1,927-nm Fractional Thulium Fiber Laser for the Treatment of Nonfacial Photodamage: A Pilot Study

Polder, Kristel D.; Harrison, A.; Eubanks, Leigh Ellen; Bruce, Suzanne

doi:10.1111/j.1524-4725.2011.01884.x

Cited by 40 publications

(48 citation statements)

References 10 publications

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“…We applied 70 mJ/spot of NAFL energy in this preclinical experiment based on previous reports [28]. This is a dose higher than that used clinically (5-20 mJ/spot) [29,30]. However, because of the characteristics of NAFL, it was still confined within the dermis layer and caused molecular changes.…”

Section: Discussionmentioning

confidence: 99%

Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

Yoo

Park

et al. 2017

Current Optics and Photonics

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In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.

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Section: Discussionmentioning

confidence: 99%

Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

Yoo

Park

et al. 2017

Current Optics and Photonics

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“…This laser class safely and effectively treats epidermal pigmentation, photoaging, melasma, rhytides, atrophic, surgical, and acne-related scarring and additional textural imperfections. [34][35][36][37][38] As with other lasers, the laser targets water in the dermis, gently heating it to cause controlled thermal tissue damage. The fractionated component of the laser allows for a spatially precise, regular pattern of columns of tissue injury to be created across the treated region, retaining the healing function of the epidermis even while targeting both skin layers.…”

Section: Nd:yag Laser (Cynosure Affirm and Palomar Starlux)mentioning

confidence: 99%

Current Laser Resurfacing Technologies: A Review that Delves Beneath the Surface

Preissig

Hamilton

Markus

2012

Seminars in Plastic Surgery

134

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).Laser resurfacing technologies represent an exciting development in the cosmetic surgeon's repertoire to improve the tone, texture, and pigmentation of the skin. Although laser resurfacing is not a substitute for a facelift or blepharoplasty, the appropriate laser not only tightens the skin somewhat but also improves the appearance of lentigines, rhytides, skin texture, and a wide variety of scars.There are ablative and nonablative lasers as well as fractionated and nonfractionated lasers. Nonfractionated lasers act on the entire projected surface area of the treated skin, whereas fractionated lasers target an equally distributed portion of the projected area. An easy way to understand the difference is in looking at the pixels that compose a TV image. Nonfractionated devices treat every single pixel whereas fractionated devices treat only a percentage of the pixels in the treatment area.Ablative lasers vaporize tissue and therefore are more aggressive compared with the gentler nonablative lasers that leave the skin intact. Although ablative lasers result in far more down time and a more difficult recovery process, they remain the lasers that produce the most dramatic outcomes. For more severe facial wrinkles, dyspigmentation, and textural skin challenges, the ablative laser is often the treatment of choice.For patients seeking more moderate improvement-without the possible side effects of ablative lasers-nonablative lasers are often ideal. These lasers leave the epidermis intact while producing rejuvenating skin effects. Depending on the technology, nonablative laser treatments may minimize the appearances of finer wrinkles, ameliorate the texture and tone of the skin, and treat dyspigmentation. By comparison, the treatments are gentler and require little to no downtime, but produce a more moderate response.Ultimately, a patient's needs dictate the selection of the ideal laser. In this review, we seek to demystify the differences between the many available lasers and thereby facilitate the identification of the most appropriate laser for the patient. Ablative Nonfractionated LasersAblative skin resurfacing removes the epidermal layer, producing the most dramatic laser-treated results for skin resurfacing. The lasers quickly superheat water molecules in the skin tissue. When the water turns into gas, the skin cells are vaporized in a precise skin-peeling effect. This effect promotes collagen formation and retraction of the dermis and AbstractNumerous laser platforms exist that rejuvenate the skin by resurfacing its upper layers. In varying degrees, these lasers improve the appearance of lentigines and rhytides, eliminate photoaging, soften scarring due to acne and other causes, and treat dyspigmentation. Five major classes of dermatologic lasers are currently in common use: ablative and nonablative lasers in both fractionated and unfractionated forms as well as radiofrequency technologies. The gentler nonablative lasers allow for quicker healing, whereas harsher ablative lasers tend to be more effective. Fract...

