(1–3)-β-D-glucan levels in candidiasis infections in the critically ill neonate

Goudjil, Sabrina; Kongolo, G.; Dusol, Lucie; Imestouren, Fatiha; Cornu, Marjorie; Léké, A.; Chouaki, Taïeb

doi:10.3109/14767058.2012.722716

Cited by 51 publications

(40 citation statements)

References 28 publications

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“…Among 18 infants who were diagnosed with invasive candidiasis, the mean 1-3-β-D-glucan level was 364 pg/mL (range 131–976) compared with 89 pg/mL (range 30–127) among non-infected control infants. 87 However, healthy children and infants have higher 1-3-β-D-glucan levels than adults, suggesting that age-specific cutoffs may be necessary, and larger prospective studies are needed before use of 1-3-β-D-glucan assays can be recommended for the diagnosis of neonatal candidiasis. 90, 91 …”

Section: Diagnosismentioning

confidence: 99%

The Epidemiology and Diagnosis of Invasive Candidiasis Among Premature Infants

Kelly

Benjamin

Smith

2015

Clinics in Perinatology

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Invasive candidiasis is a leading infectious cause of morbidity and mortality in premature infants. Improved recognition of modifiable risk factors and antifungal prophylaxis have contributed to the recent decline in the incidence of this infection among infants. Invasive candidiasis typically occurs in the first six weeks of life and presents with non-specific signs of sepsis. Definitive diagnosis relies on growth of Candida in blood culture or cultures from other normally sterile sites, but this may identify fewer than half of cases. Improved diagnostics are needed to guide initiation of antifungal therapy in premature infants.

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Section: Diagnosismentioning

confidence: 99%

The Epidemiology and Diagnosis of Invasive Candidiasis Among Premature Infants

Kelly

Benjamin

Smith

2015

Clinics in Perinatology

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“…Preterm infants are predisposed to Candida infections because of immaturity of their immune system and invasive interventions. 5,6 Transmission of Candida may be vertical (from maternal vaginal infection) or nosocomial. Colonization of health workers is as high as 30%.…”

Section: Introductionmentioning

confidence: 99%

Clinical profile of neonatal candidiasis in newborn nursery

James

Anuja

Ninan

2018

Int J Contemp Pediatr

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Background: Candidiasis refers to infection with fungi of the genus candida. Candida infections are frequent and major causes of septicemia in neonatal intensive care units and are associated with high morbidity and mortality. Low birth weight preterm infants are especially vulnerable to these devastating infections. Candida infections are a major cause of septicemia in neonatal ICUs and may affect 1.6% to 12.9% of very low birth weight infants. The smaller the infant is, the greater is the likelihood for systemic fungal infection to develop.Methods: 40 Newborns with culture proven candidiasis admitted in new-born nursery of Government T. D Medical College, Alappuzha, were selected for the study. The significance of different parameters such as gender, gestational age, birth weight, Apgar score, duration of hospital stays, central venous catheter and use of third generation cephalosporins were analysed. Clinical profile like apnoea, feed intolerance, requirement of ventilator support, temperature instability, thrombocytopenia, hyperglycemia etc. were analyzed.Results: Out of 40 newborns 39 were preterms, 42% of study population were having a birth weight of 1-1.5 kg, 33% with a birth weight of 1.5-2 kg and 20% with a birth weight of <1 kg.75% of the study population were hospitalized for >1 week. In the study group 58% had feed intolerance, 52.5% needed ventilator support, 52.5% had temperature instability, 70% had thrombocytopenia 50% had apnea and 4% had hyperglycemia. The overall survival was 60%.Conclusions: Prematurity, low birth weight and prolonged hospital stay were associated with increased risk of candidiasis. Feed intolerance, increased need for ventilator support, apnea, temperature instability and thrombocytopenia were significant clinical parameters.

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“…Goudjil et al showed that the optimal BDG cut-off for the identification of neonates with invasive candidiasis was 125 pg/ml (and not 80 pg/ml as suggested for adults) resulting in a sensitivity and specificity of 84% and 75%, respectively [40]. Two paediatric studies assessing the value of serum BDG in the diagnosis of IFD (mainly IA) showed that this test is not a reliable efficient diagnostic tool in the paediatric patients with hematologic disorders ( n = 62) and HSCT recipients ( n = 34) due to a high number of false-positive and false-negative results when 80 pg/ml was used as the cut-off (Table 1) [18, 41•].…”

Section: Fungal Biomarkersmentioning

confidence: 99%

Progress in the Diagnosis of Invasive Fungal Disease in Children

Warris

Lehrnbecher

2017

Curr Fungal Infect Rep

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Purpose of ReviewThis review summarizes the fungal diagnostic measures currently available for use in paediatric patients at high risk for developing invasive fungal disease (IFD) and those suspected of having an IFD. The clinical utility of each test is described based on reported performances of individual tests in specific paediatric populations.Recent FindingsAvailable studies in the paediatric population are scarce and are characterized by a huge heterogeneity in underlying diseases (e.g. different risk for IFD), different study objectives and management strategies (screening versus diagnostic) used.SummaryA final valuation of paediatric studies on fungal diagnostic tools is limited. While the galactomannan and fungal PCR assays are useful to exclude the presence of IFD, it is unclear if mannan, mannan antibodies and β-D-glucan are of benefit due to a lack of studies or validation of the cut-off, respectively. Well-designed multicentre paediatric studies are urgently needed to improve the outcome of IFD.

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(1–3)-β-D-glucan levels in candidiasis infections in the critically ill neonate

Abstract: Our study results suggest that BDG levels were increased in neonatal invasive Candida infections (cut-off for BDG positivity > 125 pg/ml). The change in the serum BDG levels may be of value in evaluating the efficacy of antifungal therapy.

Cited by 51 publications

References 28 publications

The Epidemiology and Diagnosis of Invasive Candidiasis Among Premature Infants

The Epidemiology and Diagnosis of Invasive Candidiasis Among Premature Infants

Clinical profile of neonatal candidiasis in newborn nursery

Progress in the Diagnosis of Invasive Fungal Disease in Children

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