1,25-Dihydroxyvitamin D3 receptors in the central nervous system of the rat embryo

Veenstra, Timothy D.; Prüfer, Kirsten; Koenigsberger, Carol; Brimijoin, Stephen; Grande, Joseph P.; Kumar, Rajiv

doi:10.1016/s0006-8993(98)00565-4

Cited by 147 publications

(95 citation statements)

References 43 publications

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“…mone in tissues, which are not primarily related to mineral metabolism, have been shown within last 30 years. Vitamin D is suggested to act as a neuroactive steroid due to the local bioactivation of the pre-vitamin D hormone in the central nervous system (CNS) and the widely distributed localization of nuclear receptor throughout the brain (Luine et al 1987;Musiol et al 1992;Elaroussi et al 1994;Johnson et al 1996;Veenstra et al 1998;Prufer et al 1999;Miller and Portale 2000;Langub et al 2001;Garcion et al 2002;Burkert et al 2003;Eyles et al 2005;McCann and Ames. 2008;Cekic et al 2009;Dickens et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

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et al. 2012

Tohoku J. Exp. Med.

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Vitamin D 3 is a neurosteroid that mediates its effects via the vitamin D receptor (VDR). The VDR gene is located on chromosome 12q13 and consists of 9 exons. VDR contains the DNA-binding site encoded by exons 2 and 3 and the ligand-binding site encoded by exons 4 -9. Our earlier study showed that the ApaI polymorphic site of the VDR gene is associated with late-onset Alzheimer's disease (AD). Here, we investigated the association between additional polymorphisms of the VDR gene and AD using the same samples. Two single nucleotide polymorphisms (SNPs) in intron 8 (BsmI and Tru9I polymorphisms) and one in exon 2 (FokI polymorphism) of the VDR gene were examined in up to 108 AD patients and 115 age-matched controls. Genotypes were determined with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Haplotype analysis also included the previously studied polymorphic sites that were recognized by TaqI (in exon 9) and ApaI (in intron 8) restriction enzymes. There was no significant difference between AD patients and controls when their genotypes for BsmI, Tru9I and FokI polymorphic sites were compared. However, the frequency of "TaubF" haplotype (alleles of TaqI, ApaI, Tru9I, BsmI and FokI, respectively), which was determined by analyzing 5 polymorphisms together, was significantly higher in the AD patient group, suggesting that this haplotype is a risk factor in AD. Our results point out a possible link between AD and certain VDR polymorphisms and indicate that individuals with these polymorphisms might be vulnerable to AD.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Gezen-Ak

Dursun

Bılgıç

et al. 2012

Tohoku J. Exp. Med.

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“…The presence of Vitamin D receptors (VDR) in the hippocampus, hypothalamus, thalamus, cortex, and subcortex and substantia nigra [10] induced many studies, on the possible determinant role of vitamin D, in different neurological conditions [11][12]. Calcitriol is a fundamental actor in the neuronal differentiation and in the neural maturation [13].…”

Section: Methabolism and Biological Actions Of Vitamin Dmentioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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“…Evidence for a role of vitamin D in brain function began to accumulate over two decades ago with autoradiographic findings of vitamin D receptors in the brains of experimental animals (Stumpf, Sar et al 1982) and the demonstration that 1,25(OH) 2 D 3 was present in cerebrospinal fluid (Balabanova, Richter et al 1984). Animal studies revealed the presence of VDR in the neuroepithelium during early neurogenesis, and in later stages, in an area involved in the maintenance of neural stem cells, the subventricular zone (Veenstra 1998). More recent animal data confirm the expression of VDR in specific brain regions, including but not limited to, the temporal lobe, cingulate cortices, thalamus, cerebellum, amygdala and hippocampal regions (Clemens, Garrett et al 1988;Stumpf, Clark et al 1988;Prufer, Veenstra et al 1999;Langub, Herman et al 2001;Garcion, Wion-Barbot et al 2002;Eyles, Brown et al 2003;McGrath, Feron et al 2004).…”

Section: Vitamin D and The Brain: Mechanisms Of Actionmentioning

confidence: 99%