1-Hz low frequency repetitive transcranial magnetic stimulation in children with Tourette's syndrome

Kwon, Ho Jang; Lim, Won Seok; Lim, Myung Ho; Lee, Seong Jae; Hyun, Jung Keun; Chae, Jeong‐Ho; Paik, Ki Chung

doi:10.1016/j.neulet.2011.01.007

Cited by 120 publications

(84 citation statements)

References 26 publications

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“…A clinically significant improvement in TS symptoms with benefits lasting up to 6 months was seen in two of the patients, similar to that reported [19][20][21][22]. Improvement in ADHD was also seen in one patient and another one was improved in his OCD symptoms.…”

Section: Discussionsupporting

confidence: 85%

“…The degree of efficacy of rTMS treatment of tics varies between studies, but one should keep in mind that conditions vary including respect to the treatment given. There are some studies that suggest post effects [19][20][21][22], and others who do not have any significant effect on tics [23,24]. An Italian study, published in 2006, examined whether lowfrequency rTMS was able to normalize the overactive motor cortex, thereby improve tics and compulsive symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…None of the participants had any side effects from the treatment [25]. In an open label 12 weeks cohort pilot study by Kwon et al, 1 Hz rTMS was applied over the SMA (Supplemental Motor Area) for 10 days [22]. At the end of each day subjects completed objective ratings of ADHD, mood, anxiety, tics, and side effects.…”

Section: Introductionmentioning

confidence: 99%

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Low-frequent Repetitive Transcranial Magnetic Stimulation (rTMS) inAdolescents with Tourette Syndrome

Khalifa¹,

K²

2017

Neonat Pediatr Med

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Objective: The pathophysiology of Tourette syndrome (TS), a chronic motor and vocal tic disorder remains unknown, however abnormalities in basal ganglia-thalamo-cortical circuits presumably play an important role. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive method for modulation of cortical activity, has been applied in different ways in patients with TS.Methods: Open-label pilot study of active rTMS. Four adolescents with TS participated in the pilot study, two females and two males. The patients fulfilled DSM IV criteria for TS, and had tried psychological and/or pharmacological therapy without effects on symptoms. The rTMS treatment consisted of 10 treatment sessions Monday to Friday during a two-week period. Follow-up was done one, three and six months after finishing the treatment with rTMS.Results: There was clinically significant improvement in TS symptoms with benefits lasting up to 6 months in two of the patients. In addition, improvement in ADHD was seen in one patient, and improvement in OCD symptoms in another. There were no side effects. Conclusions:Low-frequency rTMS may be effective in children with TS. Further studies using rTMS in TS are warranted. Careful consideration of target regions and stimulation parameters, longer follow-up, and use of a double-blind, sham-controlled design may allow us to draw founded conclusions in the future.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Low-frequent Repetitive Transcranial Magnetic Stimulation (rTMS) inAdolescents with Tourette Syndrome

Khalifa¹,

K²

2017

Neonat Pediatr Med

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“…Several studies have described reductions of tic severity by repetitive TMS over the SMA, [47][48][49] although there is no consensus. 50 Bäumer et al 51 found abnormal functional interhemispheric connectivity in TS accompanied by an altered structure-function relationship in the motor corpus callosum in a combined TMS and diffusion-tensor MRI study with stimuli in hand muscles.…”

Section: Tmsmentioning

confidence: 99%

Functional neuroimaging in Tourette syndrome: recent perspectives

Debes¹,

Préel²,

Skov³

2017

NAN

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“…All subjects completed the trial with no untoward effects and no worsening in symptoms of ADHD, depression, or anxiety. Tic symptoms improved over the course of 12 weeks based on the Yale Global Tourette ' s Syndrome Severity Scale (YGTSS) (Leckman et al, scale (Kwon et al, 2011).…”

Section: Tourette ' S Syndromementioning

confidence: 99%

Applications of transcranial magnetic stimulation (TMS) in child and adolescent psychiatry

Croarkin

Wall

Lee

2011

International Review of Psychiatry

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Transcranial magnetic stimulation (TMS) is emerging as a new treatment and neurophysiological research tool for psychiatric disorders. Recent publications suggest that this modality will also serve as a treatment and research tool in child and adolescent psychiatry. Current reports on therapeutic trials of repetitive transcranial magnetic stimulation (rTMS) in adolescents have primarily focused on depression. However, other pilot work involves the treatment of attention-defi cit/hyperactivity disorder (ADHD), autism and schizophrenia. Neurophysiological studies typically utilize single and paired-pulse TMS paradigms which index cortical excitability and inhibition. Initial studies have focused on ADHD, autism, and depression. General knowledge regarding TMS among child and adolescent psychiatrists is lacking. The aim of this review is to provide an overview of TMS in the context of child and adolescent psychiatry, discuss recent therapeutic and neurophysiological studies, and examine relevant ethical considerations.

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1-Hz low frequency repetitive transcranial magnetic stimulation in children with Tourette's syndrome

Cited by 120 publications

References 26 publications

Low-frequent Repetitive Transcranial Magnetic Stimulation (rTMS) inAdolescents with Tourette Syndrome

Low-frequent Repetitive Transcranial Magnetic Stimulation (rTMS) inAdolescents with Tourette Syndrome

Functional neuroimaging in Tourette syndrome: recent perspectives

Applications of transcranial magnetic stimulation (TMS) in child and adolescent psychiatry

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