1,8-Dihydroxy-3-methyl-6-(oxiran-2-ylmethoxy)-9,10-dihydroanthracene-9,10-dione

Abstract

Key indicatorsSingle-crystal X-ray study T = 296 K Mean (C-C) = 0.003 Å R factor = 0.052 wR factor = 0.169 Data-to-parameter ratio = 15.4For details of how these key indicators were automatically derived from the article, see

6-[3-(2,4-Dimethylanilino)-2-hydroxypropoxy]-1,8-dihydroxy-3-methyl-9,10-dihydroanthracene-9,10-dione

“…Emodin and its derivatives have been found to possess diverse biological properties, such as antimicrobial, antiviral, antitumor, anti-inflammatory, anti-oxidant, immunosuppressive, anti-ulcerogenic, fungicidal and chemopreventive activities (Wang & Xu, 2005;Teich et al, 2004;Srinivas et al, 2003). As part of our ongoing research on emodin derivatives (Wang & Xu, 2005;Wang et al, 2006), we report here the crystal structure of the title compound.…”

“…The organic phase was washed with water (15 ml) and brine (15 ml), and dried over anhydrous sodium sulfate. The solvent was removed to give the key intermediate, 1,8-Dihydroxy-3-methyl-6-(oxiran-2-ylmethoxy)-9,10-dihydroanthracene-9,10-dione (Wang et al, 2006) as a yellow oil, which was purified by flash chromatography (silica gel, petroleum ether-acetone 3:1). To a solution of above intermediate (0.326 g, 1 mmol) in chloroform was added 2,4-dimethylaniline (1.1 mmol).…”