1-Hz rTMS in the treatment of tinnitus: A sham-controlled, randomized multicenter trial

Landgrebe, Michael; Hajak, Göran; Wolf, Stefan; Padberg, Frank; Klupp, Philipp; Fallgatter, Andreas J.; Polak, Thomas; Höppner, Jacqueline; Haker, Rene; Cordes, Joachim; Klenzner, Thomas; Schönfeldt‐Lecuona, Carlos; Kammer, Thomas; Graf, Erika; Koller, Michael; Kleinjung, Tobias; Lehner, Astrid; Schecklmann, Martin; Pöppl, T.; Kreuzer, Peter; Frank, Elmar; Langguth, Berthold

doi:10.1016/j.brs.2017.08.001

Cited by 44 publications

(89 citation statements)

References 55 publications

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“…Second, although we have found that tDCS-TMS has the potential to improve the neuromodulatory effect, thereby creating an improvement of tinnitus, the results are limited as we have utilized only 200 pulses of low-frequency TMS due to time and space constraints in our hospital. Most of the previous tinnitus studies utilizing low-frequency TMS used 2,000 stimuli (46)(47)(48). In this regard, future tDCS-TMS studies using conventional TMS with 2,000 stimuli should be performed to explore further additive neuromodulatory effects on tinnitus.…”

Section: Discussionmentioning

confidence: 99%

Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus

Bae

Lee²,

Song

2020

Front. Neurol.

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Section: Discussionmentioning

confidence: 99%

Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus

Bae

Lee²,

Song

2020

Front. Neurol.

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“…2 and 3) presents each item for each included study as well as each item presented as percentages across all included trails according to our established quality evaluation standard. Of the included studies, 3 reported [16,24,26] the THI scores 1 week after intervention.Because of nonsigni cant heterogeneity among the studies, the xed effect model was utilized (I 2 = 0%, P = 0.57).…”

Section: Study Characteristics and Methodological Qualitymentioning

confidence: 99%

“…9) 3.3.7. Other Outcome Evaluation Indicators Two studies [16,26] reporting statistics on TQ scores 1 week after intervention,2 studies [16,26] reporting statistics on TQ scores 1 month after intervention were involved in meta-analysis,2 studies [15,26] reporting statistics on TQ scores 6 months after intervention, 3 studies [4,16] (One study [4] included two RCTs)…”

Section: 6mean Change In Thi Scores 6 Months After Interventionmentioning

confidence: 99%

“…reporting statistics on mean change in TQ scores 1 week after intervention,2 studies [17,26] reporting statistics on VAS scores 1 month after intervention and 2 studies [16,17] reporting statistics on tinnitus loudness 1 month after intervention were involved in meta-analysis,The results exhibited a statistically signi cant differences in TQ scores 1 week after intervention between the two patient groups (P = 0.02).However, It was found that the difference in other outcome after intervention were no signi cant between the two patient groups (MD: -6.53, 95%CI: -11.40,-1.66, P = 0.009). (Table.4) 3…”

Section: 6mean Change In Thi Scores 6 Months After Interventionmentioning

confidence: 99%

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Repetitive Transcranial Magnetic Stimulation (RTMS) on Chronic Tinnitus: a Systematic Review and Meta-Analysis

