapter provides many interesting examples of homogeneous enantio‐ and diastereoselective hydrogenation of CC bonds, highlighting the utility of these methods as useful synthetic tools for the construction of stereogenic centers in stereoselective drug and natural product syntheses.

show abstract

“…The available evidence suggests that The active constituents for sedative pharmaceutical activity from V. officinalis, V. wallichii, V. sisymbriifolia and V. celtica, including essential oils, valepotriates, valerenic acid and derivative, were investigated in the past one hundred years (Stoll & Seebeck, 1957;Thies, 1966;Bos et al, 1997a;Novak et al, 2000;Schumacher et al, 2002;Marder et al, 2003;Cecilia et al, 2009;Javidnia et al, 2010). Owing to containing a great quantity volatile constituents, the essential oils were usually analysed by capillary GC, GC-MS and other instruments (Gränicher et al, 1995;Bos et al, 1997b;Kovacevic et al, 2002;Sati & Mathela, 2005;Safaralie et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes of the main active constituents in valerian rhizome and root /Valeriana amurensis Smir. ex Kom.) during different harvest periods

Wu¹,

Huo²,

Yu³

et al. 2019

Bol Latinoam Caribe Plant Med Aromat

View full text Add to dashboard Cite

Artículo Original | Original Article 518 Dynamic changes of the main active constituents in valerian rhizome and root (Valeriana amurensis Smir. ex Kom.) during different harvest periods [Cambios dinámicos de los principales constituyentes activos del rizoma y raíz valeriana (Valeriana amurensis Smir. Ex Kom.) durante diferentes períodos de cosecha]Abstract: Valeriana amurensis Smir. ex Kom. widely distributed in the northeast region of China and some region in Russia and Korea, and its underground parts (roots and rhizomes) being used to cure nervous system diseases such as insomnia. The active components including the essential oil and iridoids of underground parts were investigated in different harvest periods in order to evaluate the quality for the roots and rhizomes of V. amurensis. The content of the essential oil was obtained by hydrodistillation and bornyl acetate in the oil was quantitated by GC-EI. The iridoids, valepotriates were determined by potentiometric titration and the main component, valtrate was quantitated by HPLC-UV. The factors of biomass were considered in the determination of collection period. Statistical analysis of results showed that, the highest content of the essential oil per plant was 22.69 µl in withering period and then 21.58 µl in fruit ripening period, while the highest contents of bornyl acetate, valepotriates and valtrate per plant were 2.82 mg, 31.90 mg and 0.98 mg in fruit ripening period separately. Fruit ripening period was decided as the best harvest period for the content of active constituents and output of drug, and it would provide scientific basis for the artificial cultivation of V. amurensis.Resumen: Valeriana amurensis Smir. ex Kom. Se distribuye ampliamente en la región noreste de China y en algunas regiones de Rusia y Corea, y sus partes subterráneas (raíces y rizomas) se utilizan para curar enfermedades del sistema nervioso como el insomnio. Se investigaron los componentes activos, incluidos el aceite esencial y los iridoides de las partes subterráneas de V. amurensis en diferentes períodos de cosecha para evaluar la calidad de las raíces y rizomas. El contenido del aceite esencial se obtuvo mediante hidrodestilación y el acetato de bornilo en el aceite se cuantificó por GC-EI. Los iridoides, valepotriatos se determinaron mediante valoración potenciométrica y el componente principal, el valtrato se cuantificó por HPLC-UV. Los factores de biomasa fueron considerados en la determinación del período de recolección. El análisis estadístico de los resultados mostró que el mayor contenido de aceite esencial por planta fue de 22,69 µl en el período de marchitación y luego de 21,58 µl en el período de maduración de la fruta, mientras que el mayor contenido de acetato de bornilo, valepotriatos y valtrato por planta fue de 2.82 mg, 31.90 mg y 0,98 mg, respectivamente, en el período de maduración de la fruta por separado. Se definió el período de maduración de la fruta como el mejor período de cosecha para el contenido de constituyentes activos y la producción de droga...

show abstract

1. Mitteilung über Valeriana. Die Isolierung von Hesperitinsäure, Behensäure und von Zwei Unbekannten Säuren aus Baldrian

Cited by 24 publications

References 9 publications

Analytical Aspects of Phytotherapeutic Valerian Preparations

Analytical Aspects of Phytotherapeutic Valerian Preparations

Stereoselective Hydrogenation ofCCBonds: Application to Drug and Natural Product Synthesis

Dynamic changes of the main active constituents in valerian rhizome and root /Valeriana amurensis Smir. ex Kom.) during different harvest periods

Contact Info

Product

Resources

About