1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter

Cardús, Anna; Panizo, Sara; Encinas, Mario; Dolcet, Xavier; Gallego, Carme; Aldea, Martí; Fernàndez, Elvira; Valdivielso, José M.

doi:10.1016/j.atherosclerosis.2008.08.020

Cited by 148 publications

(105 citation statements)

References 35 publications

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“…According to studies performed on rat aorta, vitamin D 3 plays a role in maintaining vascular reactivity and the vascular effects of sex hormones via creatine kinase activity (40). Increased vascular endothelial growth factor expression may also take part in the chronic vasoprotective effects of vitamin D 3 (41).…”

Section: Figurementioning

confidence: 99%

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Sára

Péter

Masszi

et al. 2012

Fertility and Sterility

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Objective: To investigate the vascular dysfunction caused by insulin resistance in polycystic ovary syndrome (PCOS) and the effectiveness of vitamin D in an animal model. Design: Controlled experimental animal study. Setting: Animal laboratory at a university research institute. Animal(s): Thirty female Wistar rats. Intervention(s): Rats were divided into groups at age 21-28 weeks. Twenty of them were subjected to dihydrotestosterone (DHT) treatment (83 mg/d); ten of them also received parallel vitamin D treatment (120 ng/100 g/wk). Oral glucose tolerance tests with insulin level measurements were performed. Gracilis arterioles were tested for their contractility as well as their nitric oxide (NO)-dependent and insulin-induced dilation using pressure arteriography. Main Outcome Measure(s): Several physiologic parameters, glucose metabolism, and pressure arteriography. Result(s): DHT treatment increased the passive diameter of resistance arterioles, lowered norepinephrine-induced contraction (30.1 AE 4.7% vs. 8.7 AE 3.6%) and reduced acetylcholine-induced (122.0 AE 2.9% vs. 48.0 AE 1.4%) and insulin-induced (at 30 mU/mL: 21.7 AE 5.3 vs. 9.8 AE 5.6%) dilation. Vitamin D treatment restored insulin relaxation and norepinephrine-induced contractility; in contrast, it failed to alter NO-dependent relaxation.

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Section: Figurementioning

confidence: 99%

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Sára

Péter

Masszi

et al. 2012

Fertility and Sterility

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“…In addition, the VEGF promoter is regulated by progesterone (Wu et al 2004), vitamin D (Cardus et al 2009), and the liver-X nuclear receptors (LXR) (Walczak et al 2004). Nuclear receptors recruit multiple enzymatically diverse epigenetic coregulators, including p160/p300 lysine acetyltransferase, demethylases that cooperate with the mediator complex to stabilize recruitment of the basal transcriptional machinery, and RNA polymerase II.…”

Section: Transcriptional Regulation Of Pro-angiogenesis Pathways In Pcamentioning

confidence: 99%

Regulation of vascular endothelial growth factor in prostate cancer

Brot¹,

Ntekim²,

Cardenas³

et al. 2015

Endocrine-Related Cancer

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Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to w30% will experience local recurrence or metastatic disease. Prostate carcinogenesis and progression is typically an androgen-dependent process. For this reason, therapies for recurrent PCa target androgen biosynthesis and androgen receptor function. Such androgen deprivation therapies (ADT) are effective initially, but the duration of response is typically %24 months. Although ADT and taxane-based chemotherapy have delivered survival benefits, metastatic PCa remains incurable. Therefore, it is essential to establish the cellular and molecular mechanisms that enable localized PCas to invade and disseminate. It has long been accepted that metastases require angiogenesis. In the present review, we examine the essential role for angiogenesis in PCa metastases, and we focus in particular on the current understanding of the regulation of vascular endothelial growth factor (VEGF) in localized and metastatic PCa. We highlight recent advances in understanding the role of VEGF in regulating the interaction of cancer cells with tumor-associated immune cells during the metastatic process of PCa. We summarize the established mechanisms of transcriptional and post-transcriptional regulation of VEGF in PCa cells and outline the molecular insights obtained from preclinical animal models of PCa. Finally, we summarize the current state of anti-angiogenesis therapies for PCa and consider how existing therapies impact VEGF signaling.

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“…The macrovascular association may be attributable to effects on blood pressure [16], rennin-angiotensin system activity [17], endothelial function [3], vascular endothelial growth factor [18] or chronic inflammation. Doubt remains as to whether low vitamin D levels are causal or merely a marker of worse disease or worse health status.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis

2012

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Aims To systematically review the evidence for the effect of vitamin D supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes.Methods Systematic review and meta-analysis. We searched databases including MEDLINE, EMBASE and the Cochrane Library for randomized controlled trials comparing vitamin D or analogues with placebo. We extracted data on fasting glucose, glycaemic control, insulin resistance, insulin ⁄ C-peptide levels, micro-and macrovascular outcomes and progression from non-diabetes to diabetes. Studies were assessed independently by two reviewers according to a pre-specified protocol.Results Fifteen trials were included in the systematic review. Trial reporting was of moderate, variable quality. Combining all studies, no significant improvement was seen in fasting glucose, HbA 1c or insulin resistance in those treated with vitamin D compared with placebo. For patients with diabetes or impaired glucose tolerance, meta-analysis showed a small effect on fasting glucose ()0.32 mmol ⁄ l, 95% CI )0.57 to )0.07) and a small improvement in insulin resistance (standard mean difference )0.25, 95% CI )0.48 to )0.03). No effect was seen on glycated haemoglobin in patients with diabetes and no differences were seen for any outcome in patients with normal fasting glucose. Insufficient data were available to draw conclusions regarding micro-or macrovascular events; two trials failed to show a reduction in new cases of diabetes in patients treated with vitamin D.Conclusions There is currently insufficient evidence of beneficial effect to recommend vitamin D supplementation as a means of improving glycaemia or insulin resistance in patients with diabetes, normal fasting glucose or impaired glucose tolerance.Diabet. Med. 29, e142-e150 (2012)

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1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter

Cited by 148 publications

References 35 publications

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Regulation of vascular endothelial growth factor in prostate cancer

Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta‐analysis

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