1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro.

Lemire, Jacques; Adams, John S.; Kermani-Arab, Vali; Bakke, Antony C.; Sakai, Rebecca; Jordan, Stanley C.

doi:10.4049/jimmunol.134.5.3032

Cited by 280 publications

(17 citation statements)

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“…36,37 Several studies have shown that vitamin D inhibits the synthesis and secretion of IL-2, IL-4, and IFN-γ and increases the expression of IL-5. [38][39][40][41][42][43][44] When compared to the results of our study on IL-2 and IL-4, the results are the opposite. Despite many controversies surrounding the effect of vitamin D on cytokine expression in patients with systemic lupus erythematosus, the results support the suggestion that reducing vitamin D3 deficiency is an effective way to control lupus.…”

Section: Discussionmentioning

confidence: 74%

The in vitro effects of vitamin 1, 25(OH) 2 D3 on expression of cytokines: In new-onset systemic lupus erythematosus patients

Chegni

Heidarvand

2022

Lupus

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Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting a variety of factors in the immune system. Awareness of the role of cytokines in SLE has led to new clinical perspectives in its pathogenesis; therefore, the aim of this study was to investigate the effect of vitamin 1, 25(OH) 2 D3 (D3) on the expression of IL-2, IL-4, IL-5, IL-10, and IFN-γ cytokines in patients with lupus. Methods: A total of 65 new-onset SLE patients were enrolled in the study. After peripheral blood mononuclear cell isolation, the lymphocytes of each patient were divided into two groups, one treated with a concentration of 50 μmol vitamin D3 (test) and the other untreated with vitamin D3 (control), were cultured. After 24 hours, the cultured cells were collected and the expressions of IL-2, IL-4, IL-5, IL-10, and IFN-γ genes were analyzed by RT-qPCR. Results: It was observed that vitamin D3 reduced expression of IFN-γ, IL-4, IL-5, and IL-10 genes by 73, 50, 37, and 29%, respectively, and increased IL-2 gene expression by 31% ( p ≤ 0.05). Conclusion: With different patterns of cytokine changes in patients with lupus in different studies, it seems that the pattern of cytokine changes is largely dependent on the phase of the disease and with this study it can be concluded that vitamin D3 administration at the time of diagnosis and in the early stages and before starting treatment have different effects from its administration in the acute stage of the disease, which requires further studies to prove. It seems that in patients with systemic lupus erythematosus, vitamin D should be administered taking into account the phase of the disease.

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Section: Discussionmentioning

confidence: 74%

The in vitro effects of vitamin 1, 25(OH) 2 D3 on expression of cytokines: In new-onset systemic lupus erythematosus patients

Chegni

Heidarvand

2022

Lupus

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“…59,61 Although the underlying mechanisms of vitamin D's protection against severe COVID-19 are unknown, it is established that vitamin D reduces the production of proinflammatory cytokines such as Th1, TNF-α, interferon-β, IL-6, and promotes the production of anti-inflammatory responses such as T regulatory cells and Th2. 49,59,[62][63][64] There are several explanations for vitamin D's beneficial effects on critically ill patients. Initially, critically ill patients who are given vitamin D supplements will have their plasma vitamin D concentrations restored.…”

Section: Discussionmentioning

confidence: 99%

Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients

Rachman

Rahmaniyah²,

Khomeini³

et al. 2023

F1000Res

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Background: Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. Vitamin D has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, the role of vitamin D in COVID-19 infection remains controversial. This study aimed to analyze the impact of vitamin D deficiency on the clinical outcome of hospitalized COVID-19 patients. Methods: A prospective cohort study was conducted among hospitalized COVID-19 patients at two COVID-19 referral hospitals in Indonesia from October 2021 until February 2022. Results: The median serum 25(OH)D level in 191 hospitalized COVID-19 patients was 13.6 [IQR=10.98] ng/mL. The serum 25(OH)D levels were significantly lower among COVID-19 patients with vitamin D deficiency who had cardiovascular disease (p-value=0.04), the use of a ventilator (p-value=0.004), more severe COVID-19 cases (p-value=0.047), and mortality (p-value=0.002). Furthermore, serum 25(OH)D levels were significantly different between patients with mild and severe COVID-19 cases (p-value=0.019). Serum 25(OH)D levels in moderate and severe COVID-19 cases were significantly different (p-value=0.031). Lower serum 25(OH)D levels were significantly associated with an increased number of comorbidities (p-value=0.03), the severity of COVID-19 (p-value=0.002), and the use of mechanical ventilation (p-value=0.032). Mortality was found in 7.3% of patients with deficient vitamin D levels. However, patients with either sufficient or insufficient vitamin D levels did not develop mortality. Conclusions: COVID-19 patients with vitamin D deficiency were significantly associated with having cardiovascular disease, mortality, more severe COVID-19 cases, and the used of mechanical ventilation. Lower serum 25(OH)D levels were associated with an increased number of comorbidities, COVID-19 severity, and the use of mechanical-ventilation. Thus, we suggest hospitalized COVID-19 patients to reach a sufficient vitamin D status to improve the clinical outcome of the disease.

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“…The immunosuppressive effect of VD 3 is correlated with a decrease in the expression and consequent release of inflammatory cytokines, including IL-2 and IFN-γ ( Lemire et al ., 1985 ).…”

Section: Steroid Hormonesmentioning

confidence: 99%

Vitamin D and estrogen steroid hormones and their immunogenetic roles in Infectious respiratory (TB and COVID-19) diseases

2023

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The role of steroid hormones against infectious diseases has been extensively studied. From immunomodulatory action to direct inhibition of microorganism growth, hormones D 3 (VD 3 ) and 17β-estradiol (E 2 ), and the genetic pathways modulated by them, are key targets for a better understanding pathogenesis of infectious respiratory diseases (IRD) such as tuberculosis (TB) and the coronavirus disease-19 (COVID-19). Currently, the world faces two major public health problems, the outbreak of COVID-19, accounting for more than 6 million so far, and TB, more than 1 million deaths per year. Both, although resulting from different pathogens, the Mtb and the SARS-CoV-2 , respectively, are considered serious and epidemic. TB and COVID-19 present similar infection rates between men and women, however the number of complications and deaths resulting from the two infections is higher in men when compared to women in childbearing age, which may indicate a role of the sex hormone E 2 in the context of these diseases. E 2 and VD 3 act upon key gene pathways as important immunomodulatory players and supporting molecules in IRDs. This review summarizes the main roles of these hormones (VD 3 and E 2 ) in modulating immune and inflammatory responses and their relationship with TB and COVID-19.

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1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro.

Cited by 280 publications

References 0 publications

The in vitro effects of vitamin 1, 25(OH) 2 D3 on expression of cytokines: In new-onset systemic lupus erythematosus patients

The in vitro effects of vitamin 1, 25(OH) 2 D3 on expression of cytokines: In new-onset systemic lupus erythematosus patients

Impact of vitamin D deficiency in relation to the clinical outcomes of hospitalized COVID-19 patients

Vitamin D and estrogen steroid hormones and their immunogenetic roles in Infectious respiratory (TB and COVID-19) diseases

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