Liang

Gang

Huang

et al. 2020

Preprint

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Background:Although the clinical efficacy and safety of repeated transcranial magnetic stimulation(rTMS)on the treatment of chronic tinnitushave been frequently reported, the results remain controversial.Therefore, its relatedclinical efficacy and safety were systematically evaluated and meta-classified in this study.Methods:Literature on repeated transcranial magnetic stimulation(rTMS)on chronic tinnitus was retrieved in PubMed, Embase and Cochrane Library due April 2020.Review Manager 5.3 software was appliedto data synthesis, and Stata 13.0 software was adopted for analyses of publication bias and sensitivity.Results:A total of 29randomized studies with 1,228 patients were included. Compared with sham rTMS, rTMSshowed statistical significance in tinnitus handicap inventory(THI) scores 1 week after intervention (MD-7.92, 95% condidence interval [CI] -14.18,-1.66), THI scores 1month after intervention (MD-8.52, 95% CI -12.49,-4.55),THI scores 6months after intervention (MD-6.53, 95% CI -11.406,-1.66), TQ scores 1 week after intervention (MD-8.54, 95% CI -15.56,-1.52),mean change in THI scores 1month after intervention(MD-14.86, 95% CI -21.42,-8.29) and mean change in THI scores 6months after intervention(MD-16.37, 95% CI -20.64,-12.11) .There was no statistical difference between rTMS and sham rTMS in THI scores 2 week after intervention (MD-1.51, 95% CI -13.42,-10.40),tinnitus questionnaire(TQ) scores 1 month after intervention (MD-8.97, 95% CI -20.41,2.48),TQ scores 6 months after intervention (MD-7.02, 95% CI -18.18,4.13) , mean change in TQ scores 1months after intervention(MD-3.67, 95% CI -8.56,1.22) and adverse events (OR 1.11, 95% CI 0.51,2.42).Egger's and Begg's testsindicatedno publication bias(P= 0.925).Conclusion:It was demonstrated that rTMS on chronic tinnitus has certain clinical curative effect and high safety,however, due to the lack of included studies and the small sample size, more large-sample, multi-center, randomized double-blind trials are needed for further verification.

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“…Three studies [15,25,26] containing statistics for THI scores 1-week post-intervention were available for the analysis using a random-effect model, with signi cant heterogeneity among the studies (I 2 = 72%, P = 0.03). The results exhibited no statistically signi cant differences in the THI score 2-week post-intervention between the two groups (MD:-1.51, 95%CI: -13.42,10.40, P = 0.80).…”

Section: The Thi Scores 2-week Post-interventionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation on Chronic Tinnitus: A Systematic Review and Meta-Analysis

Liang

Gang

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Although the clinical efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in the treatment of chronic tinnitus have been frequently examined, the results remain controversial. Therefore, we systematically meta-classified clinical trials concerning the effects of rTMS to evaluate its clinical efficacy and safety. Methods: Studies of rTMS for chronic tinnitus were retrieved in PubMed, Embase, and Cochrane Library due April 2020. Review Manager 5.3 software was employed for data synthesis and Stata 13.0 software for analyses of publication bias and sensitivity. Results: Twenty-nine randomized studies representing 1,228 chronic tinnitus patients were included. Compared with sham-rTMS, rTMS exhibited significant improvements in the tinnitus handicap inventory (THI) score 1-week (mean difference [MD] -7.92, 95% confidence interval [CI] -14.18,-1.66), 1-month (MD -8.52, 95% CI -12.49, -4.55), and 6-month post-intervention (MD -6.53, 95% CI -11.406,-1.66), the mean change in THI scores 1- (MD -14.86, 95% CI -21.42,-8.29) and 6-month post-intervention (MD -16.37, 95% CI -20.64,-12.11), and the tinnitus questionnaire (TQ) score 1-week post-intervention (MD -8.54, 95% CI -15.56,-1.52). Non-significant efficacy of rTMS was found concerning the THI score 2-week post-intervention (MD -1.51, 95% CI -13.42,-10.40), the mean change in TQ scores 1-month post-intervention (MD -3.67, 95% CI -8.56,1.22), the TQ score 1- (MD -8.97, 95% CI -20.41,2.48) and 6-month post-intervention (MD -7.02, 95% CI -18.18,4.13), and adverse events (odds ratios [OR] 1.11, 95% CI 0.51,2.42). The Egger's and Begg's tests indicated no publication bias ( P = 0.925). Conclusion: This meta-analysis demonstrates that rTMS is effective for chronic tinnitus; however, its safety needs more validations. Restrained by the limited number of included studies and the small sample size, more large randomized double-blind multi-center trials are needed for further verification.

show abstract

1-Hz rTMS in the treatment of tinnitus: A sham-controlled, randomized multicenter trial

Cited by 44 publications

References 55 publications

Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus

Single-Session of Combined tDCS-TMS May Increase Therapeutic Effects in Subjects With Tinnitus

Repetitive Transcranial Magnetic Stimulation (RTMS) on Chronic Tinnitus: a Systematic Review and Meta-Analysis

Repetitive Transcranial Magnetic Stimulation on Chronic Tinnitus: A Systematic Review and Meta-Analysis

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