1-(2-Hydroxyethyl)imidazolidine-2-thione

Abstract

1-(2-Hydroxyethyl)imidazolidine-2-thione (1) was obtained as a product from an in situ reaction between N-(2-hydroxyethyl)ethylenediamine, carbon disulfide, potassium hydroxide, and di(4-fluorobenzyl)tin dichloride. Compound 1 was characterized by IR, UV, 1H, 13C{1H}, and 2D (COSY, NOESY, HSQC, and HMBC) NMR spectroscopies. The cyclic molecular structure was confirmed by single crystal X-ray crystallography which showed the five-membered ring to be non-planar and the π-electron density to be localized over the CN2S chromophore. In the crystal, thioamide–N–H…O(hydroxy) and hydroxy–O–H…S(thione) hydrogen bonds lead to supramolecular layers in the bc-plane.

2-[Carbamothioyl(2-hydroxyethyl)amino]ethyl benzoate: crystal structure, Hirshfeld surface analysis and computational study

“…8, i.e. acyclic (II) (IYAYAJ; Griffiths et al, 2010) and cyclic imidazolidine-2-thione (III) (DOJSUT; Lee et al, 2018).…”