1-(Ethoxymethyl)-6-(Phenylselenenyl)Pyrimidines with Activity against Human Immunodeficiency Virus Types 1 and 2

Goudgaon, Ν. M.; McMillan, A; Schinazi, Raymond F.

doi:10.1177/095632029200300502

Cited by 27 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Schinazi et al [34] reported the synthesis and the biological activity of several 5-(phenylselenenyl)-pyrimidine nucleosides as potential antimicrobial agents. A variety of newly synthesized 6-phenylselenenyl acyclic pyrimidines [35,36] have recently been found to have potent antihuman immunodeficiency-virus-type-1 (HIV-1) activity. Bardos et al [37] have synthesized successfully 5-selenium-substituted derivatives of uracil, 2 0 -deoxyuridine, and 2 0 -deoxyuridylic acid.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of symmetrical bis[4-chloro-2-pyrimidyl] dichalcogenide (S, Se, Te) and unsymmetrical 4-chloro-2-(arylchalcogenyl) pyrimidine: X-ray crystal structure of 4-chloro-2-(phenylselanyl) pyrimidine and 2-(p-tolylselanyl)-4-chloropyrimidine

Bhasin

Arora

Mehta

et al. 2011

Journal of Organometallic Chemistry

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of symmetrical bis[4-chloro-2-pyrimidyl] dichalcogenide (S, Se, Te) and unsymmetrical 4-chloro-2-(arylchalcogenyl) pyrimidine: X-ray crystal structure of 4-chloro-2-(phenylselanyl) pyrimidine and 2-(p-tolylselanyl)-4-chloropyrimidine

Bhasin

Arora

Mehta

et al. 2011

Journal of Organometallic Chemistry

View full text Add to dashboard Cite

“…HEPT is a potent and selective inhibitor of HIV-1 but not HIV-2. Hence, N. M. Goudgaon et al, [28][29] synthesized selenium related analogs of HEPT (6-(phenylselenenyl) pyrimidine nucleoside analogs).…”

Section: Fig 19: Ddc Fig 20: (D4t)mentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

Pyrimidine is a 5-membered heterocyclic ring which is versatile lead compound for designing potent bioactive agents. This interesting group of compound has diverse biological activities such as antimicrobial, CNS depressant, anti-inflammatory, analgesic, anticonvulsant, anticancer, antihelmentic, antioxidant and herbicidal. Available data represents that pyrimidine being heterocyclic planar five membered ring systems has various pharmacological actions and Synthesis of various pyrimidine derivatives and their pharmacological actions discussed below. These derivatives of pyrimidine are analysed in this article for varying pharmacological activities. This review describes various Pyrimidine derivatives have potent biological and pharmacological applications.

show abstract

“…Further, 5-iodo substituted pyrimidine analogs are known for their antimicrobial[ 11 ] and antiviral activity[ 12 13 ]. Synthesis and biological activities of several compounds derived from pyrimidine analogs were reported from our laboratory[ 10 14 15 ]. We report herein the synthesis and antimicrobial activities of 4-amino-5-iodo-2-benzylthiopyrimidines (3a-g) and 4-aryl/heteroarylidenehydrazino-5-iodo-2-benzylthiopyrimidines (4a-h).…”

mentioning

confidence: 99%

Synthesis and antimicrobial evaluation of 5-iodopyrimidine analogs

2009

View full text Add to dashboard Cite

4-Substituted-5-iodo-2-benzylthiopyrimidines were prepared efficiently in three steps. 2-Benzylthiopyrimidine on iodination in presence of base gave 5-iodo-2-benzylthiopyrimidine (1), which on chlorination with excess of POCl3 furnished 4-chloro-5-iodo-2-benzylthiopyrimidine (2). Reaction of 2 with substituted aromatic amines, 2-aminopyridine and hydrazine hydrate yielded 4-amino-5-iodo-2-benzylthiopyrimidines 3(a-e), (3f) and (3g) respectively. Further, 4-hydrazino-5-iodo-2-benzylthiopyrimidine on condensation with substituted aromatic and heterocyclic aldehydes afforded the corresponding schiff bases 4(a-h). The structure of synthesized compounds have been established by spectral studies and elemental analysis. Synthesized compounds have been screened for antimicrobial activity. Compound 3f exhibited good antifungal activity against A. niger. The compounds 4a, 4c, 4d, 4g and 4h exhibited good antibacterial activity.

show abstract

1-(Ethoxymethyl)-6-(Phenylselenenyl)Pyrimidines with Activity against Human Immunodeficiency Virus Types 1 and 2

Cited by 27 publications

References 16 publications

Preparation and characterization of symmetrical bis[4-chloro-2-pyrimidyl] dichalcogenide (S, Se, Te) and unsymmetrical 4-chloro-2-(arylchalcogenyl) pyrimidine: X-ray crystal structure of 4-chloro-2-(phenylselanyl) pyrimidine and 2-(p-tolylselanyl)-4-chloropyrimidine

Preparation and characterization of symmetrical bis[4-chloro-2-pyrimidyl] dichalcogenide (S, Se, Te) and unsymmetrical 4-chloro-2-(arylchalcogenyl) pyrimidine: X-ray crystal structure of 4-chloro-2-(phenylselanyl) pyrimidine and 2-(p-tolylselanyl)-4-chloropyrimidine

Untitled

Synthesis and antimicrobial evaluation of 5-iodopyrimidine analogs

Contact Info

Product

Resources

About