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“…This leads to an increased ability to target the epidermis and treat more superficial processes, such as dyspigmentation. 62 After 2 treatments with the 1927-nm thulium laser, 82% of patients achieved a moderate to significant improvement in photopigmentation at 1 month after treatment. 63 There was also appreciable improvement, albeit to a lesser degree, in both fine and coarse wrinkling.…”

Section: Skin Rejuvenation and Tighteningmentioning

confidence: 95%

“…63 There was also appreciable improvement, albeit to a lesser degree, in both fine and coarse wrinkling. 62 In addition, there is a report of successful treatment of macular seborrheic keratoses with the 1927-nm NAFL. 64 While the improvement in pigmentation, fine rhytides, and overall texture is well established with NAFLs, there has been some controversy over whether the NAFLs truly have a skin-tightening effect, despite several studies reporting this benefit.…”

Section: Skin Rejuvenation and Tighteningmentioning

confidence: 99%

“…65 While caution is still needed due to increased risks of side effects, there have been multiple studies showing the safety and efficacy of NAFLs on the neck, chest, arms, and hands. 62,[67][68][69][70] As with the AFLs, the growing interest in vaginal rejuvenation has also led to the use of NAFLs for this purpose. The newer nonablative 2940-nm Er:YAG laser, delivered through a collimated patterned handpiece, has been shown to improve vaginal laxity by inducing neocollagenesis.…”

Section: Skin Rejuvenation and Tighteningmentioning

confidence: 99%

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Advances in fractional technology for skin rejuvenation, skin tightening, drug delivery, and treating scars and skin defects

2017

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I n recent decades, there has been a revolution in energy-based treatment options for skin scarring, rejuvenation, and tightening. One of the most promising developments has been the introduction of fractional photothermolysis, developed by Anderson and Manstein in 2004. Fractionated systems deliver laser energy in a grid-like pattern, creating microscopic columns of ablative and/or coagulative damage termed microthermal zones (MTZs), which stimulate collagen remodeling.1 The incorporation of fractional photothermolysis into energy-based devices has allowed less destruction to surrounding tissue, leading to desired results with the minimization of unwanted side effects, leading to both ablative and nonablative laser devices becoming desirable treatment options for cutaneous scarring and rejuvenation. Given their impressive results, newer fractional laser treatment options, including picosecond lasers, quality-switched (QS) lasers, and combined ablative and nonablative lasers, are being investigated for the treatment of these common skin conditions.The following review addresses the current and emerging topics on fractional laser treatment of skin scarring and rejuvenation based on the device type, including ablative, nonablative, QS, picosecond, and hybrid fractional lasers (HFLs). Additionally, newer energy-based fractional devices, such as radiofrequency (RF) with and without microneedling and the use of fractionated technology for drug delivery, are discussed in the context of these common skin conditions. Fractionated lasersTreatment options for cutaneous scars and skin rejuvenation have evolved significantly since the rise in popularity of ablative lasers in the 1990s. Newer treatment options, including ablative fractional lasers (AFL) and nonablative fractional lasers (NAFL), have garnered favor, given the milder side effect profile in comparison with traditional fully ablative lasers. Ablative fractional lasersAcne scarring AFLs were developed in an attempt to achieve the efficacy of traditional ablative lasers with the milder side effect profile of fractional technology. Although a single treatment produces less dramatic, albeit noticeable, results than traditional fully ablative lasers can, multiple treatments result in greater clinical improvement.2 Currently, there are 3 types of AFLs available for scar treatment: the 10600-nm carbon dioxide (CO2), the 2940-nm erbium:yttrium aluminum garnet (Er:YAG), and the 2740-nm yttrium scandium gallium garnet (YSGG) lasers. AFL is associated with the increased risk of both protracted erythema and postinflammatory hyperpigmentation (PIH) in darker skin types, which has led many clinicians to prefer a longer series of NAFL treatments over AFL treatments to achieve similar results with a lower risk of side effects.Multiple studies support the efficacy of the fractional CO2 laser in acne scars. The overwhelming majority of these studies investigate the utility of these lasers in atrophic facial scars. While NAFLs typically require multiple sessions to achieve modest ...

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1,927-nm Fractional Thulium Fiber Laser for the Treatment of Nonfacial Photodamage: A Pilot Study

Abstract: The 1,927-nm fractional thulium fiber laser is a safe, effective treatment for nonfacial photodamage. Dr. Polder is a principal investigator and Dr. Suzanne Bruce is a consultant for Solta Medical.

Cited by 40 publications

References 10 publications

Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

Current Laser Resurfacing Technologies: A Review that Delves Beneath the Surface

Advances in fractional technology for skin rejuvenation, skin tightening, drug delivery, and treating scars and skin defects

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