1-Benzylpiperazine and other Piperazine-based Derivatives

Gee, Paul; Schep, Leo J.

doi:10.1016/b978-0-12-415816-0.00008-0

Cited by 7 publications

(2 citation statements)

References 118 publications

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“…BZP is the most studied compound [13,32,53], causing motion disorders, tremors, hypertension, urinary retention, vomiting, and paranoid psychosis related to dopaminergic activity, while anxiety, insomnia, dilated pupils, dizziness, palpitations, and chest pain are due to its adrenergic properties [13,32,54]. Cholinergic effects include vomiting, xerostomia, immunological disorders, hypersensitivity reactions, and pruritus [32,54].…”

Section: Piperazinesmentioning

confidence: 99%

An Update on the Implications of New Psychoactive Substances in Public Health

Simão

Antunes

Cabral

et al. 2022

IJERPH

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The emergence of new psychoactive substances has earned a great deal of attention, and several reports of acute poisoning and deaths have been issued involving, for instance, synthetic opiates. In recent years, there have been profound alterations in the legislation concerning consumption, marketing, and synthesis of these compounds; rapid alert systems have also been subject to changes, and new substances and new markets, mainly through the internet, have appeared. Their effects and how they originate in consumers are still mostly unknown, primarily in what concerns chronic toxicity. This review intends to provide a detailed description of these substances from the point of view of consumption, toxicokinetics, and health consequences, including case reports on intoxications in order to help researchers and public health agents working daily in this area.

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Section: Piperazinesmentioning

confidence: 99%

An Update on the Implications of New Psychoactive Substances in Public Health

Simão

Antunes

Cabral

et al. 2022

IJERPH

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“…Piperazine nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. Piperazine is a heterocyclic compound, containing nitrogen atoms at opposite positions in six membered ring [15]. The piperazine scaffold has been classified as a privileged structure and is frequently found in biologically active compounds across a number of different therapeutic areas [16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Bioactivity of Novel Tri-Heterocyclic Molecules: {4-[3-({[5-(Substituted)-1,3,4-Oxadiazol-2-Yl] SulfanyljMethyl) Benzoyl] -1 -Piperazinyl} (2-Furyl)Methanones

Abbasi¹

2018

AOICS

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In the presented investigation, some novel tri-heterocyclic benzamides, 8a-g, were synthesized in several steps. First, the electrophilic benzamide, {4-[3-(chloromethyl)benzoyl]-1-piperazinyl}(2-furyl) methanone (3), was synthesized by the reaction of 2-Furoyl-1-piperazine (1) and 3-chloromethylbenzoyl chloride (2). In second series of steps, different carboxylic acids, 4a-g, were refluxed with ethanol and conc. sulfuric acid to form esters, 5a-g. These esters were further refluxed with N 2 H 4 .H 2 O in methanol solution to acquire acid respective hydrazides, 6a-g. These hydrazides were cyclized by refluxing with KOH, ethanol and CS 2 into corresponding 1,3,4-oxadiazoles, 7a-g. In the final step, the electrophile, 3, was coupled with synthesized 1,3,4-oxadiazoles, 7a-g, in acetonitrile and potassium carbonate to acquire the targeted tri-heterocyclic molecules, 8a-g. The structural characterization of these novel compounds 8a-g was done by IR, 1 H-NMR, 13 C-NMR and EI-MS spectral data. These synthesized molecules were subjected to antibacterial and enzyme inhibitory and cytotoxicity evaluation. Among the series, 8b exhibit good enzyme inhibition whereas 8c exhibited good antibacterial and antifungal potential against B. subtilis, E. coli and A. flavus strains, respectively. Most of the molecules possessed moderate cytotoxicity and hence these can be utilized as possible therapeutic agents.

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