1,25(OH)2-Vitamin D3 Inhibits Proliferation and Decreases Production of Monocyte Chemoattractant Protein-1, Thrombopoietin, VEGF, and Angiogenin by Human Annulus Cells In Vitro

Gruber, Helen E.; Hoelscher, Gretchen L.; Ingram, Jane A.; Chow, Yin; Loeffler, Bryan J.; Hanley, Edward N.

doi:10.1097/brs.0b013e3181695d59

Cited by 52 publications

(47 citation statements)

References 60 publications

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“…The correlation of VDR loss with increased levels of proangiogenic factors suggested that VDR had direct and/or indirect suppressive effects on the transcription of these factors. Such inhibitory effects were also observed in other cell models, including human annulus and neutrophil cells and Kaposi sarcoma cells (33,42,62). Interestingly, VDR was also shown to improve the angiogenic properties of endothelial progenitor cells by inducing various factors, including VEGF (34).…”

Section: Effects Of Vdr Signaling Activation In Tumor Endothelium In mentioning

confidence: 69%

Role of androgen and vitamin D receptors in endothelial cells from benign and malignant human prostate

Godoy

Chung

Montecinos

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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Forty years ago, Judah Folkman (Folkman. N Engl J Med 285: 1182-1186, 1971 proposed that tumor growth might be controlled by limiting formation of new blood vessels (angiogenesis) needed to supply a growing tumor with oxygen and nutrients. To this end, numerous "antiangiogenic" agents have been developed and tested for therapeutic efficacy in cancer patients, including prostate cancer (CaP) patients, with limited success. Despite the lack of clinical efficacy of lead antiangiogenic therapeutics in CaP patients, recent published evidence continues to support the idea that prostate tumor vasculature provides a reasonable target for development of new therapeutics. Particularly relevant to antiangiogenic therapies targeted to the prostate is the observation that specific hormones can affect the survival and vascular function of prostate endothelial cells within normal and malignant prostate tissues. Here, we review the evidence demonstrating that both androgen(s) and vitamin D significantly impact the growth and survival of endothelial cells residing within prostate cancer and that systemic changes in circulating androgen or vitamin D drastically affect blood flow and vascularity of prostate tissue. Furthermore, recent evidence will be discussed about the expression of the receptors for both androgen and vitamin D in prostate endothelial cells that argues for direct effects of these hormone-activated receptors on the biology of endothelial cells. Based on this literature, we propose that prostate tumor vasculature represents an unexplored target for modulation of tumor growth. A better understanding of androgen and vitamin D effects on prostate endothelial cells will support development of more effective angiogenesis-targeting therapeutics for CaP patients.androgens; androgen receptor; vitamin D; endothelium; prostate cancer

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Section: Effects Of Vdr Signaling Activation In Tumor Endothelium In mentioning

confidence: 69%

Role of androgen and vitamin D receptors in endothelial cells from benign and malignant human prostate

Godoy

Chung

Montecinos

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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“…More recently some studies detected the presence of VDR also in the disc cells, highlighting the prominent role of vitamin D active metabolites in the regulation of cells proliferation, matrix genes expression and specific cytokines and proteins production [32], [33].…”

Section: Introductionmentioning

confidence: 99%

FokI Polymorphism in the Vitamin D Receptor Gene (VDR) and Its Association with Lumbar Spine Pathologies in the Italian Population: A Case-Control Study

et al. 2014

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Alterations in vitamin D homeostasis, mainly involving its nuclear receptor (VDR), could have a role in the pathophysiology of the spine. The association between VDR polymorphisms and spine disorders has been analyzed in different ethnic groups, focusing on the functional FokI polymorphism. However, so far, inconsistent findings were reported. The aims of this study were to evaluate, in the Italian white population, the VDR FokI polymorphism frequencies distribution in subjects with clearly defined lumbar spinal pathologies compared to asymptomatic controls and to analyze the interplay of genetic and conventional risk factors. Using a case-control design, 267 patients with spinal disorders and 220 asymptomatic controls were enrolled, evaluating their exposition to putative risk factors. Patients’ clinical assessment was performed by Magnetic Resonance Imaging. FokI polymorphism (rs2228570) was detected by PCR-RFLP. Genotypes were designated by a lowercase letter (f allele, T nucleotide) for the presence of the restriction site and by a capital letter (F allele, C nucleotide) for its absence. Family history, higher age and BMI, exposure to vibration, physical job demand, smoking habit and lower practice of leisure physical activity were associated with spinal disorders. The FF genotype and F allele represented approximately 2-fold risk factors to develop discopathies and/or osteochondrosis concomitant with disc herniation, while f allele was protective. In conclusion, the link we observed between VDR FokI variants and specific lumbar spine pathologies suggests that spinal tissue degeneration is influenced by the genetic background. Future studies should evaluate the signaling pathways involving alterations in VDR and influencing the development and/or progression of spine disorders.

