1,4-Benzodiazepines and their cyclic homologs and analogs

Bogatskii, A. V.; Rudenko, O. P.; Андронати, С. А.; Chumachenko, T. K.

doi:10.1007/bf00471854

Cited by 3 publications

(2 citation statements)

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“…At the same but not for the first time, Chastrette and Gauthier reported that the direct synthesis is accompanied by substantial amounts of the coupling product R−R. Bogat‐skii et al . verified that the direct synthesis proceeds much more efficiently in ethereal solvents than in hydrocarbons.…”

Section: Homologous Grignard‐type Chemistrymentioning

confidence: 99%

Heavy Grignard Reagents: Synthesis, Physical and Structural Properties, Chemical Behavior, and Reactivity

Westerhausen

Koch

Görls

et al. 2016

Chemistry A European J

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The Grignard reaction offers a straight forward atom-economic synthesis of organomagnesium halides, which undergo redistribution reactions (Schlenk equilibrium) yielding diorganylmagnesium and magnesium dihalides. The homologous organocalcium complexes (heavy Grignard reagents) gained interest only quite recently owing to several reasons. The discrepancy between the inertness of this heavy alkaline earth metal and the enormous reactivity of its organometallics hampered a vast and timely development after the first investigation more than 100 years ago. In this overview the synthesis of organocalcium reagents is described as is the durability in ethereal solvents. Aryl-, alkenyl-, and alkylcalcium halides are prepared by direct synthesis. Characteristic structural features and NMR parameters are discussed. Ligand redistribution reactions can be performed by addition of potassium tert-butanolate to ethereal solutions of arylcalcium iodides yielding soluble diarylcalcium, whereas sparingly soluble potassium iodide and calcium bis(tert-butanolate) precipitate. Furthermore, reactivity studies with respect to metalation and addition to unsaturated organic compounds and metal-based Lewis acids, leading to the formation of heterobimetallic complexes, are presented.

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Section: Homologous Grignard‐type Chemistrymentioning

confidence: 99%

Heavy Grignard Reagents: Synthesis, Physical and Structural Properties, Chemical Behavior, and Reactivity

Westerhausen

Koch

Görls

et al. 2016

Chemistry A European J

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“…In a similar way, compounds XIV and XVII were synthesized with MeONa and t-BuOK as bases. -2-(3-chloropropanoylamino)benzophenone (XX) was prepared from compound XIX according to [16]. 922 ANDRONATI et al…”

Section: -Bromo-2-(propenoylamino)benzophenone Syn-oxime (Xii)mentioning

confidence: 99%

Reaction of 5-Substituted 2-(3-Chloropropanoylamino)benzophenone syn- and anti-Oximes with Sodium Hydroxide

et al. 2005

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Treatment of syn-oximes of 5-substituted 2-(3-chloropropanoylamino)benzophenones with equimolar amount of sodium hydroxide results in formation of syn-oximes of 5-substituted 2-propenoylaminobenzophenones. The corresponding anti isomers under the same conditions give a mixture of anti-oximes of 5-substituted 2-(propenoylamino)benzophenones and 18-membered 11,22-disubstituted 7,8,18,19-tetrahydrodibenzo[d,m][1,10,2,6,11,15]dioxatetraazacyclooctadecine-6,17(5H,16H)-diones.

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1992

Chemistry of Heterocyclic Compounds: A Series of Monographs

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1,4-Benzodiazepines and their cyclic homologs and analogs

Cited by 3 publications

References 2 publications

Heavy Grignard Reagents: Synthesis, Physical and Structural Properties, Chemical Behavior, and Reactivity

Heavy Grignard Reagents: Synthesis, Physical and Structural Properties, Chemical Behavior, and Reactivity

Reaction of 5-Substituted 2-(3-Chloropropanoylamino)benzophenone syn- and anti-Oximes with Sodium Hydroxide

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