1-Antitrypsin deficiency * 3: Clinical manifestations and natural history

Needham, Michelle; Stockley, Robert A.

doi:10.1136/thx.2003.006510

Cited by 154 publications

(113 citation statements)

References 63 publications

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“…Finally, nearly all studies have been limited by the lack of baseline kidney biopsies. In liver transplant patients, for example, there may be pre-existing renal lesions from diabetes, hypertension, hepatitis C, and other disorders (7).…”

Section: Introductionmentioning

confidence: 99%

Tacrolimus and Cyclosporine Nephrotoxicity in Native Kidneys of Pancreas Transplant Recipients

Fioretto

Najafian

Sutherland³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Calcineurin inhibitors, while representing advances for solid organ transplantation, have nephrotoxic potential that reduces their net benefit. Tacrolimus has been considered less nephrotoxic than cyclosporine, but direct quantitative comparisons of the changes in renal structure from baseline to follow-up biopsies have not been done. To avoid the pitfalls of renal allograft studies, including rejection and disease recurrence, we compared the development of calcineurin lesions in the native kidneys of 14 tacrolimus-and 12 calcineurin-treated pancreas transplant alone recipients cured of type 1 diabetes.Design, setting, participants, & measurements Research renal biopsies obtained before and at 5 years after transplantation were studied using established morphometric methods. ResultsThe cyclosporine and tacrolimus groups had, respectively, on average, 33% versus 44% decline in GFR (ns), 27% versus 29% increase in cortical interstitial fractional volume (ns), 245% versus 347% increase in the fractional volume of cortical tubules that were atrophic (ns), and 291% versus 392% increase in the percent of globally sclerotic glomeruli (ns). Arteriolar hyalinosis did not change significantly in either group. ConclusionsThese studies indicate that the nephrotoxic potential of tacrolimus and cyclosporine are equivalent and support the development of strategies to reduce these negative effects.

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Section: Introductionmentioning

confidence: 99%

Tacrolimus and Cyclosporine Nephrotoxicity in Native Kidneys of Pancreas Transplant Recipients

Fioretto

Najafian

Sutherland³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…Так, по данным N. G. McElvaney, гомозиготами PiZZ являлись 31% паци-ентов с бронхиальной астмой [34]. В исследовании M. Needham показана высокая распространенность PIMS у пациентов с бронхиальной астмой [35]. Однако в исследовании R. M. Katz и соавт.…”

Section: Discussionunclassified

Alpha-1-Antitrypsin Deficiency in Children: Case Series

Ивановна¹,

Власов²,

Пиневская³

et al. 2016

Vopr. sovr. pediatr.

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“…Because the small portion of the intracellular A1AT that escapes polymerization and enters the circulation is also defective in its ability to inhibit elastase, Z homozygotes usually present with more severe pulmonary disease (16 ). In addition, the accumulation of polymerized A1AT protein in the hepatocytes leads to liver disease, which can progress to cirrhosis (17 ).…”

mentioning

confidence: 99%

Diagnosis of α-1-Antitrypsin Deficiency: An Algorithm of Quantification, Genotyping, and Phenotyping

Snyder¹,

Katzmann²,

Butz

et al. 2006

Clinical Chemistry

107

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Background: Laboratory testing in suspected ␣-1-antitrypsin (A1AT) deficiency involves analysis of A1AT concentrations and identification of specific alleles by genotyping or phenotyping. The purpose of this study was to define and evaluate a strategy that provides reliable laboratory evaluation of A1AT deficiency. Methods: Samples from 512 individuals referred for A1AT phenotype analysis were analyzed by quantification, phenotype, and genotype. A1AT concentrations were measured by nephelometry. Phenotype analysis was performed by isoelectric focusing electrophoresis. The genotype assay detected the S and Z deficiency alleles by a melting curve analysis. Results: Of the 512 samples analyzed, 2% of the phenotype and genotype results were discordant. Among these 10 discordant results, 7 were attributed to phenotyping errors. On the basis of these data we formulated an algorithm, according to which we analyzed samples by genotyping and quantification assays, with a reflex to phenotyping when the genotype and quantification results were not concordant. Retrospective analyses demonstrated that 4% of samples submitted for genotype and quantitative analysis were reflexed to phenotyping. Of the reflexed samples, phenotyping confirmed the genotype result in 85% of cases. In the remaining 15%, phenotyping provided further information, including identifying rare deficiency alleles and suggesting

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1-Antitrypsin deficiency * 3: Clinical manifestations and natural history

Cited by 154 publications

References 63 publications

Tacrolimus and Cyclosporine Nephrotoxicity in Native Kidneys of Pancreas Transplant Recipients

Tacrolimus and Cyclosporine Nephrotoxicity in Native Kidneys of Pancreas Transplant Recipients

Alpha-1-Antitrypsin Deficiency in Children: Case Series

Diagnosis of α-1-Antitrypsin Deficiency: An Algorithm of Quantification, Genotyping, and Phenotyping

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