1,5,7-Triazabicyclo[4.4.0]dec-1-ene (TBD), 7-methyl-TBD (MTBD) and the polymer-supported TBD (P-TBD): three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems

Application of Heterogeneous Catalysts in the First Steps of the Oseltamivir Synthesis

“…Three heterogeneous basic catalysts were tested ( Figure 2): Amberlite IRA-400 [31] (quaternary ammonium hydroxide) and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), supported on either polystyrene (TBD-PS [32]) or silica (TBD-SiO2 [33]). Their activities were compared with tetramethylammonium hydroxide and TBD, which are the homogeneous counterparts.…”

Nanostructured Catalysts for the Aldol, Knoevenagel, and Henry Reactions

“…For example, by immobilizing bicyclic guanidine bases such as 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) and its methyl derivative into polymeric systems, Simoni et al synthesized polymersupported efficient solid-base heterogeneous catalysts for the Henry reaction as well as the addition reaction between dialkyl phosphites to unsaturated compounds. 84 The catalytic reactions involving these polymer-supported catalysts are particularly interesting because the synthesis of the catalysts involve simple procedures and the reaction could be carried out without the need for acidification, which is known to lead to side reactions.…”

Polymer‐Supported Organosuperbases

“…For example, PS-TBD has been shown to be an efficient promoter to realize the addition reaction of nitroalkanes to aldehydes and alicyclic ketones, that is, the Henry reaction [31] (Scheme 6.3). This method is of great value in terms of its simplicity for purification as well as mild reaction conditions and fast reactions.…”