2017
DOI: 10.1016/j.scitotenv.2017.02.149
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1 H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation

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Cited by 110 publications
(58 citation statements)
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“…In this study, the BTB disruption could be a potential reason for PM 2.5 ‐caused reproductive dysfunction in male rat thus led to less sperm. Meanwhile, PM 2.5 is a complex compound composes of many endocrine‐disrupting chemical such as polycyclic aromatic hydrocarbons that influences the endocrine system at the hormone level, such as testicular testosterone by inhibiting 3 beta‐hydroxysteroid dehydrogenase (3β‐HSD) and steroidogenic acute regulatory protein (StAR) . Testosterone is curial for spermatogenesis and integrity of BTB .…”
Section: Discussionmentioning
confidence: 99%
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“…In this study, the BTB disruption could be a potential reason for PM 2.5 ‐caused reproductive dysfunction in male rat thus led to less sperm. Meanwhile, PM 2.5 is a complex compound composes of many endocrine‐disrupting chemical such as polycyclic aromatic hydrocarbons that influences the endocrine system at the hormone level, such as testicular testosterone by inhibiting 3 beta‐hydroxysteroid dehydrogenase (3β‐HSD) and steroidogenic acute regulatory protein (StAR) . Testosterone is curial for spermatogenesis and integrity of BTB .…”
Section: Discussionmentioning
confidence: 99%
“…The details of PM 2.5 extraction have been reported in previous work . A large‐volume air particle sampler (TH‐1000CII, Wuhan Tianhong, China) and quartz fiber filters (8 × 10 in, Pall) were used to collect particulate matters from April to May, 2016 in Beijing, China.…”
Section: Methodsmentioning
confidence: 99%
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“…After collection, the quartz fiber filters were cut into small pieces (5 × 5 mm 2 ), sonicated in ultrapure water for 180 minutes (30 min/time, 6 times), and then the solution was filtered using 8‐layer sterile gauze. Thereafter, the PM 2.5 powder was extracted using a vacuum freeze dryer and then was suspended in normal saline (NS) . PM 2.5 size was measured using dynamic light scattering (ZEN3690; Malvern Instruments Ltd, Malvern, UK), and the average diameter was ~300 nm.…”
Section: Methodsmentioning
confidence: 99%
“…Twelve male Sprague–Dawley rats (weight, 200 ± 20 g) were randomly divided into 2 groups ( n = 6) after acclimatization. Six rats were treated with the PM 2.5 solution (16.2 mg/kg body weight, twice a week) for 4 weeks, and the other rats treated with an equivalent volume (0.6 mL) of NS served as the control group . The PM 2.5 solution or NS was instilled into rat lungs by inserting a vein‐detained needle (14 G) into the trachea carefully through its rima glottidis after anesthetization, as shown in Figure C.…”
Section: Methodsmentioning
confidence: 99%