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“…One of the factors playing a role in these molecular processes is the vitamin D system. Of note, VDRs (vitamin D receptors) are expressed in osteoblasts, chondrocytes, and annulus fibrosus and nucleus pulposus cells of the discs [34]. In addition, vitamin D has been demonstrated to affect the proliferation and functional regulation of these cells and their production of certain proteins and cytokines in vitro .…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that vitamin D is involved in proliferation, differentiation, and maturation of chondrocytes [1], synthesis of proteoglycans— making up the matrix of intervertebral discs— and also in regulation of plasma sulfate levels required for intracellular sulfation of proteoglycans [2]. For the health of intervertebral discs, active metabolites of vitamin D regulate proliferation, expression of matrix genes and production of certain proteins and cytokines in cells of annulus fibrosus and nucleus pulposus, the two macrostructural components of the discs [34]. …”

Section: Introductionmentioning

confidence: 99%

A Survey of Vitamin D Status in Patients with Degenerative Diseases of the Spine

et al. 2016

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Study DesignDescriptive cross-sectional study.PurposeTo determine the prevalence of vitamin D deficiency in patients with degenerative diseases of the spine about to undergo spinal surgery and the relations between such deficiency and potential risk factors.Overview of LiteratureVitamin D has a major role in musculoskeletal system health maintenance. Recently, studies on degenerative diseases of the spine have shown a high prevalence of vitamin D deficiency in patients undergoing spine surgery.MethodsSerum levels of 25(OH)D were determined by an electrochemiluminescence detection assay. The other variables were determined through relevant questionnaires, and the data was analyzed through analysis of variance, t-test, chi-square and multivariate logistic regression analysis.ResultsA total of 110 patients were enrolled in the study. The mean serum level of 25(OH)D was 27.45±18.75 ng/mL, and 44.5% of patients showed vitamin D deficiency (25(OH)D<20 ng/mL), with an additional 17.3% of patients having a serum level of 25(OH)D that was insufficient (20≤25(OH)D<30 ng/mL). The prevalence of vitamin D deficiency was significantly higher in the younger age group compared to the older age group (p<0.001) and the ones without a history of taking vitamin D supplements (p=0.013). Compared to men, women showed significantly higher levels of vitamin D (p=0.029).ConclusionsA high prevalence of vitamin D deficiency is seen in patients with degenerative diseases of the spine. On the other hand, the conventional risk factors such as old age or female sex alone did not seem to be sufficient in determining the likelihood of deficiency. Thus, it is recommended that vitamin D deficiency prevention strategies comprise a broader spectrum of the population through which such degenerative diseases and their consequences may be prevented or delayed.

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1,25(OH)2-Vitamin D3 Inhibits Proliferation and Decreases Production of Monocyte Chemoattractant Protein-1, Thrombopoietin, VEGF, and Angiogenin by Human Annulus Cells In Vitro

Abstract: Data suggest that 1,25(OH)2D3 and 24,25-D3 may play roles as regulators of cell proliferation and production of specific cytokines in the lumbar anulus.

Cited by 52 publications

References 60 publications

Role of androgen and vitamin D receptors in endothelial cells from benign and malignant human prostate

Role of androgen and vitamin D receptors in endothelial cells from benign and malignant human prostate

FokI Polymorphism in the Vitamin D Receptor Gene (VDR) and Its Association with Lumbar Spine Pathologies in the Italian Population: A Case-Control Study

A Survey of Vitamin D Status in Patients with Degenerative Diseases of the Spine

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