1-Methoxypyrrole-2-carboxamide—A new pyrrole compound isolated from &lt;i&gt;Streptomyces griseocarneus&lt;/i&gt; SWW368

Wattanasuepsin, Watsapon; Intra, Bungonsiri; Euanorasetr, Jirayut; Watanabe, Yoshihiro; Mingma, Ratchanee; Fukasawa, Wataru; Mori, Masayuki; Matsumoto, Atsuko; Shiomi, Kazuro; Panbangred, Watanalai

doi:10.2323/jgam.2016.10.006

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…Many Streptomyces spp. were reported to produce various volatile compounds that were effective against the anthracnose disease in various crops [ 82 ]. The volatile compounds from Streptomyces philanthi RM-1-138 and Streptomyces spp.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Potentiality of Native Actinobacteria to Combat the Chilli Fruit Rot Pathogens under Post-Harvest Pathosystem

Renuka

Prabakar

Anandham

et al. 2023

Life

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Chilli is an universal spice cum solanaceous vegetable crop rich in vitamin A, vitamin C, capsaicin and capsanthin. Its cultivation is highly threatened by fruit rot disease which cause yield loss as high as 80–100% under congenial environment conditions. Currently actinobacteria are considered as eco-friendly alternatives to synthetic fungicides at pre and post-harvest pathosystems. Hence, this research work focuses on the exploitation of rhizospheric, phyllospheric and endophytic actinobacteria associated with chilli plants for their antagonistic activity against fruit rot pathogens viz., Colletotrichum scovillei, Colletotrichum truncatum and Fusarium oxysporum. In vitro bioassays revealed that the actinobacterial isolate AR26 was found to be the most potent antagonist with multifarious biocontrol mechanisms such as production of volatile, non-volatile, thermostable compounds, siderophores, extracellular lytic enzymes. 16S rRNA gene sequence confirmed that the isolate AR26 belongs to Streptomyces tuirus. The results of detached fruit assay revealed that application of liquid bio-formulation of Stretomyces tuirus @ 10 mL/L concentration completely inhibited the development of fruit rot symptoms in pepper fruits compared to methanol extracts. Hence, the present research work have a great scope for evaluating the biocontrol potential of native S. tuirus AR26 against chilli fruit rot disease under field condition as well against a broad spectrum of post-harvest plant pathogens.

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Section: Discussionmentioning

confidence: 99%

Exploring the Potentiality of Native Actinobacteria to Combat the Chilli Fruit Rot Pathogens under Post-Harvest Pathosystem

Renuka

Prabakar

Anandham

et al. 2023

Life

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“…Conversely, there are also many antibiotics which have been elucidated from crude cell culture extracts but have not been linked with the corresponding gene cluster—iminimycin A and 1‐methoxypyrrole‐2‐carboxamide (from S. griseus and Streptomyces griseocarneus , respectively) are examples of this. “Orphan products” (not linked to a gene cluster) may be interesting to investigate in the future for improvement of yield or strength, especially with the advent of Pep2Path for the mass‐spectrometry‐based mining of novel peptide metabolites . A high‐throughput screening platform termed “SLAY” (Surface Localized Antimicrobial Display) has also recently been published for the testing of novel peptide antimicrobials .…”

Section: Discussionmentioning

confidence: 99%

“…"Orphan products" (not linked to a gene cluster) may be interesting to investigate in the future for improvement of yield or strength, especially with the advent of Pep2Path for the massspectrometry-based mining of novel peptide metabolites. [142][143][144] A high-throughput screening platform termed "SLAY" (Surface Localized Antimicrobial Display) has also recently been published for the testing of novel peptide antimicrobials. [145] There is also a wealth of previously uncultivated bacteria which may yield novel antibiotics: Eleftheria terrae yielding the new cell wall-precursor-binding antibiotic teixobactin is a good example.…”

Section: Discussionmentioning

confidence: 99%

The “Three Cs” of Novel Antibiotic Discovery and Production through Synthetic Biology: Biosynthetic Gene Clusters, Heterologous Chassis, and Synthetic Microbial Consortia

2018

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Antimicrobial resistance is a rapidly growing problem worldwide, with bacteria showing resistance to last‐resort antibiotic treatments such as carbapenems and colistin becoming more abundant. Synthetic biology may be able to contribute to solving this growing antimicrobial resistance crisis by facilitating the engineering of diversified collections of novel antibiotics, targeting multidrug resistant bacteria in new ways. This review discusses recent advances in the use of synthetic biology methodologies to discover and produce novel antimicrobials; in particular, the work being carried out on biosynthetic gene clusters, heterologous chassis, and synthetic microbial consortia, the “three Cs” of the title.

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“…oryzae; nevertheless, it was not shown to be harmful at concentrations of 714 mM to several mammalian tumor cell lines, including A549, PANC1, HT29, HT1299, and HeLa S3. [133] The natural product containing pyrrole unit, with a MIC value of 8.35 μg/mL, compound 80 exhibits promising antibacterial activity against S. aureus. [134] The fused compound 81 and 82 shows good antibacterial activity against S. aureus and E. coli; these compounds have good binding affinity with energy 8.00 and 8.80 Kcal/mol.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Pyrrole ring having a main amide group and a N ‐methoxy group and it has antibacterial effects against Kocuria rhizophila , Staphylococcus aureus , and Xanthomonas campestris pv. oryzae ; nevertheless, it was not shown to be harmful at concentrations of 714 mM to several mammalian tumor cell lines, including A549, PANC1, HT29, HT1299, and HeLa S3 [133] . The natural product containing pyrrole unit, with a MIC value of 8.35 μg/mL, compound 80 exhibits promising antibacterial activity against S. aureus [134] .…”

Section: Pyrroles Against Infectious Diseasesmentioning

confidence: 99%

Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure‐Activity Relationship

Ganesh,

Raj,

Aruchamy

et al. 2023

ChemMedChem

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An overview of pyrroles as distinct scaffolds with therapeutic potential and the significance of pyrrole derivatives for drug development are provided in this article. It lists instances of naturally occurring pyrrole‐containing compounds and describes the sources of pyrroles in nature, including plants and microbes. It also explains the many conventional and modern synthetic methods used to produce pyrroles. The key topics are the biological characteristics, pharmacological behavior, and functional alterations displayed by pyrrole derivatives. It also details how pyrroles are used to treat infectious diseases. It describes infectious disorders resistant to standard treatments and discusses the function of compounds containing pyrroles in combating infectious diseases. Furthermore, the review covers the uses of pyrrole derivatives in treating non‐infectious diseases and resistance mechanisms in non‐infectious illnesses like cancer, diabetes, and Alzheimer's and Parkinson's diseases. The important discoveries and probable avenues for pyrrole research are finally summarized, along with their significance for medicinal chemists and drug development. A reference from the last two decades is included in this review.

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1-Methoxypyrrole-2-carboxamide—A new pyrrole compound isolated from <i>Streptomyces griseocarneus</i> SWW368

Cited by 6 publications

References 13 publications

Exploring the Potentiality of Native Actinobacteria to Combat the Chilli Fruit Rot Pathogens under Post-Harvest Pathosystem

Exploring the Potentiality of Native Actinobacteria to Combat the Chilli Fruit Rot Pathogens under Post-Harvest Pathosystem

The “Three Cs” of Novel Antibiotic Discovery and Production through Synthetic Biology: Biosynthetic Gene Clusters, Heterologous Chassis, and Synthetic Microbial Consortia

Pyrrole: A Decisive Scaffold for the Development of Therapeutic Agents and Structure‐Activity Relationship

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