1,3-Dipolar Cycloaddition Reactions Involving Captodative Olefins

Juarez, Rogelio Jimenez; Pérez, Lucelia; Tamariz, Joaquı́n; Salgado, Hector J.

doi:10.3987/com-92-s(t)70

Cited by 29 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our confusion, refracted through our relative security and privilege, stands as a counterpoint to that of the displaced, many of whom themselves have at best a partial understanding of the forces that intrude momentously into their lives. 67 The disorientation, however, is our own not theirs and, ironically perhaps, the imaginative acts from which it springs afford at least a partial basis from which to ponder the third of the questions Salgado provokes.…”

Section: Re-reading Salgadomentioning

confidence: 99%

See 1 more Smart Citation

‘The Arithmetic of Compassion’: Rethinking the Politics of Photography

Johnson¹

2011

Brit. J. Polit. Sci.

View full text Add to dashboard Cite

Compassion, theorists from Arendt to Nussbaum suggest, carries an ineluctable pressure to identify with individual suffering. The very idea of a politics of compassion verges on incoherence. Politics typically demands attention to the aggregate and it is just there that compassion falters. This is a problem for critics addressing the politics of photography, who typically presume that the point of photographs must be to elicit compassion among viewers. But a proper understanding of compassion makes this presumption highly problematic. The role of compassion in exemplary writings on the politics of photography reflects a fixation with ‘emblematic’ individual subjects in ‘classic’ American documentary practice, which prevents critics from properly grasping the best of contemporary documentary. The conclusion is that promoting solidarity provides a more plausible, if elusive, aim for the politics of photography.

show abstract

Section: Re-reading Salgadomentioning

confidence: 99%

“…84 Salgado understands this reality and takes liberties with it. 85 Recall the initial sequence of photographs in Migrations. My earlier discussion was concerned to illustrate how Salgado places images of individual hardship in the context of photographs depicting large populations.…”

Section: Photography and The Politics Of Solidaritymentioning

confidence: 99%

‘The Arithmetic of Compassion’: Rethinking the Politics of Photography

Johnson¹

2011

Brit. J. Polit. Sci.

View full text Add to dashboard Cite

show abstract

“…Indeed, due to the basic conditions needed for in situ nitrile oxide formation, abstraction of acidic proton H 4 promotes the aromatization into the corresponding isoxazoles via βelimination of the sugar ring oxygen. Jimenez et al had previously observed such rearrangement of activated olefins when reacted with nitrile oxides [33].…”

Section: Activated Exo-glycals As Dipolarophilesmentioning

confidence: 82%

Cycloaddition Reactions of Sugar-Based Olefins, Nitrones and Nitrile Oxides: En Route to Saccharidic Spiroisoxazoli(di)nes

Pellegrini‐Moise

Richard

2019

Topics in Heterocyclic Chemistry

View full text Add to dashboard Cite

Isoxazoline and isoxazolidine-containing compounds are privileged structures of interest, notably in synthetic and medicinal chemistry. These heterocycles can be obtained by 1,3dipolar cycloaddition reactions between an olefin and a nitrile oxide or a nitrone. This reaction generates the formation of one C-C and one C-O bond and up to three chiral centers in one step. In the present chapter, we aim to summarize and discuss reports of these cycloadditions on sugar olefins, with a focus on exo-methylene sugars or activated exoglycals, leading with high regio-and stereocontrol to saccharidic spiroisoxazoli(di)nes. Additional examples of cycloaddition reactions involving chiral nitrone, sugar nitrile oxide, sugar nitrone and also two chiral sugar partners will also be discussed. Due to the importance of the spiro structure in several biologically active compounds, these spiroheterocycles can be regarded as spironucleoside analogues, mimics of natural building blocks or multicyclic sugar scaffolds suitable for selective derivatization. Some of them thus showed promising biological properties as antibacterial agents or enzyme inhibitors. Moreover, the labile nature of the N−O bond in the isoxazolidine ring makes it an attractive target for synthetic chemists. The reactivity of this scaffold has therefore been widely studied and the cycloadducts have been converted to other classes of compounds of interest. Examples of the biological relevance and synthetic use and reactivity of these spiro-sugars will be given in this chapter.

show abstract

“…3,5-Disubstituted isoxazoles 6 , 7 , 9 and 10 (Table 1) have been previously prepared by different synthetic procedures, but compounds 6 [52], 7 [49] and 10 [53] have been only partly characterized, while for compound 9 [54] no characterization data have been reported.…”

Section: Resultsmentioning

confidence: 99%

Isoxazole derivatives as new nitric oxide elicitors in plants

Oancea

Georgescu²,

Georgescu

et al. 2017

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated alkynes in the presence of catalytic amounts of copper(I) iodide. Effects of 3,5-disubstituted isoxazoles on nitric oxide and reactive oxygen species generation in Arabidopsis tissues was studied using specific diaminofluoresceine dyes as fluorescence indicators.

show abstract

1,3-Dipolar Cycloaddition Reactions Involving Captodative Olefins

Cited by 29 publications

References 0 publications

‘The Arithmetic of Compassion’: Rethinking the Politics of Photography

‘The Arithmetic of Compassion’: Rethinking the Politics of Photography

Cycloaddition Reactions of Sugar-Based Olefins, Nitrones and Nitrile Oxides: En Route to Saccharidic Spiroisoxazoli(di)nes

Isoxazole derivatives as new nitric oxide elicitors in plants

Contact Info

Product

Resources

About