1 Megakaryocyte and platelet morphology

Hovig, Torstein

doi:10.1016/s0950-3536(89)80032-0

Cited by 10 publications

(3 citation statements)

References 145 publications

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“…platelet factor 4 (18)(19)(20)(21). These may variously suppress or enhance the response of endothelial cells to cytokines and a possible role for selective downregulation of ELAM-1 but not ICAM-1 on HUVEC by other platelet products is currently under investigation.…”

Section: Failure To Stimulate Expression Of the Il-1 Inducible Adhesimentioning

confidence: 99%

“…Following activation, platelets express or release a variety of mediators in addition to IL-1 including transforming growth factor beta, thrombospondin, ~2 thromboglobulin, and platelet factor 4 (18)(19)(20)(21). These may variously suppress or enhance the response of endothelial cells to cytokines and a possible role for selective downregulation of ELAM-1 but not ICAM-1 on HUVEC by other platelet products is currently under investigation.…”

Section: Failure To Stimulate Expression Of the Il-1 Inducible Adhesion Molecule Elam-1 On Huvec But Not Savec Demonstrated A Surprising mentioning

confidence: 99%

See 1 more Smart Citation

Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production.

Hawrylowicz

Howells

Feldmann

1991

The Journal of Experimental Medicine

200

118

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Sllmmal'yInterleukin 1 (IL-1) plays a central role in the regulation of the body's response to infectious and inflammatory stimuli. Recent evidence has shown that human platelets express a cell associated form of this proinflammatory cytokine very rapidly following activation. Since one of the earliest events in inflammation is frequently the rapid adhesion of platelets to injured endothelium, it was of interest to determine whether platelets express IL-1 in a functionally relevant form that can alter the phenotype of human endothelial cells in vitro. Thrombin activated platelets induced significant expression of the adhesion molecule intercellular adhesion molecule 1, as well as secretion of the IL-1 inducible cytokines Ib6 and granulocyte macrophage colony stimulating factor by cultured human umbilical cord and saphenous vein endothelial cells. This was inhibited by prior treatment of the platelets with antibody specific for Ibl, These results suggest that platelet delivered IL-1 might initiate and regulate some of the earliest phases of the inflammatory response. An additional observation of interest was differential induction of endothelial leucocyte adhesion molecule I by activated platelets on saphenous vein but not umbilical vein endothelial cells, which suggests functional heterogeneity of the endothelial cells.

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Section: Failure To Stimulate Expression Of the Il-1 Inducible Adhesimentioning

confidence: 99%

Section: Failure To Stimulate Expression Of the Il-1 Inducible Adhesion Molecule Elam-1 On Huvec But Not Savec Demonstrated A Surprising mentioning

confidence: 99%