1,5-Anhydroglucitol (1,5-Ag) and its Usefulness in Clinical Practice

Dąbrowska, Anna; Tarach, Jerzy S.; Kurowska, Maria

doi:10.2478/v10251-012-0049-z

Cited by 7 publications

(19 citation statements)

References 24 publications

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“…On the other hand, the TwinUK cohort study also observed a negative association between dairy intake and 1,5‐AS, which unfortunately was not replicated in other cohorts . However, 1,5‐AS is present in some food products, mainly soy, albeit the effect of diet alone on serum levels seems limited . Further, myo‐inositol levels were decreased after the HD intervention.…”

Section: Discussionmentioning

confidence: 93%

Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes

O’Connor

Leclercq

Julien

et al. 2019

Molecular Nutrition Food Res

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Scope Metabolomics is increasingly used to identify biomarkers of diet or chronic diseases, such as type 2 diabetes. Yet, metabolite signatures following dairy intake in hyperinsulinemic subjects have not been identified. The objective is to evaluate the effects of a high dairy diet (HD) for 6 weeks (4 servings or more per day), compared with an adequate dairy diet (AD) (2 servings or less per day), on serum metabolite profiles in hyperinsulinemic adults. Methods and results In this crossover trial, subjects are randomized to HD or AD for 6 weeks. Serum metabolites are assessed using GC/MS. Twenty‐six subjects completed the study. Levels of pentadecanoic acid, tyrosine and lathosterol are increased in HD, while 1,5‐anhydrosorbitol, myo‐inositol, 3‐aminoisobutyric acid and beta‐sitosterol are decreased (p < 0.05). Sorbitol levels are increased after AD, while hexanoic acid, lauric acid, l‐kynurenine, methionine, and benzoic acid levels are reduced (p < 0.05). Histidine, caprylic acid, nonanoic acid, decanoic acid, lauric acid, heptadecanoic acid, and benzoic acid levels are increased in HD compared to AD, while malic acid levels are increased in AD compared with HD (p < 0.05). Conclusion Higher dairy products intake modifies metabolite profiles in hyperinsulinemic subjects.

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Section: Discussionmentioning

confidence: 93%

Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes

O’Connor

Leclercq

Julien

et al. 2019

Molecular Nutrition Food Res

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“…Another method for the determination of 1,5-AG is chromatography, specifically gas chromatography-mass spectrometry (GC/MS) and high-performance liquid chromatography (HPLC). These methods are sensitive and precise but require sample preparation and are time-consuming and cumbersome[99]. Urine, a sample with lower 1,5-AG levels, requires a more sensitive method such as liquid chromatography/mass spectrometry (LC/MS) or HPLC[100].…”

Section: 5-anhydroglucitolmentioning

confidence: 99%

Update on biomarkers of glycemic control

Krhač¹,

Lovrenčić²

2019

WJD

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Attaining and maintaining good glycemic control is a cornerstone of diabetes care. The monitoring of glycemic control is currently based on the self-monitoring of blood glucose (SMBG) and laboratory testing for hemoglobin A1c (HbA1c), which is a surrogate biochemical marker of the average glycemia level over the previous 2-3 mo period. Although hyperglycemia is a key biochemical feature of diabetes, both the level of and exposure to high glucose, as well as glycemic variability, contribute to the pathogenesis of diabetic complications and follow different patterns in type 1 and type 2 diabetes. HbA1c provides a valuable, standardized and evidence-based parameter that is relevant for clinical decision making, but several biological and analytical confounders limit its accuracy in reflecting true glycemia. It has become apparent in recent years that other glycated proteins such as fructosamine, glycated albumin, and the nutritional monosaccharide 1,5-anhydroglucitol, as well as integrated measures from direct glucose testing by an SMBG/continuous glucose monitoring system, may provide valuable complementary data, particularly in circumstances when HbA1c results may be unreliable or are insufficient to assess the risk of adverse outcomes. Long-term associations of these alternative biomarkers of glycemia with the risk of complications need to be investigated in order to provide clinically relevant cut-off values and to validate their utility in diverse populations of diabetes patients.

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“…There is virtually no metabolism of 1,5-AG in the body; instead, it is extracted by the kidneys where it is 99.9% reabsorbed via the SGLT-4 sodium-glucose transporter. Only after exceeding the so called renal threshold for glucose (approximately 180 mg/dL), glucose competitively suppresses 1,5-AG reuptake, which results in reduced serum concentration and loss with urine [32]. As a result of our research, we showed that mean 1,5-AG levels in all biological materials (blood, serum, VH) were significantly lower in the study group (of diabetics) compared to the control group.…”

Section: Discussionmentioning

confidence: 49%

“…It belongs to the group of polyols, so called polyhydric alcohols derived from sugars (containing more than two hydroxyl groups) [31]. In recent years, determination of 1,5-AG concentration as a marker of postprandial hyperglycemia during pregnancy or before surgeries has been growing in popularity [32]. The primary source of 1,5-AG is food.…”

Section: Discussionmentioning

confidence: 99%

Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions

Nowak

Zawadzki

2020

Diagnostics

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Diabetes mellitus is classified as the epidemic of the 21st century. Due to the fact that acute carbohydrate metabolism disorders usually do not indicate morphological change, postmortem diagnosis is required to perform biochemical tests. The authors decided to evaluate the usefulness of determining glucose, lactate, acetone, β-hydroxybutyric acid (BHB), and 1,5-anhydroglucitol (1,5-AG) in postmortem blood/serum, urine, and vitreous humor (VH). Biological material was collected during autopsies. The study group consisted of 50 diabetics, while the control group consisted of 50 non-diabetics, who died a sudden death, with negative test results for the presence of ethyl alcohol and were not resuscitated before death. Statistical analysis was performed using the IBM SPSS Statistics 25 software package. The most statistically significant difference between the two groups was observed for mean 1,5-AG concentration. The authors found many correlations between the concentration of the examined markers in different materials, mainly between blood/serum and VH. The most suitable short-term glycemic marker in postmortem diagnosis is 1,5-AG. Diagnosis may be supported with determinations of acetone and BHB. For medicolegal assessment, the interpretation of the biochemical test results should comprise information on circumstances of death, medical history, results of other toxicological and histopathological tests, and autopsy report.

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1,5-Anhydroglucitol (1,5-Ag) and its Usefulness in Clinical Practice

Cited by 7 publications

References 24 publications

Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes

Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes

Update on biomarkers of glycemic control

Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions

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