1,2-Difunctionalizations of alkynes entailing concomitant C–C and C–N bond-forming carboamination reactions

Nanda, Santosh Kumar; Mallik, Rosy

doi:10.1039/d1ra06633a

Cited by 6 publications

(2 citation statements)

References 95 publications

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“…Previously, we have described various literature assessments on the transition metal and metal-free functionalization of alkynes involving C-C and C-N bond-forming reactions. [19][20][21] In this review, we aim to present different conceptual approaches on the transition metal-catalysed functionalization of alkynes involving C-and C-O bond formation. Further, we present detailed insights into the mechanism of different transformations.…”

Section: Subhra Sriharsa Beheramentioning

confidence: 99%

Transition metal catalysed cascade C–C and C–O bond forming events of alkynes

Barik,

Behera,

Nayak

et al. 2024

Org. Biomol. Chem.

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Section: Subhra Sriharsa Beheramentioning

confidence: 99%

Transition metal catalysed cascade C–C and C–O bond forming events of alkynes

Barik,

Behera,

Nayak

et al. 2024

Org. Biomol. Chem.

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“…The functionalization reactions of alkynes are always significant research topic in chemical research. [20][21][22][23][24][25] Combining the dearomatization of electron rich aromatic compounds with functionalization transformations of alkynes provides a completely novel avenue for dearomative vinylation of electron rich aromatic compounds.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal‐Catalyzed Dearomative Vinylation of Electron Rich Benzenes, Naphthalenes and Indoles with Alkynes

et al. 2023

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Dearomatization reactions are among the most efficient chemical processes, combining atom economy, stereospecificity and the ability to generate molecular complexity in a single step. Dearomative vinylation reactions provide a synthetic connection between readily available, simple aromatic starting materials and more unsaturated alkynes. The last decade has witnessed a steady increase in the development of transition metal-catalyzed dearomative vinylation methods of electron rich aromatic compounds with alkynes, providing new synthetic approaches to high-value building blocks and natural products. This review aims to serve as a comprehensive reference for work in transition metal-catalyzed dearomative vinylation reactions of electron rich aromatic compounds with alkynes.

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Intermolecular Dearomative 1,2‐Amination/Carbonylation via Nucleophilic Addition of Simple Amines to Arene π‐Bonds

Wang

et al. 2023

Chemistry A European J

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The incorporation of the privileged amino functionality is of paramount importance in organic synthesis. In contrast to the well‐developed amination methods for alkenes, the dearomative amination of arenes is largely underexplored due to the inherently inert reactivity of arene π‐bonds and selectivity challenges. Herein, we report an intermolecular dearomative aminofunctionalization via direct nucleophilic addition of simple amines to chromium‐bound arenes. This multicomponent 1,2‐amination/carbonylation reaction enables rapid access to complicated alicyclic compounds containing amino and amide functionalities from benzene derivatives under CO‐gas‐free conditions, which also represents the first application of nitrogen‐based nucleophiles in η6‐coordination‐induced arene dearomatizations.

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1,2-Difunctionalizations of alkynes entailing concomitant C–C and C–N bond-forming carboamination reactions

Abstract: The 1,2-difunctionalization of alkynes happening through concomitant C–C and C–N bond formation strategies have provide an unified access to diversely functionalized N-bearing heterocycles.

Cited by 6 publications

References 95 publications

Transition metal catalysed cascade C–C and C–O bond forming events of alkynes

Transition metal catalysed cascade C–C and C–O bond forming events of alkynes

Transition Metal‐Catalyzed Dearomative Vinylation of Electron Rich Benzenes, Naphthalenes and Indoles with Alkynes

Intermolecular Dearomative 1,2‐Amination/Carbonylation via Nucleophilic Addition of Simple Amines to Arene π‐Bonds

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