1,3-Benzodithiolium cation mediated cyclization reactions

Highly Enantioselective α Alkylation of Aldehydes with 1,3‐Benzodithiolylium Tetrafluoroborate: A Formal Organocatalytic α Alkylation of Aldehydes by the Carbenium Ion

“…Not only can the organocatalytic α alkylation of 3 constitute the addition of a formyl equivalent, but the introduction of the 1,3‐benzodithiol group in a stereoselective fashion can also allow the generation of an anionic ( 2 ) or cationic ( 3 ) equivalent. Furthermore, deprotection of 1,3‐benzothiole with Raney Ni can give direct access to a methyl group 13. Herein we report the first practical and highly organocatalytic stereoselective addition of the commercially available cation 3 a to various functionalized aldehydes and the easy functionalization of the isolated adducts.…”

Functionalized (Benzotriazol-1-yl)methanes as 1,1-Dipole Synthon Equivalents in Diverse Annulations to Aromatic and Heteroaromatic Rings

“…Aromatic annulations which form carbocyclic derivatives possessing latent functionality are of considerable utility due to their potential applications in the elaboration of natural products …”

A Nozaki−Hiyama−Kishi Ni(II)/Cr(II) Coupling Approach to the Phomactins

“…Our approach began with the NaBH 4 reduction of ketone 4 , which furnished the corresponding alcohol as a single stereoisomer (Scheme ) . After protection with TBSOTf, the benzodithiane group was removed upon oxidation with NBS. , Resultant ketone 5 was then converted to its methyl enol ether with KHMDS/MeOTf.…”