1,25-Dihydroxyvitamin D3 induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: A pilot study

Agraz‐Cibrián, Juan Manuel; Giraldo, Diana M.; Urcuqui-Inchima, Silvio

doi:10.1016/j.steroids.2018.11.001

Cited by 30 publications

(24 citation statements)

References 49 publications

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“…Recently, the formation of neutrophil extracellular traps (NETs) by vitamin D was explored; the production of these networks of extracellular fibers composed of DNA, histones, and enzymes that function to immobilize pathogens were enhanced by 1,25D. ( 75 ) However, the NETs‐like structures were not verified to be bona fide NETs. Moreover, 1,25D was reported to augment neutrophil killing of Streptococcus pneumoniae and also to lower inflammatory cytokine production by inducing the expression of the anti‐inflammatory cytokine IL‐4 and suppressor of cytokine signaling (SOCS) proteins.…”

Section: Vitamin D and Granulocyte Biologymentioning

confidence: 99%

Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti‐Inflammatory

et al. 2020

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Regulation of immune function continues to be one of the most well-recognized extraskeletal actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells such as macrophages could actively metabolize precursor 25-hydroxyvitamin D (25D) to active 1,25-dihydroxyvitamin D (1,25D). Parallel observation that activated cells from the immune system expressed the intracellular vitamin D receptor (VDR) for 1,25D suggested a potential role for vitamin D as a localized endogenous modulator of immune function. Subsequent studies have expanded our understanding of how vitamin D exerts effects on both the innate and adaptive arms of the immune system. At an innate level, intracrine synthesis of 1,25D by macrophages and dendritic cells stimulates expression of antimicrobial proteins such as cathelicidin, as well as lowering intracellular iron concentrations via suppression of hepcidin. By potently enhancing autophagy, 1,25D may also play an important role in combatting intracellular pathogens such as M. tuberculosis and viral infections. Local synthesis of 1,25D by macrophages and dendritic cells also appears to play a pivotal role in mediating T-cell responses to vitamin D, leading to suppression of inflammatory T helper (Th)1 and Th17 cells, and concomitant induction of immunotolerogenic Tregulatory responses. The aim of this review is to provide an update on our current understanding of these prominent immune actions of vitamin D, as well as highlighting new, less well-recognized immune effects of vitamin D. The review also aims to place this mechanistic basis for the link between vitamin D and immunity with studies in vivo that have explored a role for vitamin D supplementation as a strategy for improved immune health. This has gained prominence in recent months with the global coronavirus disease 2019 health crisis and highlights important new objectives for future studies of vitamin D and immune function.

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Section: Vitamin D and Granulocyte Biologymentioning

confidence: 99%

Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti‐Inflammatory

et al. 2020

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“…The expression and activity of PADs are regulated at multiple levels, including transcriptional, translational and post-translational levels (for a review see [13]). For example, 1-α, 25-dihydroxyvitamin D3 induces the expression of PAD mRNA in keratinocytes [16,17], and auto-deimination of PADs changes their tertiary structure and interferes with their enzymatic activity or protein-protein interactions [16,18,19]. The first and so far only biological regulator of PAD, namely the tyrosine-protein phosphatase non-receptor type 22 (PTPN22), was recently characterized as a non-enzymatic inhibitor of PAD4 [20].…”

Section: Introductionmentioning

confidence: 99%

Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

Méchin

Takahara

Simon

2020

IJMS

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Deimination, also known as citrullination, corresponds to the conversion of the amino acid arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post-translational modification is catalyzed by a family of calcium-dependent enzymes called peptidylarginine deiminases (PADs). Deimination is implicated in a growing number of physiological processes (innate and adaptive immunity, gene regulation, embryonic development, etc.) and concerns several human diseases (rheumatoid arthritis, neurodegenerative diseases, female infertility, cancer, etc.). Here, we update the involvement of PADs in both the homeostasis of skin and skin diseases. We particularly focus on keratinocyte differentiation and the epidermal barrier function, and on hair follicles. Indeed, alteration of PAD activity in the hair shaft is responsible for two hair disorders, the uncombable hair syndrome and a particular form of inflammatory scarring alopecia, mainly affecting women of African ancestry.

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“…TGFβ (Transforming growth factor α and β). CCL2, CCL3, CCL5 Chemokine (C-C motif) ligand 2,3.5) CXCL8, CXCL9, CXCL10: C-X-C (motif chemokine ligand 8,910).normal subjects[63].…”

mentioning

confidence: 99%

Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections

Quesada‐Gómez

Castillo

Bouillon

2020

The Journal of Steroid Biochemistry and Molecular Biology

138

170

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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1,25-Dihydroxyvitamin D3 induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: A pilot study

Cited by 30 publications

References 49 publications

Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti‐Inflammatory

Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti‐Inflammatory

Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections

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