1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress invitro antibody response to T cell-dependent antigen

Komoriya, Keiji; Nagata, Ikuo; Tsuchimoto, Masahiro; Kunisawa, Keiko; Takeshita, Toru; Naruchi, Tatsuyuki

doi:10.1016/s0006-291x(85)80007-3

Cited by 16 publications

(3 citation statements)

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“…1,24(R)-(OH)zD3, one of systemic analogues of vitamin D3, is known to bind to 1,25-(OH)2D 3 receptors in some tissues with almost the same binding affinity [29,30]. Furthermore, several pharmacological profiles of 1,24(R)-(OH)zD 3, such as intestinal calcium absorption [31] and immunoregulatory effects [32] are similar to those of 1,25-(OH)2D 3 . So, it is considered that 1,24(R)-(OH)2D 3 might affect on endotoxemia in the same mechanism of 1,25-(OH)zD 3.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of vitamin D3 analogues on endotoxin shock in mice

1991

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The effect of vitamin D3 analogues on endotoxin shock in mice was investigated. Male ICR mice were orally administered vitamin D3 analogues or vehicle, accompanied by an intraperitoneal injection of endotoxin (E. Coli lipopolysaccharide, LPS, 20 mg/kg). Endotoxin caused a decrease in survival rate in a time-dependent manner. Increases in plasma immunoreactive (i) eicosanoid and hepatic malondialdehyde (MDA) levels were also observed. Administration of 1 alpha-hydroxyvitamin D3 (1 alpha-OH-D3) improved the survival rate 24 to 48 h after endotoxin treatment. The effects were markedly observed at a dose of 20 ng/kg. In addition, 1 alpha-OH-D3 restored the plasma iTXB2 and hepatic MDA levels 8 h after endotoxin injection. However, it did not affect plasma iPGE2, i6-keto-PGF1 alpha and blood iLTB4 levels. At a dose of 20 ng/kg, both 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and 1,24(R)-dihydroxyvitamin D3 (1,24(R)-(OH)2D3) restored the survival rate, the plasma iTXB2 and hepatic MDA levels. These results suggest that vitamin D3 analogues may inhibit endotoxemia through regulation of the formation of TXA2 and free radicals.

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Section: Discussionmentioning

confidence: 99%

Protective effect of vitamin D3 analogues on endotoxin shock in mice

1991

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“…Rapid disappearance of scale and infiltration in psoriatic lesions, despite the persistence of slight erythema in our patients, suggests that ia,24(OH)2D3 may induce prompt differentiation of highly proliferative psoriatic epidermal cells into squamous cells. Furthermore, its inhibitory action of specific immunological activities (Komoriya et al, 1985) may have a beneficial effect on immunological processes taking place in psoriatic lesions. A preliminary study ruled out any measurable effect of vitamin D3 on polymorphonuclear leukocyte function (unpublished data).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of psoriasis with topical application of active vitamin D3 analogue, 1α, 24-dihydroxycholecalciferol

et al. 1986

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We treated 11 psoriatic patients with topical 1 alpha,24-dihydroxycholecalciferol, a new synthetic analogue of active vitamin D3. In 10 of 15 tests the lesions cleared completely within 1-4 weeks, although some relapses occurred shortly after cessation of treatment. There were no side-effects. We suggest that 1 alpha, 24(OH)2D3 merits further investigation as a potentially useful topical therapy for psoriasis.

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“…In accordance with its pleiotropic effects, VDRs have been documented in a wide variety of cells and tissues [Haussler, 1986;Reichel et al, 19891. With the discovery of VDRs in monocytes and activated T [Prowedini et al, 1983;Bhalla et al, 1983;Merke et al, 19841 and B cells [Prowedini et al, 19861, efforts have been focused on the effects of this steroid class on the immune system. In the human, 1,25 (OH)2 D3 inhibits lectin induced lymphocyte proliferation [Tsoukas et al, 1984;Rigby et al, 1984;Saggese et al, 19891, and production of IL-2 [Tsoukas et al, 1984;Rigby et al, 1987;Matsui et al, 1986;Saggese et al, 19891, interferon gamma [Reichel et al, 1987;Saggese et al, 1989;Matsui et al, 19861, granulocyte-macrophage colony stimulating factor [Tobler et al, 19881, and antibody [Komoriya et al, 1985;Prowedini et al, 1986;Iho et al, 1986;Lemire et al, 19841. In the mouse, 1,25 (OH)z D3 fails to inhibit lectininduced mitogenesis of splenic T cells but does impair antigen and alloantigen T cell stimulation [Bhalla et al, 19841 as well as thymocyte proliferation induced by interleukin 1 (IL-11, IL-2, andlor phytohemagglutinin exposure [Ravid et al, 1984;Koizumi et al, 1985;Muller et al, 19881.…”

