1,3‐Dinitrobenzene: Toxic effects<i>in vivo</i>and<i>in vitro</i>

Cody, Terence E.; Witherup, S.; Hastings, Lloyd; Stemmer, Kerstin; Christian, Robert T.

doi:10.1080/15287398109530024

Cited by 81 publications

(48 citation statements)

References 10 publications

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“…These results are in agreement with previous reports by other investigators. Cody et al, (1981) reported haematological disorders evidenced by decrease in PCV and RBC in rats exposed to 1, 3 -dinitrobenzene. Leighton (1990) also observed decreases in PCV and an increase in corpuscular HB in rats exposed to Prudhoe Bay crude oil.…”

Section: Discussionmentioning

confidence: 99%

Haematoxic Effects Following Ingestion Of Nigerian Crude Oil And Crude Oil Polluted Shellfish By Rats

et al. 2005

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Summary:The haematological effects following ingestion of shellfish exposed to crude oil polluted water or the pollutant perse were investigated in albino Wistar rats. Feeding of four groups of rats for 28 days duration with two reference casein or shellfish protein control diets (Group A and B), and two test diets (Group C and D) supplemented at varying levels with shellfish which had been previously exposed to crude oil polluted water and the oral gavaging with crude oil at the rate of 3, 6 and 9 ml/kg body weight per day to three groups (groups II, III and IV respectively) of rats for 7 days duration resulted in changes in packed cell volume (PCV), red blood cell (RBC) and white blood cell (WBC) counts, and haemoglobin concentration (Hb) of rats. Group C and D respectively fed 10% and 20% polluted shellfish diets recorded significant (P < 0.05) decreases in PCV and RBC counts while Hb concentration and WBC counts increased. Groups II, III and IV gavaged with varying doses of crude oil recorded significant (P < 0.05 -0.01) dose dependent decrease in PCV and RBC counts when compared to controls (group 1). Hb and WBC counts also increased for these groups but the increase was only significant for WBC counts (P < 0.05) when compared with controls. The results suggest that the ingestion of shellfish exposed to crude oil polluted water or the polluted perse results in haematotoxicity.

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Section: Discussionmentioning

confidence: 99%

Haematoxic Effects Following Ingestion Of Nigerian Crude Oil And Crude Oil Polluted Shellfish By Rats

et al. 2005

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“…This study revealed significant reduction in packed cell volume of the treated groups, thus corroborating the previous findings on the effects of hydrocarbon on erythropoietin. It has been shown that hydrocarbon causes bone marrow hypoplasia, consequently reducing red blood cell and white blood cell formation (Eyong et al, 2004, Cody et al, 1981. Leighton (1990), reported heamolytic anaemia in mice given crude oil.…”

Section: Discussionmentioning

confidence: 99%

“…Leighton (1990), reported heamolytic anaemia in mice given crude oil. Cody et al (1981), reported heamatological disorder evidenced by a decrease in PCV and red blood count in rat exposed to 1, 3 dinitrobenzene. Hydrocarbon has been reported to contribute to hemolytic anemia by Eyong et al (2004).…”

Section: Discussionmentioning

confidence: 99%

Effects of Nigeria Ekete light crude oil on plasma electrolytes, packed cell volume (PCV) and lipids profile in wistar (Rattus norvegicus) rats

Ojo¹,

Jaja²,

Bamidele³

et al. 2015

Afr. J. Biotechnol.

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Hydrocarbon is known to alter blood parameters; some of these blood parameters may affect the activities of certain systems like cardiovascular system. Hydrocarbon gets into man and animal either through ingestion of contaminated food and water, bio-concentration through food chain, occupational exposure or by using hydrocarbon products. Effects of crude oil on plasma electrolytes, packed cell volume (PCV) and plasma lipid profile were examined in male Rattus norvegicus in this study. Crude oil was administered orally at dosages of 5 ml/kg (group I), 10 ml/kg (group II) and 20 ml/kg (group III) for two weeks while the control group received drinking water only. The result shows a reduction in packed cell volume in all treated groups compared to control (37.14±0.85, P < 0.05) and a significant (P < 0.05) increase in plasma sodium level in treated groups compared to control (22.486±2.983 mg/L) while there was no significant alteration in plasma lipids profile of the treated groups relative to the control. Oral administration of crude oil significantly altered the plasma levels of electrolytes and PCV.

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“…This study identified a lowest-observed-effect-level (LOEL) of 8 ppm for increased splenic weight and a no-observed-effect-level (NOAEL) of 3 ppm (0.40 mg/kgday) (Cody et al 1981). The RfD was calculated using the NOAEL and an uncertainty factor of 3,000.…”

Section: 4-dimethylphenolmentioning

confidence: 99%

Preliminary Risk Assessment for Eight Selected Study Areas. Volume II

ABINGDON¹

1996

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1,3‐Dinitrobenzene: Toxic effectsin vivoandin vitro

Cited by 81 publications

References 10 publications

Haematoxic Effects Following Ingestion Of Nigerian Crude Oil And Crude Oil Polluted Shellfish By Rats

Haematoxic Effects Following Ingestion Of Nigerian Crude Oil And Crude Oil Polluted Shellfish By Rats

Effects of Nigeria Ekete light crude oil on plasma electrolytes, packed cell volume (PCV) and lipids profile in wistar (Rattus norvegicus) rats

Preliminary Risk Assessment for Eight Selected Study Areas. Volume II

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