1,3,4-Oxadiazole Derivatives. Optical Properties in Pure and Mixed Solvents

Abstract

1,3,4-Oxadiazole derivatives-organic materials are an interesting and continuously developing area of research. This review describes some optical properties and highlights the current applications of these compounds in biomedical and optoelectronic fields. The relationships between polymer structures, environmental factors and optical properties (absorption and fluorescence) of several selected and relevant l,3,4-oxadiazole-containing molecules were presented in this review. These aspects were analyzed in various pure solvents and microheterogeneous media (mixed solvents). Also, the selectivity and sensitivity of some 1,3,4-oxadiazole derivatives-organic materials for different metal ions were discussed and evaluated by using spectral techniques. Finally, some important photophysical characteristics of 34 series of organic materials containing -1,3,4-oxadiazole rings, were collected in a table.

Batch Versus Flow Lithiation–Substitution of 1,3,4‐Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry

“…Oxadiazoles occupy an important role in modern medicinal chemistry, [1] often acting as bioisosteres of carboxylate derivatives including amides, [2] esters, [2] carbamates [3] and hydroxamic esters [4] as well as attracting attention for their optoelectronic properties. [5] In almost all cases the 1,3,4-isomere xhibits pharmacologically favourable activityw ith respectt ol ipophilicity (log D), hERG inhibition and metabolic stability. [1] Examples of bioactive 1,3,4-oxadiazoles includer altegravir with an antiretroviral activity [6] and zibotentan as an endothelin receptor antagonist [7] (Figure 1).…”

Regioselective Synthesis of 2,5-Disubstituted-1,3,4-thiadiazoles and 1,3,4-Oxadiazoles via Alkyl 2-(Methylthio)-2-thioxoacetates and Alkyl 2-Amino-2-thioxoacetates

“…Among them, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles have been employed as dominant scaffolds to produce a variety of medicinal actions including anti-inflammatory, anti-fungal, anti-bacterial, anti-viral, anti-cancer effects, and also these moieties are found in commercially available drugs (Figure ). Especially, in the field of material sciences, the fundamental core of 1,3,4-thiadiazoles and 1,3,4-oxadiazoles has been extensively utilized in liquid crystals, organic light-emitting diodes, solar cells, and agro-products . Hence, there is a constant effort towards the synthesis of 1,3,4-thiadiazoles and 1,3,4-oxadiazoles needed.…”

Improved electroluminescence efficiency derived from functionalized decoration of 1,3,4-oxadiazole (OXD)-based Ir(iii) complexes

“…1,3,4-Oxadiazole (OXD), as an electron-withdrawing unit, has been widely incorporated into organic small molecules for achieving electron transporting or hole blocking functional materials in organic light emitting devices (OLEDs). [1][2][3][4][5] The lone pair electrons of the nitrogen atom in OXD can coordinate with transition metals to form various metal-organic frameworks, including copper(II) (Cu 2+ ), 6,7 platinum(II) (Pt 2+ ), 8 iridium(III) (Ir 3+ ), 9,10 etc. Among these complexes, Ir(III) complexes can utilize the full electro-generated excitons (25% from singlet and 75% from triplet) for emission, which is due to the heavy atom effect leading to single-triplet mixing.…”