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1,25‐Dihydroxyvitamin D₃ increases type 1 interleukin‐1 receptor expression in a murine T cell line

Erdmann

Tan

1993

J of Cellular Biochemistry

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The biologically active metabolite of vitamin D3, 1,25 (OH)2 D3, exerts important immunoregulatory effects in addition to being a central mediator of calcium/phosphate metabolism. Utilizing an interleukin 1 responsive murine T cell line and 125I-interleukin 1 alpha, we show that 1,25 (OH)2 D3 (5,50 nM) enhanced 125I-interleukin 1 alpha binding up to almost 2-fold over control. This 1,25 (OH)2 D3 effect occurred in a dose-dependent manner and was detectable after 24 h but not before 7 h of culture. Scatchard analysis of 125I-interleukin 1 alpha binding data demonstrated that 1,25 (OH)2 D3 enhanced interleukin 1 receptor number without a significant change in affinity. The biologically less potent metabolite of vitamin D3, 25 (OH) D3, also augmented 125I-interleukin 1 alpha binding but at steroid levels 2-3 log orders greater than 1,25 (OH)2 D3. This observation, combined with the presence of high-affinity 3H-1,25 (OH)2 D3 receptors (88 sites/cell, K = 0.45 nM) in cytosolic extracts, strongly suggests that the nuclear vitamin D receptor mediates this steroid's effect on interleukin 1 receptor expression. Based on the capacity of an anti-type 1 interleukin 1 receptor monoclonal antibody (35F5) to block 1,25 (OH)2 D3-enhanced 125I-interleukin 1 alpha binding, we conclude that this steroid augments type 1 interleukin 1 receptor expression. When combined with interleukin 1, a cytokine that also impacts MD10 interleukin 1 receptor expression, 1,25 (OH)2 D3 enhanced interleukin 1 receptor expression. Northern blots hybridized with a 32P-type 1 interleukin 1 receptor cDNA probe show that 1,25 (OH)2 D3 enhanced type 1 interleukin 1 receptor steady state mRNA levels. Functionally, 1,25 (OH)2 D3 pretreatment augmented the MD10 proliferative response to suboptimal levels of interleukin 1 (< 100 fM interleukin 1 alpha). These findings further support 1,25 (OH)2 D3's role as an immunoregulatory molecule and provides a possible mechanism by which this steroid could potentiate certain immune activities.

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1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress invitro antibody response to T cell-dependent antigen

Cited by 16 publications

References 10 publications

Protective effect of vitamin D3 analogues on endotoxin shock in mice

Protective effect of vitamin D3 analogues on endotoxin shock in mice

Successful treatment of psoriasis with topical application of active vitamin D3 analogue, 1α, 24-dihydroxycholecalciferol

1,25‐Dihydroxyvitamin D₃ increases type 1 interleukin‐1 receptor expression in a murine T cell line

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1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 suppress invitro antibody response to T cell-dependent antigen

Cited by 16 publications

References 10 publications

Protective effect of vitamin D3 analogues on endotoxin shock in mice

Protective effect of vitamin D3 analogues on endotoxin shock in mice

Successful treatment of psoriasis with topical application of active vitamin D3 analogue, 1α, 24-dihydroxycholecalciferol

1,25‐Dihydroxyvitamin D3 increases type 1 interleukin‐1 receptor expression in a murine T cell line

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1,25‐Dihydroxyvitamin D₃ increases type 1 interleukin‐1 receptor expression in a murine T cell line