1,2-Dimyristoyl-sn-glycero-3-phosphocholine promotes the adhesion of nanoparticles to bio-membranes and transport in rat brain

Abstract

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) coated on the surface of superparamagnetic iron oxide nanoparticles (SPIONs) has advantages in neurotherapy and drug delivery.

In situ injectable NIR-responsive supramolecular hydrogels encapsulating ROS-triggered chain-breakage prodrug micelles and hydrophilic Fe3O4 nanoparticles for enhanced synergistic chemo-photothermal therapy

“…PEG/PEI@Fe 3 O 4 NPs were synthesized via a one-step method of thermal decomposition according to the literature. 64 PEI (0.6 g) and PEG1000 (30 g) were added to a three-neck flask, and the temperature was uniformly increased to 80 °C. After stirring for 10 min, Fe(acac) 3 (1.0 g) was added with stirring for 10 min to dissolve fully.…”

Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration

“…In another study, PVP-SPIONs were bio-conjugated with 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) [ 120 ]. Then, PVP-SPIONs and DMPC/PVP-SPIONs were co-incubated with rat adrenal pheochromocytoma (PC-12) cells to evaluate the effect of this phospholipid on the biodistribution of the SPIONs.…”

“…Then, PVP-SPIONs and DMPC/PVP-SPIONs were co-incubated with rat adrenal pheochromocytoma (PC-12) cells to evaluate the effect of this phospholipid on the biodistribution of the SPIONs. Further, PVP-SPIONs and DMPC/PVP-SPIONs were implanted into the substantia nigra of Sprague–Dawley (SD) rats by stereotaxic injection, and the brain tissues were explanted at two time points after injection, i.e., at 24 h and 7 days after injection [ 120 ]. The lipophilic nature of these NPs allowed their attachment to bio-membranes in the brain.…”

“…Also, a faster brain delivery of DMPC/PVP-SPIONs was reported compared to those without DMPC. Good biocompatibility and biodegradability properties resulted from the in vitro assays, with a related ability to activate neuron membrane channels [ 120 ].…”