“…CA has been incorporated into libraries based on peptide [5,37,38], triazine [39], and piperidine [40] scaffolds, leading to the identification of covalent modifiers for nitrilases [37,38], protein disulfide isomerase (PDI) [39], and GSTO1 [40]. The more reactive IA covalently modifies 1000 cysteines in the proteome [7], enabling the global profiling of changes in cysteine reactivity.…”