1-Hydroxynaphthalene-4-trifluoromethylphenyl chalcone and 3‑hydroxy-4-trifluoromethylphenyl flavone: A combined experimental, structural, in vitro AChE, BChE and in silico studies

Ghias, Mehreen; Ahmed, Muhammad Naeem; Sajjad, Bakhtawar; Rashid, Umer; Shah, Syed Wadood Ali; Shoaib, Mohammad; Madni, Murtaza; Tahir, Muhammad Nawaz; Macías, Mario A.

doi:10.1016/j.molstruc.2021.132253

Cited by 3 publications

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“…Chalcones with Hydroxy Groups on Ring A 2.1.1. Antioxidant Properties 1-Hydroxynaphthalene-4-trifluoromethylphenyl chalcone (17, Table 2) has been synthesized and tested against acetylcholinestarase (49.76 µg/mL) and butyrylcholinesterase (77.82 µg/mL) [67]. Docking studies have indicated the binding of the chalcone to the catalytic active site of acetylcholinesterase.…”

Section: Chemistry and Health Benefits Of Hydroxy Chalconesmentioning

confidence: 99%

Hydroxy Chalcones and Analogs with Chemopreventive Properties

Birsa

Sarbu

2023

IJMS

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The aim of this review is to highlight the chemopreventive properties of hydroxy-substituted natural and synthetic chalcones along with a number of their analogs. These products display various biological activities, and have many applications against various diseases. Antioxidant and anti-inflammatory properties of chalcones bearing hydroxy substituents are underlined. The influence of hydroxy substituents located on ring A, B, or both are systematized according to the exhibited biological properties.

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Section: Chemistry and Health Benefits Of Hydroxy Chalconesmentioning

confidence: 99%

Hydroxy Chalcones and Analogs with Chemopreventive Properties

Birsa

Sarbu

2023

IJMS

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“…SinteticamenteFigura 15. A: composto tacrina-4-oxo-4H-cromeno, B: composto rivastigmina-flavona, C: flavona carboxamida, D: trifluorometilfenil hidroflavona.Fonte: adaptadode Fernández-Bachiller et al, 2012, SANG et al, 2015a, Estrada-Valencia et al, 2018, Ghias et al, 2022 Por apresentar potencial no tratamento da DA, esse arcabouço vem sendo pesquisado para o planejamento de novos fármacos. Um estudo de 2012, realizado por Fernández-Bachiller e colaboradores, utilizou fragmentos de tacrina e arcabouço flavonoide, obtendo nova família de tacrina-4-oxo-4H-cromeno para o tratamento da DA (Figura 15A).…”

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