1,2-Bis(<i>N</i>′-benzoylthioureido)benzene

Thiam, Ibrahima Elhadji; Diop, Mouhamadou Birame; Gaye, Mohamed; Sall, Abdou Salam; Barry, Aliou Hamady

doi:10.1107/s1600536808008374

Cited by 23 publications

(25 citation statements)

References 2 publications

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“…In 2011, 1,2-Bis(N'-benzoylthioureidothioureido)-4-cholorobenzene was reported by Yamin research group [19]. The former compound is similar to 1,2-bis(N'-benzoylthioureido)benzene reported by Thiam and co-workers [20] during 2008 except for the presence of 4-chlorobenzene b ridge at 1,2 position that connected the two benzoyl thioureido group.…”

Section: Introductionsupporting

confidence: 55%

Characterization and Antimicrobial Studies of Five Substituted Bis-Thioureas

Kamalulazmy¹,

Mutalib²,

Nasir³

et al. 2016

MJAS

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Thioureas play an important role in medicinal chemistry and agricultures due to their biological activity such as antibacterial, antifungal, antiviral, herbicides, rodenticides, phenoloxidase enzymatic inhibitors, anti-HIV and anti-tumor agents. In this study, five substituted bis-thioureas have been synthesized. The isophataloyl chloride and 2,6-pyridinedicarbonyl dichloride were easily converted to bis-isothiocyanate compound via the reaction with ammonium thiocyanate by solid-liquid phase transfer catalysis of polyethylene glycol-400 (PEG-400). Bis-isothiocyanate compound was reacted with aniline derivatives to produce substituted bis-thioureas in good yield at room temperature. All the novel compounds were obtained as yellow solid after recrystallization using DMF/EtOH/H 2 O. Their c h e m i c a l structures were confirmed by Infrared spectrosopy (IR), Nuclear Magnetic Resonance (NMR) 1 H and 13 C and mass spectrometry. The five synthesized compounds were screened for antimicrobial activities using disc diffusion method for antimicrobial activity against Gram-positive bacteria (Bacillus Subtilis and Staphylococcus Aureus), Gram-negative bacteria (Escherichia Coli and Salmonella Typhi) and a mold (Aspergillus Niger). All tested compounds showed low antimicrobial activity since the diameter of inhibition zone (IZ) measure was less than positive control inhibition zone.

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Section: Introductionsupporting

confidence: 55%

Characterization and Antimicrobial Studies of Five Substituted Bis-Thioureas

Kamalulazmy¹,

Mutalib²,

Nasir³

et al. 2016

MJAS

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“…[216,[365][366][367][368] The same procedure can be applied for aromatic diamines. [224,[369][370][371][372] In general, these molecules belong to the C i = S 2 point-group symmetry, with a crystallographic center of inversion located in the middle of the (alkyl) bridge. Similar to the thiourea analogues, bifurcated hydrogen bonds (N−H···O and N−H···S) are observed in the crystals.…”

Section: Bis-di-thioureamentioning

confidence: 99%

A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

Saeed

Flörke

Erben

2013

Journal of Sulfur Chemistry

187

123

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This review provides an overview of the chemistry, structure and potential applications of 1-(acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R 1 C(O)N (1) HC(S)N (3) R 2 R 3 . In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra-and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono-and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure-activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007.

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“…Carbonyl vibration (C O) detected to 1666 cm −1 for BTB and 1667 cm −1 for FTB. There is a shift of these bands to shorter wavelengths than expected; this is attributed by several authors [4,16,25] to the formation of intramolecular hydrogen bonds (Fig. 1b).…”

Section: Synthesis and Characterization Of Bis-thioureasmentioning

confidence: 70%

“…The most deshielded signal (ı = 12.20 and 12.11 ppm for BTB and FTB, respectively) was assigned to N (3)H and N (4)H. This chemical shift is that high because these protons form hydrogen bonds [4,16,25]. This was demonstrated by a correlation analysis of ı NH in DMSO-d 6 vs. Hammett and by addition of europium (III) in CDC1 3 [26].…”

Section: Synthesis and Characterization Of Bis-thioureasmentioning

confidence: 99%