1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

Hoch, Cosima C.; Petry, Julie; Griesbaum, Lena; Weiser, Tobias; Werner, Kathrin; Ploch, Michael; Verschoor, Admar; Multhoff, Gabriele; Bashiri Dezfouli, Ali; Wollenberg, Barbara

doi:10.1016/j.biopha.2023.115467

Cited by 15 publications

(4 citation statements)

References 160 publications

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“…Limonene is a monocyclic monoterpene that may be extracted abundantly from citrus peel waste or obtained via microbial biosynthesis [ 57 , 58 ]; this compounds and its derivatives are present as common additives in several markets, such as cosmetics, food, pharmaceuticals, cosmetics, and biobased polymers [ 57 , 59 , 60 ]. 1,8-cineole (eucalyptol) is another of the most investigated compounds in recent years, and various pieces of evidence point to its potential as a phytochemical treatment for respiratory disorders, such as chronic obstructive pulmonary disease (COPD), due to its mucolytic, anti-inflammatory, antimicrobial, bronchodilator, and antioxidant activities [ 61 , 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemistry, Bioactivity, and Ethnopharmacology of the Genus Lepechinia Willd. (Lamiaceae): A Review

Ramírez,

Gilardoni,

Radice

et al. 2024

Plants

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The genus Lepechinia (Lamiaceae) involves several aromatic shrubs that are distributed only in the American continent, inhabiting mountain areas, mainly in the Andean region of South America. Based on the PRISMA approach, we selected and critically analyzed 48 research articles. From a phytochemical point of view, most of the secondary metabolites reported in Lepechinia spp. are terpenes and terpenoids, with a few exceptions comprising flavonoids and other shikimic acid derivatives. On the one hand, sesquiterpenoids of the guajane, aromadendrane, eudesmane, and cadinane groups are characteristic of essential oils, together with (E)-β-caryophyllene as the main representative of its chemical family. On the other hand, abietane diterpenoids are the prevalent compounds described in non-volatile fractions. Many biological activities and traditional medical uses have been reported for both pure metabolites and complex mixtures (e.g., essential oils). Regarding ethno-medical uses, the treatment of muscle pain, headache, toothache, diabetes mellitus, uterine tumors, uterine infections, and diarrhea has been reported. Concerning their verified biological activities, insecticidal, antifungal, antioxidant, and anticholinesterase properties have been described. Furthermore, some data concerning anti-herpetic activity have been reported.

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Section: Resultsmentioning

confidence: 99%

Phytochemistry, Bioactivity, and Ethnopharmacology of the Genus Lepechinia Willd. (Lamiaceae): A Review

Ramírez,

Gilardoni,

Radice

et al. 2024

Plants

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“…An irregular growth of cells or tissues in body is called cancer ( 52 ). There is significant global interest in research on cancer prevention, and it is claimed that adopting a healthy lifestyle and using natural agents can help prevent certain types of cancer.…”

Section: Resultsmentioning

confidence: 99%

Production of natural flavor compounds using Bacillus subtilis-fermented soybean meal extract and their biological potential: a comprehensive in vitro study

Abd-Alrahman,

Ramadan,

Maraay

et al. 2024

Front. Nutr.

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This study aims to investigate the production of natural flavor compounds through the utilization of Bacillus subtilis-fermented soybean meal extract and evaluate their biological potential. The experiment involved a comprehensive in vitro investigation to assess the capabilities and effects of the produced flavor compounds. The resulting flavor compounds were subjected to various in vitro tests to assess their properties, including cytotoxicity, antioxidant activity, anticancer potential, antiviral activity, and antimicrobial activity. To enhance the fermentation process, soybean meal extract was fortified with a combination of L-Lysine and L-Threonine. Gas chromatography-mass spectrometry (GC/MS) analysis was conducted on the fermented soybean meal using two strains of Bacillus subtilis, namely NRCH123 and NRCZ144. This analysis revealed the presence of various volatile compounds in all extracts, including Butylated hydroxytoluene. The fermented soybean extract with bacillus subtilis NRCZ144 (B2) fortified with a combination of 2.5% (w/w) L-Lysine and 2.5% w/w L-threonine (SLT2) exhibited a rich profile of flavor compounds, with Eucalyptol being identified as the predominant compound. The antioxidant activity of the SLT2 extract was found to be 72.04% at a concentration of 100 μg/mL, indicating significant antioxidant potential. Furthermore, when tested against the human liver cancer cell line HepG2, the extract demonstrated anticancer activity with an IC50 value of 2.26 μg/mL. The extract exhibited potent cytotoxicity, with an IC50 value of 1.02 μg/mL. Importantly, the SLT2 extract displayed strong antibacterial and antifungal activity, even at very low concentrations. The extract’s antimicrobial properties indicate its potential for inhibiting the growth of bacteria and fungi.

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“…Di et al (2022) noted that dietary supplementation of 1,8-cineole at 10 to 40 mg/kg improves the growth performance of broilers by strengthening antioxidant 12 capacity, immunity and intestinal morphology. It should be highlighted that 1,8-cineole, a major compound in rosemary, exhibits a range of biological properties, including anti-inflammatory, antioxidant, antimicrobial, bronchodilatory, analgesic and pro-apoptotic (Hoch et al, 2023). The authors have highlighted the benefits of this molecule for human health, as demonstrated in clinical trials involving patients suffering from respiratory disorders, including chronic obstructive pulmonary disease, asthma, bronchitis, and rhinosinusitis.…”

Section: Discussion Discussion Discussionmentioning

confidence: 99%

Effect of powdered rosemary (Rosmarinus officinalis) essential oil and phenolic compounds on broiler chickens zootechnical parameters

FILALI SAMOUH,

ZINEDINE,

ROCHA

et al. 2024

Not Sci Biol

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This work aims at exploiting the essential oil (EO) and phenolic compounds (PC) of rosemary (Rosmarinus officinalis) in a formulation containing leaf powder stabilized with chitin (1%, w/w) to improve chicken meat and investigate their effect on qualitatively and quantitatively broiler chickens’ growth performances. To such a purpose, chicks, at 1 day of age, were distributed in pens on ground divided into four batches. The two control batches were fed with conventional feed, but the positive control contained flavomycin (0.5 g/kg) as growth factor. The two treated batches received a conventional feed supplemented with two doses of 20 and 50 g/kg of the developed formulation. Essential oil and phenolic compound contents in powdered leaves were, respectively, 1.20 and 22.86% in ethanolic extract. 1,8-Cineole (46.88%), followed by camphor (19.20%), α-pinene (9.56%), L.α.-terpineol (5.91%) and β-pinene (4.40%) were the main compounds of the used EO. The two batches of treated chicks showed a significant improvement in body weight (281.88 and 283.75 g, respectively), a decrease in feed conversion and a reduction in mortality (8%), when compared to the control batches. In addition, the elaborated formulation induced catalase activity used as an indicator of cellular antioxidant activity modulation.

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1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

Cited by 15 publications

References 160 publications

Phytochemistry, Bioactivity, and Ethnopharmacology of the Genus Lepechinia Willd. (Lamiaceae): A Review

Phytochemistry, Bioactivity, and Ethnopharmacology of the Genus Lepechinia Willd. (Lamiaceae): A Review

Production of natural flavor compounds using Bacillus subtilis-fermented soybean meal extract and their biological potential: a comprehensive in vitro study

Effect of powdered rosemary (Rosmarinus officinalis) essential oil and phenolic compounds on broiler chickens zootechnical parameters

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