1,4,7-Triazacyclononane-1-succinic acid-4,7-diacetic acid (NODASA): a new bifunctional chelator for radio gallium-labelling of biomolecules

High Relaxivity for Monomeric Gd(DOTA)-Based MRI Contrast Agents, Thanks to Micellar Self-Organization

“…We have previously demonstrated the feasibility of this approach in the field of Ga-radiopharmaceuticals. [21] Now we have extended the method of ªprotection by the metalº to Gd III complexes by coupling N-methyldodecylamine to [Gd(DOTASA)] 2À . A similar synthetic approach has been recently applied to prepare the phenanthridyl derivative of a monoamide-triphosphinate-cyclen ligand.…”

Unexpected Sensitivity of sst2 Antagonists to N-Terminal Radiometal Modifications

“…We do not have a full explanation for the strong influence of the choice of radiometal. We explained the metal iondependent differences in the case of the agonists with differences in the coordination sphere as revealed by x-ray crystal structures of the model peptides Y-DOTA-D-Phe-NH 2 , Ga-DOTA-D-Phe-NH 2 and Ga(NODASA) (21,22). X-ray structures are given in the supplemental information (supplemental materials are available online only at http:// jnm.snmjournals.org).…”

Development of 68Ga-labeled multivalent nitroimidazole derivatives for hypoxia imaging

“…to avoid this problem [36,[49][50][51][52]. (1), NOTGA (contains glutaric acids), (2) and TRAP (contains phosphinic acids) (3).…”