1, 4-Addition of Terminal Alkynes to Conjugated Enones in Water Using Green Catalyst Bis[(l)prolinato-N,O]Zn—An Environmentally Benign Protocol

Abstract

An easy, low cost, and green procedure is proposed for the 1, 4-addition of terminal alkynes to conjugated enones in water as a sole medium using easily accessible Zn[(L)Proline] 2 . This protocol has advantages of high yield, mild reaction conditions, no environmental pollution and simple work up procedure.

Bis[( l )prolinate-N,O]Zn: A water-soluble and recycle catalyst for various organic transformations

“…Kidwai and his co-workers (2011) had acquired various images of complex on carbon coated grid and confirmed the crystalline in nature of the complex as depicted in Fig. 5 [37] .…”

“…The recyclability of complex depends upon its solubility in the reaction medium. Majority of the reactions with complex are performed in aqueous medium and extracted with organic solvent (Ethyl acetate, ether, chloroform or DCM) from the aqueous layer and reused for further reaction [29] , [36] , [37] . In aqueous medium the reactivity of metal complexes is restricted because water molecules can participate as substrate for metal bonding.…”

Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives

“…Zn(L-proline)2 was prepared following the literature procedure [27,28]. Other chemicals were purchased from Sigma Aldrich and were used as such.…”

Zn[(L)Proline]2: an eligible candidate for the synthesis of xanthenediones in water

“…As a part of our ongoing research program aimed at developing ecofriendly methods for carrying out various organic transformations, we report herein the recently explored Zn[(L)Proline] 2 complex as an efficient catalyst for the synthesis of xanthenediones.…”

“…The design and synthesis of organometallic complexes have recently been the subject of intense interest, [31] not only because of their fascinating structural topology but also their potential applications as functional materials in magnetism, molecular absorption, fluorescence, catalysis and chemical separation. [32,33] As a part of our ongoing research program aimed at developing ecofriendly methods for carrying out various organic transformations, [34][35][36] we report herein the recently explored Zn[(L)Proline] 2 complex as an efficient catalyst for the synthesis of xanthenediones.…”