1-[3-(4-Fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Abstract

In the title compound, C17H15FN2O, the pyrazoline ring adopts a flattened envelope conformation. The dihedral angle between the fluoro-substituted benzene ring and the phenyl ring is 69.20 (5)°. In the crystal, a pair of C—H⋯O hydrogen bonds link neighbouring mol­ecules, forming an inversion dimer. The crystal structure is further consolidated by C—H⋯π inter­actions and by a π–π inter­action with a centroid–centroid distance of 3.7379 (6) Å.

Synthesis and Crystal Structures of N-Substituted Pyrazolines

“…In view of importance of pyrazolines and in continuation of our work on the synthesis and structure determination of various pyrazoline derivatives [ 12 , 13 , 14 , 15 ], we report the synthesis and crystal structures of four novel N -substituted pyrazolines.…”

2'-[(4-Fluorophenyl)carbonyl]-1'-phenyl-1',2',5',6',7',7a'-hexahydrospiro[indole-3,3'-pyrrolizin]-2(1H)-one

“…Chalcones are highly reactive substances of varied nature. The basic skeleton of chalcones which possess α,β-unsaturated carbonyl group is useful as the starting material for the synthesis of various biodynamic heterocyclic compounds such as pyrazolines, isoxazolines, pyridines, pyrimidines, benzodiazepines and cyclohexenone derivatives [7][8][9][10][11]. In addition, multicomponent reactions of chalcones with various components yield 2,4,6-triaryl pyridines [12], spiro pyrrolizines [13][14][15], cyanopyridines [16] etc.…”

3-Methoxy-2-[5-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenol

“…For the synthesis and biological properties of pyrazoline derivatives, see: Hwang et al (2013); Sharifzadeh et al (2013); Congiu et al (2010); Khode et al (2009); Karthikeyan et al (2007). For related structures, see: Fun et al (2012); Jasinski et al (2010). For hydrogen-bond graph-set notation, see: Bernstein et al (1995).…”

“…In addition, each molecule contains an intramolecular O-H•••N hydrogen bond with an S(6) notation. Some examples of pyrazoline structures have been published (Fun et al, 2012;Jasinski et al, 2010).…”