1-Methylisoguanosine: An orally active marine natural product with skeletal muscle and cardiovascular effects

Baird-Lambert, J.; Marwood, John F.; Davies, Leo; Taylor, KM

doi:10.1016/0024-3205(80)90253-2

Cited by 61 publications

(18 citation statements)

References 5 publications

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“…In recent years the behavioural actions of adenosine and its metabolically stable derivatives have been studied in increasing detail. As well as having sedative, hypothermic, antinociceptive, and muscle relaxant properties, several of these compounds have relatively potent anticonvulsant actions in rodents (Maitre et al, 1974;Baird-Lambert et al, 1980;Snyder et al, 1981 ;Yarbrough and McGuffin-Clineschmidt, 1981;Dunwiddie and Worth, 1982).…”

mentioning

confidence: 99%

Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 2. Pharmacological Studies

1983

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The interactions of carbamazepine with adenosine receptors were studied in two pharmacological systems. In the isolated guinea pig ileum, several adenosine agonists and carbamazepine potently inhibited nicotine-stimulated and electrically stimulated contractions in a manner sensitive to the adenosine antagonist theophylline. High concentrations of carbamazepine were able to reduce the inhibition of electrically stimulated contractions by the adenosine agonist l-methylisoguanosine. The ability of theophylline to reduce the anticonvulsant efficacy of several drugs against pentylenetetrazole-induced seizures in mice was investigated. Theophylline pretreatment failed to alter anticonvulsant protection by trimethadione and sodium valproate, but significantly decreased the anticonvulsant effects of carbamazepine and phenobarbital. These results suggest that carbamazepine may exert some of its anti-convulsant effects by acting as a partial agonist at adenosine receptors.

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mentioning

confidence: 99%

Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 2. Pharmacological Studies

1983

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“…Furthermore, we have not ruled out that the effects observed might be somehow related to side effects of CADO as fall in blood pressure. However, cardiovascular responses to injection of purine analogs directly into the lateral ventricles have been shown to be smaller than those seen after peripheral injection (Baird-Lambert et aL, 1980).…”

Section: Discussionmentioning

confidence: 96%

Effects of 2-Chloroadenosine on hippocampal GABA content and turnover

Zambotti

Zonta

Ferrario

et al. 1986

J. Neural Transmission

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SummaryThe effects of 2-Chloroadenosine (CADO), a stable analog of adenosine, on GABA turnover rate and GABA content in the rat hippocampus in vivo have been studied. The intracerebroventricular injection of CADO reduced the GABA turnover rate in the hippocampus, as estimated from the rate of GABA accumulation after inhibition ofGABA transaminase (GABA-T) by aminooxyacetic acid (AOAA). The effect of CADO on AOAA-induced accumulation of GABA in the hippocampus was blocked by the intraperitoneal injection of the adenosine receptor antagonist caffeine. Furthermore, CADO at the dose of 5/xg per ventricle produced a significant decrease in GABA content in the hippocampus. Our results support the hypothesis that adenosine exerts inhibitory effects on GABAergic circuits in the hippocampus.

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“…51 And there is a positive correlation between the potency of resistance to adenosine deaminase and the muscle relaxation and cardiovascular effects. 30,51,178 However, in 1985, Radulovacki 179 et al reported 1methyl-isoG does not have a strong hypnosis effect similar to showed that 1-methyl-isoG has equal negative inotropic and chronotropic effects in guinea-pig isolated atria. Nevertheless, adenosine has a greater negative inotropic effect.…”

Section: Applications Of Isog Mispairingmentioning

confidence: 98%

“…These have drawn attention toward isoguanine as a marker for oxidative damage formation, repair, mutagenicity. [29][30][31][32][33][34] In 2002, Cadet 35 et al demonstrated that aer g-ray radiolysis and Fenton reaction of free nucleosides, the yield of 2 0deoxyisoguanosine (isoG d ) was low, compared to the yield of 8oxo-2 0 -deoxy-adenosine, expect in the presence of ferrous ion (Fe 2+ )/ethylenediaminetetraacetic acid (EDTA) with oxygen or cuprous ion (Cu + ). However, Fe 2+ /EDTA with oxygen or Cu + are typically at very different conditions from those found in cells.…”

Section: Discovery Process Of Isogmentioning

confidence: 99%

“…30,50,51,56,[174][175][176][177] In 1981, as shown in Table 5, a comparison of effects of the derivatives of 1methyl-isoG have been explored by Cook 56 et al Moreover, the effects of halogenated analog 2-chloroadenosine are greater. 30 These effects induced by 1-methyl-isoG are more potent than adenosine because 1-methyl-isoG can resist the action of adenosine deaminase. So 1-methyl-isoG can exist in the extracellular uid for a long time, whereas adenosine has been degraded into inactive inosine.…”

Section: Applications Of Isog Mispairingmentioning

confidence: 99%

See 1 more Smart Citation

The development of isoguanosine: from discovery, synthesis, and modification to supramolecular structures and potential applications

Ding

Tang

et al. 2020

RSC Adv.

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1-Methylisoguanosine: An orally active marine natural product with skeletal muscle and cardiovascular effects

Cited by 61 publications

References 5 publications

Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 2. Pharmacological Studies

Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 2. Pharmacological Studies

Effects of 2-Chloroadenosine on hippocampal GABA content and turnover

The development of isoguanosine: from discovery, synthesis, and modification to supramolecular structures and potential applications

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